HitPredict

Interactor 1: HERC3 (Q15034)
Probable E3 ubiquitin-protein ligase HERC3 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 3) (HECT-type E3 ubiquitin transferase HERC3)
Gene: HERC3

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	26476452, 18535780
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0031410 - cytoplasmic vesicle
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1050 Hs			1 589
+	Hs
		1065054 HERC3_HUMAN (1-1050): 0: 1145: 100.00		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		924302 HERC3_HUMAN (1-1050): 0: 1145: 100.00		RL40_HUMAN (37-126): 1.88e-34: 128: 30.77
+	Hs
		983269 UBE3A_HUMAN (460-1049): 1.23e-180: 550: 28.43		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		125787 WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		1336119 SMUF1_HUMAN (596-1047): 4.57e-174: 529: 25.91		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		983264 UBE3A_HUMAN (460-1049): 1.23e-180: 550: 28.43		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		1336106 SMUF1_HUMAN (596-1047): 4.57e-174: 529: 25.91		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		125739 WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06		UBQL4_HUMAN (28-589): 1.35e-135: 409: 57.64
+	Hs
		983150 UBE3A_HUMAN (460-1049): 1.23e-180: 550: 28.43		DDI2_HUMAN (47-318): 2.03e-49: 178: 13.52
+	Hs
		1355829 HERC5_HUMAN (1-206): 5.55e-50: 194: 31.82		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		125225 WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06		BAG6_HUMAN (25-536): 2.14e-33: 138: 14.66
+	Hs
		924414 SMUF2_HUMAN (557-1047): 1.53e-170: 519: 23.66		RL40_HUMAN (37-126): 1.88e-34: 128: 30.77
+	Sp
		145418 PUB3_SCHPO (682-1048): 2.98e-162: 499: 31.48		RL402_SCHPO (37-126): 3.84e-31: 119: 29.67
+	Hs
		125347 WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68
+	Hs
		924156 WWP1_HUMAN (605-1048): 6.26e-173: 532: 24.09		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68
+	Hs
		1218013 HERC6_HUMAN (1-208): 8.56e-38: 155: 24.34		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Dm
		89880 D5SHR3_DROME (692-1049): 3.17e-152: 460: 29.92		RL40_DROME (37-126): 7.82e-34: 126: 29.67