Protein: DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)

Gene: DPH1
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q9BZG8

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0017183 - protein histidyl modification to diphthamide
GO:0030054 - cell junction
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

675146

TNR6
Tumor necrosis factor receptor superfamily member 6

3

1

High-throughput

0.667

High

1419901

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

3

1

High-throughput

0.667

High

1410481

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

1

6

High-throughput

0.665

High

635380

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

3

1

High-throughput

0.662

High

537856

HSP7C
Heat shock cognate 71 kDa protein

3

1

High-throughput

0.657

High

1419900

CARD8
Caspase recruitment domain-containing protein 8

3

0

High-throughput

0.638

High

239198

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.602

High

279484

TULP3
Tubby-related protein 3

2

0

High-throughput

0.602

High

553761

MYCL
Protein L-Myc

2

0

High-throughput

0.602

High

1110558

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

0

High-throughput

0.602

High

1388948

ARSG
Arylsulfatase G

2

0

High-throughput

0.602

High

622677

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

2

High-throughput

0.574

High

303188

RGS20
Regulator of G-protein signaling 20

2

3

High-throughput

0.558

High

1086308

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.549

High

347303

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

1419893

M1IP1
Mid1-interacting protein 1

1

1

High-throughput

0.536

High

549676

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

1066018

VAC14
Protein VAC14 homolog

1

0

High-throughput

0.513

High

508571

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.501

High

1132170

ICAM4
Intercellular adhesion molecule 4

1

1

High-throughput

0.489

High

1150478

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

1

High-throughput

0.489

High

1216359

ZC21B
Zinc finger C2HC domain-containing protein 1B

1

1

High-throughput

0.489

High

1220491

F219B
Protein FAM219B

1

1

High-throughput

0.489

High

1419897

STIM2
Stromal interaction molecule 2

1

1

High-throughput

0.489

High

1419898

IL17B
Interleukin-17B

1

2

High-throughput

0.489

High

1419899

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

2

High-throughput

0.489

High

535503

BIP
Endoplasmic reticulum chaperone BiP

1

3

Small-scale

0.481

High

186799

P73
Tumor protein p73

1

3

High-throughput

0.479

High

209332

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

1

High-throughput

0.479

High

414563

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

1242000

DJC24
DnaJ homolog subfamily C member 24

1

3

High-throughput

0.479

High

1403568

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.479

High

1411006

ST4A1
Sulfotransferase 4A1

1

1

High-throughput

0.479

High

1419892

P63
Tumor protein 63

1

3

High-throughput

0.479

High

1419902

RBM8A
RNA-binding protein 8A

1

0

Small-scale

0.460

High

242839

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

520351

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

589617

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696430

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

769102

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

1419895

DCA13
DDB1- and CUL4-associated factor 13

1

0

Small-scale

0.458

High

75581

B3KSW4
Regulator of G protein signaling 20

1

3

High-throughput

0.407

High

212487

SPIT2
Kunitz-type protease inhibitor 2

3

0

High-throughput

0.347

High

914476

EFNB2
Ephrin-B2

3

0

High-throughput

0.347

High

1419903

KPTN
KICSTOR complex protein kaptin

3

0

High-throughput

0.347

High

1153505

RAB30
Ras-related protein Rab-30

2

0

High-throughput

0.328

High

1372443

P2RX5
P2X purinoceptor 5

2

0

High-throughput

0.328

High

1419894

PLS4
Phospholipid scramblase 4

2

0

High-throughput

0.318

High

1419896

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

2

0

High-throughput

0.318

High

71245

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

190479

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

829926

PMEL
Melanocyte protein PMEL

1

0

High-throughput

0.279

Low

294290

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

941545

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.249

Low

1289148

OSTA
Organic solute transporter subunit alpha

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025