HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: KSR2 (Q6VAB6)
Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1)
Gene: KSR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	32707033, 25036637
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 378 Hs			1 950
+	Rn
		88626 CDC37_RAT (1-377): 8.29e-168: 475: 95.24		D3ZHL1_RAT (19-949): 0: 585: 46.52
+	Hs
		1072507 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA7_HUMAN (93-941): 0: 575: 14.63
+	Hs
		872655 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA4_HUMAN (79-949): 0: 571: 14.24
+	Hs
		665401 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA3_HUMAN (88-939): 0: 567: 14.56
+	Hs
		665610 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHB2_HUMAN (79-950): 9.48e-179: 548: 13.45
+	Hs
		872447 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA5_HUMAN (70-939): 1.18e-174: 537: 14.83
+	Hs
		665253 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA2_HUMAN (112-950): 2.48e-173: 531: 15.49
+	Hs
		665480 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA8_HUMAN (102-946): 1.04e-167: 517: 13.54
+	Hs
		1083031 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA6_HUMAN (68-939): 8.89e-166: 513: 14.56
+	Hs
		872537 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHB4_HUMAN (59-939): 9.29e-161: 499: 14.30
+	Hs
		600580 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA1_HUMAN (125-950): 2.7e-159: 495: 14.54
+	Hs
		981879 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		RON_HUMAN (78-935): 2.46e-145: 468: 16.94
+	Hs
		441514 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		MET_HUMAN (88-934): 2.77e-134: 438: 14.43
+	Hs
		542886 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		BRAF_HUMAN (325-942): 1.44e-134: 423: 22.19
+	Mm
		655953 CDC37_MOUSE (1-377): 2.28e-166: 471: 94.97		BRAF_MOUSE (284-942): 7.45e-137: 429: 22.01
+	Hs
		374293 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		RAF1_HUMAN (304-945): 1.34e-129: 407: 22.49
+	Hs
		1082922 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		Q96II5_HUMAN (321-949): 2.47e-128: 402: 22.27
+	Hs
		488732 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ARAF_HUMAN (321-949): 4.2e-127: 399: 22.12
+	Gg
		223346 CDC37_CHICK (1-345): 1.08e-141: 409: 85.76		BRAF_CHICK (324-942): 1.32e-131: 416: 22.62
+	Dm
		507713 CDC37_DROME (1-351): 1.28e-126: 371: 52.54		KRAF1_DROME (411-942): 6.95e-111: 360: 26.57