Protein: LDLR
Low-density lipoprotein receptor (LDL receptor)

Gene: LDLR
Organism: Homo sapiens
Interactions: 144
UniProt ID: P01130

Gene Ontology (top 5):
GO:0001523 - retinoid metabolic process
GO:0001540 - amyloid-beta binding
GO:0001618 - virus receptor activity
GO:0001920 - negative regulation of receptor recycling
GO:0002020 - protease binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

376527

PCSK9
Proprotein convertase subtilisin/kexin type 9

5

1

Small-scale

0.924

High

376483

AMRP
Alpha-2-macroglobulin receptor-associated protein

4

10

Small-scale

0.906

High

376516

DLK2
Protein delta homolog 2

2

7

High-throughput

0.811

High

376519

EGFL6
Epidermal growth factor-like protein 6

2

14

High-throughput

0.811

High

376458

APOH
Beta-2-glycoprotein 1

1

6

Small-scale

0.716

High

376531

MYLIP
E3 ubiquitin-protein ligase MYLIP

5

3

Small-scale

0.713

High

376528

NET5
Netrin-5

2

20

High-throughput

0.694

High

168360

NCTR3
Natural cytotoxicity triggering receptor 3

1

2

High-throughput

0.691

High

376464

CATG
Cathepsin G

1

14

High-throughput

0.691

High

376541

TMPSD
Transmembrane protease serine 13

1

11

High-throughput

0.691

High

376553

IGSF5
Immunoglobulin superfamily member 5

1

1

High-throughput

0.691

High

376568

ST14
Suppressor of tumorigenicity 14 protein

1

8

High-throughput

0.691

High

376456

APOE
Apolipoprotein E

3

7

Small-scale

0.671

High

376455

LDLR
Low-density lipoprotein receptor

1

11

Small-scale

0.647

High

376554

GINM1
Glycoprotein integral membrane protein 1

3

0

High-throughput

0.638

High

144072

WNT7A
Protein Wnt-7a

2

16

High-throughput

0.628

High

376489

FCGRN
IgG receptor FcRn large subunit p51

2

5

High-throughput

0.628

High

376518

TAFA3
Chemokine-like protein TAFA-3

2

8

High-throughput

0.628

High

376478

CMA1
Chymase

1

17

High-throughput

0.618

High

376547

KLK15
Kallikrein-15

1

13

High-throughput

0.618

High

376566

KLK5
Kallikrein-5

1

12

High-throughput

0.618

High

269822

IGSF3
Immunoglobulin superfamily member 3

1

2

High-throughput

0.618

High

366075

THRB
Prothrombin

1

11

High-throughput

0.618

High

366452

UROK
Urokinase-type plasminogen activator

1

12

High-throughput

0.618

High

376474

VGFR1
Vascular endothelial growth factor receptor 1

1

3

Small-scale

0.618

High

376486

EPHA5
Ephrin type-A receptor 5

1

6

High-throughput

0.618

High

376497

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

13

High-throughput

0.618

High

376501

LRP8
Low-density lipoprotein receptor-related protein 8

1

11

High-throughput

0.618

High

376533

NECT2
Nectin-2

1

3

High-throughput

0.618

High

376540

CADM1
Cell adhesion molecule 1

1

2

High-throughput

0.618

High

376462

APOB
Apolipoprotein B-100

2

3

Small-scale

0.611

High

376470

PRG2
Bone marrow proteoglycan

3

6

High-throughput

0.609

High

376526

ZFP41
Zinc finger protein 41 homolog

3

17

High-throughput

0.609

High

376556

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

3

3

High-throughput

0.609

High

376565

PRG3
Proteoglycan 3

3

6

High-throughput

0.604

High

376564

UST
Uronyl 2-sulfotransferase

2

0

High-throughput

0.602

High

376490

WNT3A
Protein Wnt-3a

2

16

High-throughput

0.601

High

286337

DAB1
Disabled homolog 1

2

20

Small-scale

0.594

High

376502

FAT1
Protocadherin Fat 1

1

0

High-throughput

0.586

High

376539

SEM3C
Semaphorin-3C

1

0

High-throughput

0.586

High

376467

BIP
Endoplasmic reticulum chaperone BiP

2

3

Small-scale

0.584

High

376498

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

376561

EGFL7
Epidermal growth factor-like protein 7

1

13

High-throughput

0.575

High

376511

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

