Protein: DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)

Gene: DPH2
Organism: Saccharomyces cerevisiae S288C
Interactions: 29
UniProt ID: P32461

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0017183 - protein histidyl modification to diphthamide
GO:0046872 - metal ion binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0090560 - 2-(3-amino-3-carboxypropyl)histidine synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

737145

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

8

6

Small-scale

0.973

High

734040

EF2
Elongation factor 2

3

1

High-throughput

0.769

High

737151

DPH3
Diphthamide biosynthesis protein 3

5

2

Small-scale

0.706

High

737142

HSP7E
Heat shock protein SSC3, mitochondrial

2

7

High-throughput

0.588

High

510302

HSP77
Import motor subunit, mitochondrial

2

7

High-throughput

0.571

High

646591

TRX1
Thioredoxin-1

1

2

High-throughput

0.515

High

652858

TRX2
Thioredoxin-2

1

2

High-throughput

0.515

High

575909

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.493

High

441068

KAPA
cAMP-dependent protein kinase type 1

1

0

High-throughput

0.480

High

737141

MNN1
Alpha-1,3-mannosyltransferase MNN1

1

1

High-throughput

0.470

High

737139

KAE1
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.458

High

737147

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.458

High

737149

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.458

High

481533

HSP73
Heat shock protein SSA3

1

6

High-throughput

0.445

High

523356

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

526171

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

544159

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.445

High

579036

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.445

High

671594

SCJ1
DnaJ-related protein SCJ1

1

2

High-throughput

0.445

High

675811

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

737137

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

737138

MDJ1
DnaJ homolog 1, mitochondrial

1

1

High-throughput

0.445

High

737143

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

706494

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

737140

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.407

High

737144

JEM1
DnaJ-like chaperone JEM1

1

3

High-throughput

0.407

High

737146

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.407

High

737150

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.261

Low

737148

JAC1
J-type co-chaperone JAC1, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025