Protein: DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)

Gene: DPH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 44
UniProt ID: P40487

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0017183 - protein histidyl modification to diphthamide
GO:0046872 - metal ion binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0090560 - 2-(3-amino-3-carboxypropyl)histidine synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

737145

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

8

6

Small-scale

0.973

High

734118

EF2
Elongation factor 2

3

1

High-throughput

0.765

High

825369

DPH3
Diphthamide biosynthesis protein 3

8

2

Small-scale

0.745

High

579526

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.588

High

524172

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.552

High

545140

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.552

High

818940

SSB2
Ribosome-associated molecular chaperone SSB2

2

6

High-throughput

0.552

High

646604

TRX1
Thioredoxin-1

1

2

High-throughput

0.515

High

488618

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

0

High-throughput

0.513

High

366813

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.493

High

417115

VDAC1
Non-selective voltage-gated ion channel 1

1

0

High-throughput

0.493

High

452669

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.493

High

518311

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.493

High

745277

ELM1
Serine/threonine-protein kinase ELM1

1

0

High-throughput

0.493

High

809330

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

825361

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.493

High

470140

SPS1
Sporulation-specific protein 1

1

0

High-throughput

0.480

High

811539

MNN1
Alpha-1,3-mannosyltransferase MNN1

1

1

High-throughput

0.470

High

825360

DPH4
Diphthamide biosynthesis protein 4

1

1

High-throughput

0.457

High

510550

HSP77
Import motor subunit, mitochondrial

1

7

High-throughput

0.445

High

526874

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

597163

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.445

High

671648

SCJ1
DnaJ-related protein SCJ1

1

2

High-throughput

0.445

High

741718

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

816242

HSP7E
Heat shock protein SSC3, mitochondrial

1

7

High-throughput

0.445

High

825362

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.445

High

825365

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

11

High-throughput

0.445

High

809263

MET30
F-box protein MET30

1

0

High-throughput

0.438

High

825364

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

0

High-throughput

0.438

High

707299

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

394628

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

590645

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

727087

HS104
Heat shock protein 104

1

0

High-throughput

0.426

High

735011

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.426

High

823262

JEM1
DnaJ-like chaperone JEM1

1

3

High-throughput

0.407

High

825359

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.407

High

810826

TCPG
T-complex protein 1 subunit gamma

2

0

High-throughput

0.298

High

825366

CORO
Coronin-like protein

1

0

High-throughput

0.269

Low

825368

ZEO1
Protein ZEO1

1

0

High-throughput

0.269

Low

825363

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

459105

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.232

Low

597479

EF3A
Elongation factor 3A

1

0

High-throughput

0.232

Low

626764

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low

825367

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025