HitPredict

Interactor 1: PDCD1 (Q15116)
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
Gene: PDCD1

Interactor 2: PD1L1 (Q9NZQ7)
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
Gene: CD274

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.976

Property	Details
Experiments	31802034, 21982860, 36657039, 26602187, 12893276, 11015443, 18841514, 23417675, 20587542
Identification Methods	pull down, molecular sieving, x-ray crystallography, surface plasmon resonance, solid phase assay, nuclear magnetic resonance, protein array, isothermal titration calorimetry
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C2-set_2~V-set, V-set~V-set
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 288 Hs			1 290
+	Mm
		970112 PDCD1_MOUSE (1-288): 1.49e-179: 497: 59.31		PD1L1_MOUSE (1-290): 2.5e-57: 187: 69.42
+	Hs
		1067939 PDCD1_HUMAN (1-288): 0: 506: 100.00		PD1L2_HUMAN (19-259): 1.4e-52: 174: 38.43
+	Mm
		970114 PDCD1_MOUSE (1-288): 1.49e-179: 497: 59.31		PD1L2_MOUSE (13-263): 1.95e-49: 165: 33.20
+	Hs
		706897 PDCD1_HUMAN (1-288): 0: 506: 100.00		CD80_HUMAN (28-259): 6.01e-30: 116: 21.07