Protein: DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)

Gene: DPH2
Organism: Homo sapiens
Interactions: 31
UniProt ID: Q9BQC3

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0017183 - protein histidyl modification to diphthamide
GO:0046872 - metal ion binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0090560 - 2-(3-amino-3-carboxypropyl)histidine synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1410487

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

3

1

High-throughput

0.667

High

1410481

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

6

High-throughput

0.665

High

537799

HSP7C
Heat shock cognate 71 kDa protein

3

1

High-throughput

0.657

High

1391098

DPH3
Diphthamide biosynthesis protein 3

2

2

High-throughput

0.628

High

1220489

F219B
Protein FAM219B

3

1

High-throughput

0.609

High

1207963

COL12
Collectin-12

2

0

High-throughput

0.602

High

961099

MGN
Protein mago nashi homolog

2

0

High-throughput

0.580

High

1060805

ACK1
Activated CDC42 kinase 1

2

0

High-throughput

0.580

High

1410482

NEK6
Serine/threonine-protein kinase Nek6

2

0

High-throughput

0.580

High

303179

RGS20
Regulator of G-protein signaling 20

2

3

High-throughput

0.558

High

347285

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

1410483

M1IP1
Mid1-interacting protein 1

1

1

High-throughput

0.536

High

1158654

IL17
Interleukin-17A

1

2

High-throughput

0.523

High

1241998

DJC24
DnaJ homolog subfamily C member 24

1

3

High-throughput

0.515

High

1408130

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.513

High

1132168

ICAM4
Intercellular adhesion molecule 4

1

1

High-throughput

0.489

High

1150471

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

1

High-throughput

0.489

High

1216356

ZC21B
Zinc finger C2HC domain-containing protein 1B

1

1

High-throughput

0.489

High

1410485

STIM2
Stromal interaction molecule 2

1

1

High-throughput

0.489

High

1410486

IL17B
Interleukin-17B

1

2

High-throughput

0.489

High

1403561

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.479

High

1410480

ST4A1
Sulfotransferase 4A1

1

1

High-throughput

0.479

High

1175919

Q24JT5
CRYGA protein

1

1

High-throughput

0.470

High

347896

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

549471

CRGA
Gamma-crystallin A

1

1

High-throughput

0.439

High

75576

B3KSW4
Regulator of G protein signaling 20

1

3

High-throughput

0.407

High

211406

RFOX2
RNA binding protein fox-1 homolog 2

3

0

High-throughput

0.347

High

1410484

HPBP1
Hsp70-binding protein 1

2

0

High-throughput

0.328

High

334459

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

1309152

MISP
Mitotic interactor and substrate of PLK1

2

0

High-throughput

0.316

High

1255269

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025