2

High-throughput

0.574

High

376550

ZN408
Zinc finger protein 408

2

10

High-throughput

0.574

High

376560

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

2

High-throughput

0.574

High

376476

RAB5A
Ras-related protein Rab-5A

2

8

High-throughput

0.571

High

376503

SNX17
Sorting nexin-17

1

4

Small-scale

0.561

High

176778

ATS3
A disintegrin and metalloproteinase with thrombospondin motifs 3

1

4

High-throughput

0.553

High

376517

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.553

High

376479

MAP4
Microtubule-associated protein 4

1

2

High-throughput

0.541

High

165884

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.536

High

341268

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.536

High

376465

LEG1
Galectin-1

1

14

High-throughput

0.536

High

376481

CD1B
T-cell surface glycoprotein CD1b

1

6

High-throughput

0.536

High

376482

PDIA3
Protein disulfide-isomerase A3

1

6

Small-scale

0.536

High

376495

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

3

High-throughput

0.536

High

376512

FSTL4
Follistatin-related protein 4

1

8

High-throughput

0.536

High

376520

DJC10
DnaJ homolog subfamily C member 10

1

7

High-throughput

0.536

High

376522

NRSN1
Neurensin-1

1

1

High-throughput

0.536

High

376532

S39A7
Zinc transporter SLC39A7

1

4

High-throughput

0.536

High

376543

WN10A
Protein Wnt-10a

1

16

High-throughput

0.536

High

376545

CXL16
C-X-C motif chemokine 16

1

1

High-throughput

0.536

High

376559

P2RX2
P2X purinoceptor 2

1

1

High-throughput

0.536

High

376562

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

9

High-throughput

0.536

High

376567

LIPG
Endothelial lipase

1

6

High-throughput

0.536

High

105068

APRIO
Alternative prion protein

2

4

High-throughput

0.533

High

376524

SH2D3
SH2 domain-containing protein 3C

2

4

High-throughput

0.521

High

376513

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.513

High

376536

T106A
Transmembrane protein 106A

1

0

High-throughput

0.513

High

376538

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

0

High-throughput

0.513

High

376473

CD36
Platelet glycoprotein 4

1

1

Small-scale

0.501

High

376496

DAB2
Disabled homolog 2

1

20

Small-scale

0.501

High

376509

ARH
Low density lipoprotein receptor adapter protein 1

1

20

Small-scale

0.501

High

224459

PI15
Peptidase inhibitor 15

1

5

High-throughput

0.489

High

335353

CCN6
Cellular communication network factor 6

1

6

High-throughput

0.489

High

376471

EDN3
Endothelin-3

1

3

High-throughput

0.489

High

376484

TIMP3
Metalloproteinase inhibitor 3

1

4

High-throughput

0.489

High

376488

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

2

High-throughput

0.489

High

376491

DEF1
Neutrophil defensin 1

1

2

High-throughput

0.489

High

376507

DB136
Defensin beta 136

1

1

High-throughput

0.489

High

376508

FX4L6
Forkhead box protein D4-like 6

1

6

High-throughput

0.489

High

376514

LYZL1
Lysozyme-like protein 1

1

3

High-throughput

0.489

High

376515

IGFL3
Insulin growth factor-like family member 3

1

6

High-throughput

0.489

High

376523

TAFA2
Chemokine-like protein TAFA-2

1

8

High-throughput

0.489

High

376525

DB123
Beta-defensin 123

1

3

High-throughput

0.489

High

376548

GREM2
Gremlin-2

1

2

High-throughput

0.489

High

376460

PLF4
Platelet factor 4

1

0

Small-scale

0.480

High

163218

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

2

High-throughput

0.479

High

217685

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

288329

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

3

Small-scale

0.479

High

324323

SLIK5
SLIT and NTRK-like protein 5

1

5

High-throughput

