HitPredict

Interactor 1: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Interactor 2: DCAF8 (Q5TAQ9)
DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)
Gene: DCAF8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.984

Property	Details
Experiments	16949367, 28514442, 31155351, 31257023, 32235678, 32703400, 33288900, 33961781, 16964240, 19295130, 35271311, 37689310, 24500646, 19966799, 31391242
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1140 Hs			1 597
+	Mm
		1112284 DDB1_MOUSE (1-1140): 0: 1422: 99.65		DCAF8_MOUSE (1-597): 4.88e-127: 387: 95.49
+	Hs
		473600 DDB1_HUMAN (1-1140): 0: 1424: 100.00		DC8L2_HUMAN (1-597): 8.22e-110: 344: 65.56
+	Hs
		1082337 DDB1_HUMAN (1-1140): 0: 1424: 100.00		DCAF5_HUMAN (153-542): 6e-79: 269: 22.72
+	Mm
		1112258 DDB1_MOUSE (1-1140): 0: 1422: 99.65		DCAF5_MOUSE (153-542): 1.05e-78: 269: 22.72
+	Hs
		1082374 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL1R_HUMAN (323-595): 1.19e-49: 181: 12.63
+	Hs
		1082281 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDTC1_HUMAN (405-597): 4.23e-46: 174: 30.30
+	Mm
		1112265 DDB1_MOUSE (1-1140): 0: 1422: 99.65		WDTC1_MOUSE (405-597): 3.07e-46: 175: 29.80
+	Hs
		1082327 DDB1_HUMAN (1-1140): 0: 1424: 100.00		SNR40_HUMAN (83-358): 2.66e-47: 171: 14.69
+	Hs
		903254 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5_HUMAN (278-585): 2.83e-45: 165: 12.18
+	Mm
		1112305 DDB1_MOUSE (1-1140): 0: 1422: 99.65		DCAF6_MOUSE (415-576): 2.85e-41: 162: 36.36
+	Hs
		1082217 DDB1_HUMAN (1-1140): 0: 1424: 100.00		DCAF6_HUMAN (415-576): 1.36e-40: 159: 36.36
+	Hs
		245605 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL1X_HUMAN (365-588): 1.06e-37: 149: 9.87
+	Zm
		37968 A0A1D6ME60_MAIZE (3-1140): 0: 1244: 52.57		B4FRU9_MAIZE (149-590): 3.92e-89: 285: 34.24
+	Hs
		1082263 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5B_HUMAN (466-589): 5.53e-21: 96.2: 15.20
+	Mm
		1112266 DDB1_MOUSE (1-1140): 0: 1422: 99.65		WDR82_MOUSE (329-546): 8.72e-13: 71.4: 10.90
+	Hs
		1016284 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL3_HUMAN (76-182): 1.35e-09: 63: 9.35
+	At
		1340744 DDB1A_ARATH (2-1140): 0: 1255: 52.09		Q9M1E5_ARATH (96-423): 6.06e-18: 88.9: 10.35
+	At
		221833 DDB1B_ARATH (3-1140): 0: 1248: 50.92		Q9M1E5_ARATH (96-423): 6.06e-18: 88.9: 10.35
+	Hs
		1073094 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		FBXW7_HUMAN (312-594): 7.67e-52: 191: 12.28
+	Hs
		1073168 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		NLE1_HUMAN (86-182): 4.74e-11: 67.2: 8.25