Protein: RIGI
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)

Gene: RIGI
Organism: Homo sapiens
Interactions: 112
UniProt ID: O95786

Gene Ontology (top 5):
GO:0002230 - positive regulation of defense response to virus by host
GO:0002735 - positive regulation of myeloid dendritic cell cytokine production
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0003690 - double-stranded DNA binding
GO:0003724 - RNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

321911

MAVS
Mitochondrial antiviral-signaling protein

52

15

Small-scale

0.996

High

321897

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

35

20

Small-scale

0.993

High

321861

RIGI
Antiviral innate immune response receptor RIG-I

10

17

Small-scale

0.974

High

321915

RN135
E3 ubiquitin-protein ligase RNF135

7

17

Small-scale

0.973

High

321868

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

18

Small-scale

0.899

High

321864

ISG15
Ubiquitin-like protein ISG15

3

17

Small-scale

0.839

High

321924

DHX58
ATP-dependent RNA helicase DHX58

3

18

Small-scale

0.827

High

269593

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

2

20

Small-scale

0.802

High

171470

UBD
Ubiquitin D

2

18

Small-scale

0.754

High

224740

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

13

Small-scale

0.724

High

321932

TRIM6
Tripartite motif-containing protein 6

1

7

Small-scale

0.724

High

321894

SQSTM
Sequestosome-1

5

11

Small-scale

0.702

High

321944

RAI14
Ankycorbin

1

10

High-throughput

0.691

High

157396

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

5

Small-scale

0.665

High

321914

STING
Stimulator of interferon genes protein

3

5

Small-scale

0.657

High

321899

IRF3
Interferon regulatory factor 3

3

7

Small-scale

0.650

High

321907

TRI65
E3 ubiquitin-protein ligase TRIM65

1

16

Small-scale

0.647

High

321948

TBK1
Serine/threonine-protein kinase TBK1

3

15

Small-scale

0.640

High

321927

WRIP1
ATPase WRNIP1

2

3

High-throughput

0.639

High

133808

DDX3X
ATP-dependent RNA helicase DDX3X

1

17

Small-scale

0.618

High

226167

PRKN
E3 ubiquitin-protein ligase parkin

1

20

Small-scale

0.618

High

321867

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

18

Small-scale

0.618

High

321872

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

12

Small-scale

0.618

High

321895

TRI14
Tripartite motif-containing protein 14

1

19

High-throughput

0.618

High

321909

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

321931

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

7

Small-scale

0.618

High

321935

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

20

Small-scale

0.618

High

321940

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

4

Small-scale

0.612

High

321926

RN125
E3 ubiquitin-protein ligase RNF125

2

20

Small-scale

0.611

High

49652

IRGM
Immunity-related GTPase family M protein

2

0

Small-scale

0.598

High

321892

G3BP1
Ras GTPase-activating protein-binding protein 1

2

15

Small-scale

0.584

High

321934

ATG5
Autophagy protein 5

1

1

Small-scale

0.569

High

321865

KPCB
Protein kinase C beta type

1

8

Small-scale

0.561

High

321871

KPCA
Protein kinase C alpha type

1

8

Small-scale

0.561

High

321906

TRI40
E3 ubiquitin ligase TRIM40

1

16

Small-scale

0.561

High

321916

CCD50
Coiled-coil domain-containing protein 50

1

1

Small-scale

0.561

High

321938

RN122
RING finger protein 122

1

5

Small-scale

0.561

High

321952

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

15

Small-scale

0.561

High

321955

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

14

Small-scale

0.561

High

321918

LRC25
Leucine-rich repeat-containing protein 25

2

0

Small-scale

0.559

High

321954

SNX5
Sorting nexin-5

1

2

Small-scale

0.552

High

321910

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

8

Small-scale

0.546

High

321891

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.536

High

321945

VAPA
Vesicle-associated membrane protein-associated protein A

1

3

High-throughput

0.536

High

321869

IRF1
Interferon regulatory factor 1

1

7

Small-scale

0.534

High

321896

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

10

Small-scale

0.515

High

321939

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

8

Small-scale

0.515

High

321943

NOP53
Ribosome biogenesis protein NOP53

1

1

Small-scale

0.515

High

321950

ASC
Apoptosis-associated speck-like protein containing a CARD

1

3

Small-scale

0.515

High

321863

KPCG
Protein kinase C gamma type

1

11

Small-scale

0.501

High

321878

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

3

Small-scale

0.501

High

321880

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

