HitPredict

Interactor 1: KCC4 (Q16566)
Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR)
Gene: CAMK4

Interactor 2: GIT1 (Q9Y2X7)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Gene: GIT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.80	0.779

Property	Details
Experiments	28514442, 33961781, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 473 Hs			1 761
+	Hs
		1357913 KCC2A_HUMAN (40-448): 1.11e-144: 424: 33.65		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Rn
		506783 KCC2A_RAT (40-448): 1.05e-144: 424: 33.65		GIT1_RAT (1-761): 4.42e-170: 510: 95.71
+	Hs
		1050113 KCC4_HUMAN (1-473): 2.74e-164: 474: 100.00		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Mm
		1112593 KCC2D_MOUSE (40-448): 2.01e-144: 424: 35.10		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Mm
		515228 KCC2A_MOUSE (40-448): 1.05e-144: 424: 33.65		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Mm
		1112637 KCC2G_MOUSE (40-448): 6.95e-144: 423: 34.42		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Rn
		506765 KCC2A_RAT (40-448): 1.05e-144: 424: 33.65		AGAP2_RAT (2-223): 2.7e-48: 186: 29.28
+	Mm
		659450 KCC2B_MOUSE (40-448): 3.08e-143: 422: 31.60		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Hs
		166938 KCC4_HUMAN (1-473): 2.74e-164: 474: 100.00		ANR28_HUMAN (52-250): 1.89e-18: 92.5: 11.06
+	Hs
		166632 DCLK1_HUMAN (10-368): 5.47e-69: 235: 37.27		AGAP1_HUMAN (2-223): 4.13e-57: 211: 32.89