0.479

High

362546

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

376461

VTNC
Vitronectin

1

3

High-throughput

0.479

High

376463

MMP2
72 kDa type IV collagenase

1

4

Small-scale

0.479

High

376469

PDIA4
Protein disulfide-isomerase A4

1

6

Small-scale

0.479

High

376472

ENPL
Endoplasmin

1

1

Small-scale

0.479

High

376475

CADH2
Cadherin-2

1

2

High-throughput

0.479

High

376480

CALX
Calnexin

1

7

Small-scale

0.479

High

376500

CUL3
Cullin-3

1

11

High-throughput

0.479

High

376505

MICB
MHC class I polypeptide-related sequence B

1

4

High-throughput

0.479

High

376506

MICA
MHC class I polypeptide-related sequence A

1

4

High-throughput

0.479

High

376510

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

3

High-throughput

0.479

High

376557

PDXL2
Podocalyxin-like protein 2

1

2

High-throughput

0.479

High

376558

CRIM1
Cysteine-rich motor neuron 1 protein

1

13

High-throughput

0.479

High

376563

S39AA
Zinc transporter ZIP10

1

4

High-throughput

0.479

High

376534

CBP
CREB-binding protein

1

2

Small-scale

0.471

High

220112

SGCE
Epsilon-sarcoglycan

1

0

High-throughput

0.458

High

244043

SUSD5
Sushi domain-containing protein 5

1

0

High-throughput

0.458

High

270121

EFC14
EF-hand calcium-binding domain-containing protein 14

1

0

High-throughput

0.458

High

337159

APOM
Apolipoprotein M

1

0

High-throughput

0.458

High

376457

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.458

High

376487

GAS1
Growth arrest-specific protein 1

1

0

High-throughput

0.458

High

376493

H4
Histone H4

1

0

High-throughput

0.458

High

376504

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

376521

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

376542

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

376551

NPDC1
Neural proliferation differentiation and control protein 1

1

0

High-throughput

0.458

High

376569

AP1M2
AP-1 complex subunit mu-2

1

0

Small-scale

0.458

High

349352

TSN15
Tetraspanin-15

1

3

High-throughput

0.445

High

376477

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

376492

TSN5
Tetraspanin-5

1

3

High-throughput

0.445

High

376529

SSMM1
Serine-rich single-pass membrane protein 1

1

1

High-throughput

0.445

High

376537

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.445

High

142041

CCN1
CCN family member 1

1

6

High-throughput

0.437

High

323070

TRI37
E3 ubiquitin-protein ligase TRIM37

1

7

High-throughput

0.437

High

342086

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.437

High

376485

CEBPD
CCAAT/enhancer-binding protein delta

1

1

Small-scale

0.437

High

376494

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

376535

FGF11
Fibroblast growth factor 11

1

2

High-throughput

0.437

High

376552

FBX6
F-box only protein 6

1

8

High-throughput

0.437

High

254713

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

167429

WNT9A
Protein Wnt-9a

1

16

High-throughput

0.407

High

376466

GOG8G
Golgin subfamily A member 8G

1

2

High-throughput

0.407

High

376468

ECP
Eosinophil cationic protein

1

1

High-throughput

0.407

High

376530

PATE1
Prostate and testis expressed protein 1

1

2

High-throughput

0.407

High

376546

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

295380

CBR3
Carbonyl reductase [NADPH] 3

1

0

High-throughput

0.279

Low

376499

MFAP5
Microfibrillar-associated protein 5

1

0

High-throughput

0.279

Low

376544

KTBL1
KATNB1-like protein 1

1

0

High-throughput

0.279

Low

376459

RET4
Retinol-binding protein 4

1

0

High-throughput

0.249

Low

376549

AAMDC
Mth938 domain-containing protein

1

0

High-throughput

0.249

Low

376555

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025