HitPredict

Interactor 1: LRP1 (Q07954)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Interactor 2: FBX2 (Q9UK22)
F-box only protein 2
Gene: FBXO2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001540 - amyloid-beta binding GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 4544 Hs			1 296
+	Hs
		1060920 LRP1_HUMAN (24-4544): 0: 3504: 100.00		FBX6_HUMAN (40-296): 2.42e-133: 381: 49.81
+	Hs
		1453582 LRP1B_HUMAN (2-294): 1.31e-12: 77.2: 15.99		FBX2_HUMAN (1-296): 5.15e-147: 416: 100.00
+	Hs
		1120556 NID2_HUMAN (1679-1844): 1.09e-11: 74.1: 24.86		FBX2_HUMAN (1-296): 5.15e-147: 416: 100.00
+	Hs
		1022665 LRP2_HUMAN (2-286): 2.25e-10: 69.9: 13.86		FBX2_HUMAN (1-296): 5.15e-147: 416: 100.00
+	Hs
		1366686 SORL_HUMAN (1080-1344): 6.87e-10: 68.3: 13.65		FBX2_HUMAN (1-296): 5.15e-147: 416: 100.00
+	Hs
		572700 NID1_HUMAN (3259-3502): 3.72e-09: 65.6: 13.18		FBX2_HUMAN (1-296): 5.15e-147: 416: 100.00
+	Hs
		1366674 SORL_HUMAN (1080-1344): 6.87e-10: 68.3: 13.65		FBX6_HUMAN (40-296): 2.42e-133: 381: 49.81
+	Hs
		376552 LDLR_HUMAN (4098-4307): 8.05e-10: 67.6: 13.72		FBX6_HUMAN (40-296): 2.42e-133: 381: 49.81