HitPredict

Interactor 1: NFIL3 (Q21361)
Transcription factor atf-2 (cAMP-dependent transcription factor atf-2)
Gene: atf-2

Interactor 2: CES2 (Q94126)
Transcription factor ces-2 (Cell death specification protein 2)
Gene: ces-2

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.894

Property	Details
Experiments	23661758, 23791784, 16310763, 14704431
Identification Methods	fluorescent resonance energy transfer, two hybrid, affinity chromatography technology, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	bZIP_2~bZIP_2
Common GO terms	GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046982 - protein heterodimerization activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 401 Ce			1 211
+	Ce
		183675 NFIL3_CAEEL (1-401): 0: 520: 100.00		O16213_CAEEL (104-186): 4.98e-23: 94.5: 48.19
+	Ce
		1094195 NFIL3_CAEEL (1-401): 0: 520: 100.00		NFIL3_CAEEL (100-162): 1.28e-13: 70.6: 39.06
+	Ce
		1094203 NFIL3_CAEEL (1-401): 0: 520: 100.00		Q9NAE4_CAEEL (108-177): 7.2e-14: 68.7: 41.43
+	Ce
		1094198 NFIL3_CAEEL (1-401): 0: 520: 100.00		CEBP2_CAEEL (101-180): 1.19e-11: 60.6: 32.50
+	Ce
		183677 O16213_CAEEL (50-154): 1.12e-33: 127: 32.46		CES2_CAEEL (1-211): 4.83e-61: 191: 100.00
+	Dm
		1137469 Q5U8V5_DROME (25-111): 5.29e-36: 134: 24.14		Q5U8V5_DROME (47-181): 9e-29: 110: 35.29
+	Dm
		1249546 Q8SZT1_DROME (25-111): 5.81e-33: 132: 24.14		Q8SZT1_DROME (47-181): 8.24e-27: 108: 35.29
+	Mm
		1337520 TEF_MOUSE (25-106): 5.61e-30: 119: 23.17		TEF_MOUSE (48-181): 2.05e-27: 107: 33.58
+	Hs
		1082497 NFIL3_HUMAN (4-127): 1.91e-28: 118: 33.33		HLF_HUMAN (19-181): 1.16e-26: 105: 33.13
+	Ce
		183671 O16213_CAEEL (50-154): 1.12e-33: 127: 32.46		O16213_CAEEL (104-186): 4.98e-23: 94.5: 48.19
+	Dm
		55012 A1ZAC2_DROME (10-112): 1.25e-32: 123: 25.71		A1ZAC2_DROME (104-181): 5.4e-25: 98.3: 50.00
+	Hs
		569653 TEF_HUMAN (25-106): 1.76e-30: 120: 23.17		CEBPB_HUMAN (83-188): 4.58e-24: 99.2: 23.59
+	Mm
		1141849 TEF_MOUSE (25-106): 5.61e-30: 119: 23.17		DBP_MOUSE (33-182): 2.69e-24: 99.6: 31.74
+	Hs
		569789 NFIL3_HUMAN (4-127): 1.91e-28: 118: 33.33		CEBPB_HUMAN (83-188): 4.58e-24: 99.2: 23.59
+	Mm
		1141847 HLF_MOUSE (25-107): 2.66e-29: 117: 24.10		DBP_MOUSE (33-182): 2.69e-24: 99.6: 31.74
+	Hs
		1085124 NFIL3_HUMAN (4-127): 1.91e-28: 118: 33.33		NFIL3_HUMAN (77-206): 2.39e-20: 90: 32.31
+	Hs
		831376 NFIL3_HUMAN (4-127): 1.91e-28: 118: 33.33		CEBPA_HUMAN (78-187): 2.38e-20: 89.2: 21.82
+	Ce
		183678 O16213_CAEEL (50-154): 1.12e-33: 127: 32.46		Q9NAE4_CAEEL (108-177): 7.2e-14: 68.7: 41.43
+	Ce
		183676 O16213_CAEEL (50-154): 1.12e-33: 127: 32.46		CEBP2_CAEEL (101-180): 1.19e-11: 60.6: 32.50