Protein: FXL19
F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19)

Gene: FXL19, FBXL19
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q6PCT2

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006338 - chromatin remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992218

SKP1
S-phase kinase-associated protein 1

7

20

Small-scale

0.962

High

960459

PSME3
Proteasome activator complex subunit 3

7

2

High-throughput

0.750

High

1243774

DEN2D
DENN domain-containing protein 2D

3

0

High-throughput

0.638

High

1112554

CUL1
Cullin-1

1

20

Small-scale

0.618

High

1113430

CUL3
Cullin-3

1

20

High-throughput

0.618

High

222115

NCK2
Cytoplasmic protein NCK2

2

5

High-throughput

0.606

High

250273

VINEX
Vinexin

2

1

High-throughput

0.606

High

1243754

ABI1
Abl interactor 1

2

3

High-throughput

0.606

High

1243783

ABI2
Abl interactor 2

2

2

High-throughput

0.606

High

48977

MED19
Mediator of RNA polymerase II transcription subunit 19

2

0

High-throughput

0.602

High

1108357

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.602

High

1243782

MED29
Mediator of RNA polymerase II transcription subunit 29

2

0

High-throughput

0.602

High

1243779

RPRM
Protein reprimo

2

0

High-throughput

0.580

High

572031

TRI27
Zinc finger protein RFP

1

2

High-throughput

0.541

High

1120911

TRI29
Tripartite motif-containing protein 29

1

4

High-throughput

0.541

High

168709

CSKP
Peripheral plasma membrane protein CASK

1

1

High-throughput

0.536

High

239588

MED14
Mediator of RNA polymerase II transcription subunit 14

1

7

High-throughput

0.536

High

445007

S10A9
Protein S100-A9

1

3

High-throughput

0.536

High

479834

GSTP1
Glutathione S-transferase P

1

1

High-throughput

0.536

High

656159

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

High-throughput

0.536

High

666849

CCNC
Cyclin-C

1

5

High-throughput

0.536

High

724590

S10A7
Protein S100-A7

1

3

High-throughput

0.536

High

881548

CDK8
Cyclin-dependent kinase 8

1

7

High-throughput

0.536

High

964645

DCAF7
DDB1- and CUL4-associated factor 7

1

5

High-throughput

0.536

High

1023020

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

1

2

High-throughput

0.536

High

1103236

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.536

High

1151260

MED1
Mediator of RNA polymerase II transcription subunit 1

1

4

High-throughput

0.536

High

1206220

PREP
Presequence protease, mitochondrial

1

2

High-throughput

0.536

High

1243755

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

3

High-throughput

0.536

High

1243758

FAN
Protein FAN

1

3

High-throughput

0.536

High

1243761

MED12
Mediator of RNA polymerase II transcription subunit 12

1

4

High-throughput

0.536

High

1243765

MED15
Mediator of RNA polymerase II transcription subunit 15

1

6

High-throughput

0.536

High

1243768

PLCD4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

1

3

High-throughput

0.536

High

1243771

CDK19
Cyclin-dependent kinase 19

1

7

High-throughput

0.536

High

1243777

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

1

High-throughput

0.536

High

1243784

ITSN2
Intersectin-2

1

2

High-throughput

0.536

High

1243786

MED13
Mediator of RNA polymerase II transcription subunit 13

1

1

High-throughput

0.536

High

216181

MTG8R
Protein CBFA2T2

1

0

High-throughput

0.518

High

282391

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

High-throughput

0.513

High

287798

MED6
Mediator of RNA polymerase II transcription subunit 6

1

0

High-throughput

0.513

High

332313

ATE1
Arginyl-tRNA--protein transferase 1

1

0

High-throughput

0.513

High

391302

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

611905

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

770214

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.513

High

955946

RAB8A
Ras-related protein Rab-8A

1

0

High-throughput

0.513

High

973474

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.513

High

1215651

GRTP1
Growth hormone-regulated TBC protein 1

1

0

High-throughput

0.513

High

1241385

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.513

High

1243763

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.513

High

1243764

MED30
Mediator of RNA polymerase II transcription subunit 30

1

0

High-throughput

0.513

High

1243766

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

0

High-throughput

0.513

High

1243767

SORT
Sortilin

1

0

High-throughput

0.513

High

1243769

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.513

High

1243770

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

High-throughput

0.513

High

1243772

PIP30
PSME3-interacting protein

1

0

High-throughput

0.513

High

1243773

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.513

High

1243776

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

1243778

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

1243781

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1243785

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.513

High

1243788

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.513

High

1243789

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

1243790

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.513

High

1243791

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.513

High

1243793

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

1243759

CBP
CREB-binding protein

1

7

Small-scale

0.501

High

1100614

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.493

High

1243760

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.493

High

190398

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.489

High

296715

TUSC2
Tumor suppressor candidate 2

1

1

High-throughput

0.489

High

837361

ECI1
Enoyl-CoA delta isomerase 1, mitochondrial

1

1

High-throughput

0.489

High

1208922

DCA10
DDB1- and CUL4-associated factor 10

1

6

High-throughput

0.489

High

1228384

SE1L3
Protein sel-1 homolog 3

1

1

High-throughput

0.489

High

1243752

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

1

High-throughput

0.489

High

1243762

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

4

High-throughput

0.489

High

272692

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

6

Small-scale

0.479

High

897866

CDK9
Cyclin-dependent kinase 9

1

7

Small-scale

0.479

High

934757

TERA
Transitional endoplasmic reticulum ATPase

1

4

Small-scale

0.479

High

953514

RAC3
Ras-related C3 botulinum toxin substrate 3

1

1

Small-scale

0.479

High

954167

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

1061594

FOXM1
Forkhead box protein M1

1

4

Small-scale

0.479

High

1087811

NFIA
Nuclear factor 1 A-type

1

5

High-throughput

0.479

High

1206327

WDR44
WD repeat-containing protein 44

1

7

Small-scale

0.479

High

1217869

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

7

Small-scale

0.479

High

1243753

STRAA
STE20-related kinase adapter protein alpha

1

9

Small-scale

0.479

High

1243787

XPO7
Exportin-7

1

5

High-throughput

0.479

High

1243792

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.458

High

76545

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

11

High-throughput

0.437

High

551743

COBA1

1

1

Small-scale

0.437

High

1206390

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

1243751

DG2L6
Diacylglycerol O-acyltransferase 2-like protein 6

2

0

High-throughput

0.316

High

1243757

TM239
Transmembrane protein 239

2

0

High-throughput

0.316

High

167707

LIN7A
Protein lin-7 homolog A

1

0

High-throughput

0.279

Low

572365

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

0

High-throughput

0.279

Low

962968

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.279

Low

1053374

CTSL2
CTD small phosphatase-like protein 2

1

0

High-throughput

0.279

Low

1181203

ANO4
Anoctamin-4

1

0

High-throughput

0.279

Low

1243756

VANG1
Vang-like protein 1

1

0

High-throughput

0.279

Low

1243775

NOL11
Nucleolar protein 11

1

0

High-throughput

0.279

Low

1243780

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025