3

Small-scale

0.501

High

321881

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

4

Small-scale

0.501

High

321884

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

3

Small-scale

0.501

High

296685

ATG12
Ubiquitin-like protein ATG12

1

1

Small-scale

0.500

High

49997

MEX3A
RNA-binding protein MEX3A

1

20

Small-scale

0.479

High

135327

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

10

High-throughput

0.479

High

165749

N4BP3
NEDD4-binding protein 3

1

5

Small-scale

0.479

High

231939

KDM1A
Lysine-specific histone demethylase 1A

1

6

Small-scale

0.479

High

321866

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

20

Small-scale

0.479

High

321870

SRC
Proto-oncogene tyrosine-protein kinase Src

1

8

Small-scale

0.479

High

321873

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

9

Small-scale

0.479

High

321874

CBL
E3 ubiquitin-protein ligase CBL

1

8

Small-scale

0.479

High

321876

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

321877

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

Small-scale

0.479

High

321879

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

13

Small-scale

0.479

High

321882

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.479

High

321883

1433E
14-3-3 protein epsilon

1

4

Small-scale

0.479

High

321885

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

10

Small-scale

0.479

High

321886

TIAR
Nucleolysin TIAR

1

15

Small-scale

0.479

High

321887

TF65
Transcription factor p65

1

9

Small-scale

0.479

High

321888

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

5

Small-scale

0.479

High

321889

TRI32
E3 ubiquitin-protein ligase TRIM32

1

13

Small-scale

0.479

High

321890

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

15

Small-scale

0.479

High

321893

BIRC2
Baculoviral IAP repeat-containing protein 2

1

14

Small-scale

0.479

High

321898

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

7

Small-scale

0.479

High

321900

CASP8
Caspase-8

1

9

Small-scale

0.479

High

321901

PCBP1
Poly(rC)-binding protein 1

1

20

Small-scale

0.479

High

321902

PCBP2
Poly(rC)-binding protein 2

1

20

Small-scale

0.479

High

321903

ELAV1
ELAV-like protein 1

1

11

Small-scale

0.479

High

321905

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

13

Small-scale

0.479

High

321912

ZN598
E3 ubiquitin-protein ligase ZNF598

1

6

Small-scale

0.479

High

321913

NLRC5
Protein NLRC5

1

7

Small-scale

0.479

High

321917

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

12

Small-scale

0.479

High

321919

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

9

Small-scale

0.479

High

321920

IRF7
Interferon regulatory factor 7

1

7

Small-scale

0.479

High

321921

FBXW7
F-box/WD repeat-containing protein 7

1

20

Small-scale

0.479

High

321922

RNF34
E3 ubiquitin-protein ligase RNF34

1

12

Small-scale

0.479

High

321923

LRC59
Leucine-rich repeat-containing protein 59

1

5

Small-scale

0.479

High

321925

RNF31
E3 ubiquitin-protein ligase RNF31

1

19

Small-scale

0.479

High

321928

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

14

Small-scale

0.479

High

321929

RNF5
E3 ubiquitin-protein ligase RNF5

1

15

Small-scale

0.479

High

321930

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

16

Small-scale

0.479

High

321933

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

19

Small-scale

0.479

High

321936

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

321937

AZI2
5-azacytidine-induced protein 2

1

1

Small-scale

0.479

High

321941

ZCHC3
Zinc finger CCHC domain-containing protein 3

1

9

Small-scale

0.479

High

321946

HDAC6
Histone deacetylase 6

1

20

Small-scale

0.479

High

321949

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

14

Small-scale

0.479

High

321951

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.479

High

321953

ARI1
E3 ubiquitin-protein ligase ARIH1

1

18

Small-scale

0.479

High

321956

NEMO
NF-kappa-B essential modulator

1

7

Small-scale

0.479

High

209299

TSN6
Tetraspanin-6

1

6

Small-scale

0.470

High

321862

MBP
Myelin basic protein

1

0

Small-scale

0.458

High

321942

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.458

High

306959

RTN3
Reticulon-3

1

4

Small-scale

0.437

High

321908

WDR82
WD repeat-containing protein 82

1

20

Small-scale

0.437

High

321947

KLOT
Klotho

1

1

Small-scale

0.437

High

203082

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

0

Small-scale

0.261

Low

321875

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

0

Small-scale

0.249

Low

321904

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024