Protein: ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein)

Gene: ERCC3
Organism: Homo sapiens
Interactions: 150
UniProt ID: P19447

Gene Ontology (top 5):
GO:0000112 - nucleotide-excision repair factor 3 complex
GO:0000439 - transcription factor TFIIH core complex
GO:0000717 - nucleotide-excision repair, DNA duplex unwinding
GO:0001666 - response to hypoxia
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584559

TF2H1
General transcription factor IIH subunit 1

15

2

Small-scale

0.980

High

584594

TF2H2
General transcription factor IIH subunit 2

13

2

Small-scale

0.980

High

584626

TF2H4
General transcription factor IIH subunit 4

9

3

Small-scale

0.971

High

584571

MAT1
CDK-activating kinase assembly factor MAT1

7

1

Small-scale

0.963

High

584616

TF2H5
General transcription factor IIH subunit 5

8

0

Small-scale

0.925

High

584609

T2H2L
General transcription factor IIH subunit 2-like protein

3

2

High-throughput

0.861

High

584544

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

8

Small-scale

0.827

High

584568

CDK7
Cyclin-dependent kinase 7

17

9

Small-scale

0.763

High

574122

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

9

2

Small-scale

0.754

High

584595

TF2H3
General transcription factor IIH subunit 3

10

1

Small-scale

0.754

High

584570

CCNH
Cyclin-H

10

4

Small-scale

0.749

High

506513

BCR
Breakpoint cluster region protein

5

2

Small-scale

0.724

High

584550

ERCC5
DNA excision repair protein ERCC-5

4

1

Small-scale

0.697

High

386070

P53
Cellular tumor antigen p53

4

5

Small-scale

0.696

High

584585

XPC
DNA repair protein complementing XP-C cells

3

1

Small-scale

0.660

High

345896

MYC
Myc proto-oncogene protein

3

12

Small-scale

0.656

High

131377

IMA4
Importin subunit alpha-4

3

1

High-throughput

0.654

High

536725

TRI27
Zinc finger protein RFP

3

1

High-throughput

0.650

High

584572

ZN143
Zinc finger protein 143

2

1

High-throughput

0.628

High

584589

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

2

4

High-throughput

0.628

High

584628

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

13

High-throughput

0.628

High

584582

XIAP
E3 ubiquitin-protein ligase XIAP

2

8

High-throughput

0.628

High

584586

ERCC6
DNA excision repair protein ERCC-6

1

17

Small-scale

0.618

High

584593

SNW1
SNW domain-containing protein 1

2

3

High-throughput

0.606

High

584596

TRI14
Tripartite motif-containing protein 14

2

5

High-throughput

0.606

High

584649

MAGD1
Melanoma-associated antigen D1

2

8

High-throughput

0.606

High

584552

T2EA
General transcription factor IIE subunit 1

2

2

Small-scale

0.602

High

584599

LRC41
Leucine-rich repeat-containing protein 41

2

0

High-throughput

0.602

High

584579

PRS8
26S proteasome regulatory subunit 8

1

1

Small-scale

0.597

High

299317

UBXN7
UBX domain-containing protein 7

2

2

Small-scale

0.584

High

584612

ATL4
ADAMTS-like protein 4

2

0

High-throughput

0.580

High

584634

GO45
Golgin-45

2

0

High-throughput

0.580

High

584637

ROP1A
Ropporin-1A

2

0

High-throughput

0.580

High

487119

ANDR
Androgen receptor

1

20

Small-scale

0.578

High

584633

LZTS2
Leucine zipper putative tumor suppressor 2

2

9

High-throughput

0.574

High

368965

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

584580

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.569

High

584605

UVSSA
UV-stimulated scaffold protein A

2

0

Small-scale

0.559

High

584620

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

4

High-throughput

0.541

High

125842

CDC7
Cell division cycle 7-related protein kinase

1

14

High-throughput

0.536

High

243290

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.536

High

396680

S10A8
Protein S100-A8

1

10

High-throughput

0.536

High

416348

S10A9
Protein S100-A9

1

11

High-throughput

0.536

High

542179

PLAK
Junction plakoglobin

1

7

High-throughput

0.536

High

542995

GLNA
Glutamine synthetase

1

1

High-throughput

0.536

High

583390

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

7

Small-scale

0.536

High

584538

FILA
Filaggrin

1

13

High-throughput

0.536

High

584545

ZA2G
Zinc-alpha-2-glycoprotein

1

1

High-throughput

0.536

High

584547

S100P
Protein S100-P

1

11

High-throughput

0.536

High

584554

SPB3
Serpin B3

1

6

High-throughput

0.536

High

584557

S10A7
Protein S100-A7

1

11

High-throughput

0.536

High

584558

CASPE
Caspase-14

1

5

High-throughput

0.536

High

584561

CETN2
Centrin-2

1

1

High-throughput

0.536

High

584564

KI67
Proliferation marker protein Ki-67

1

7

High-throughput

0.536

High

584565

LEG7
Galectin-7

1

4

High-throughput

0.536

High

584581

NGAL
Neutrophil gelatinase-associated lipocalin

1

3

High-throughput

0.536

High

584639

PRD11
PR domain-containing protein 11

1

4

High-throughput

0.536

High

584569

FXR1
RNA-binding protein FXR1

1

7

High-throughput

0.515

High

396195

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

546813

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

584541

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.513

High

584638

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

584592

SQSTM
Sequestosome-1

1

7

Small-scale

0.506

High

584540

TBG1
Tubulin gamma-1 chain

1

2

Small-scale

0.501

High

584543

CCNC
Cyclin-C

1

4

Small-scale

0.501

High

584553

T2EB
Transcription initiation factor IIE subunit beta

1

1

Small-scale

0.501

High

584567

CDK8
Cyclin-dependent kinase 8

1

7

Small-scale

0.501

High

584577

CDC42
Cell division control protein 42 homolog

1

12

Small-scale

0.501

High

584584

E2F1
Transcription factor E2F1

1

5

Small-scale

0.501

High

584563

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.493

High

245788

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

428554

INVO
Involucrin

1

2

High-throughput

0.489

High

453949

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.489

High

533959

ANXA8
Annexin A8

1

2

High-throughput

0.489

High

584539

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.489

High

584548

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.489

High

584551

S10A2
Protein S100-A2

1

11

High-throughput

0.489

High

584556

CD6
T-cell differentiation antigen CD6

1

4

High-throughput

0.489

High

584562

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

2

High-throughput

0.489

High

584566

SPB4
Serpin B4

1

6

High-throughput

0.489

High

584615

FBX50
F-box only protein 50

1

5

High-throughput

0.489

High

584618

S1A7A
Protein S100-A7A

1

11

High-throughput

0.489

High

584627

EVPL
Envoplakin

1

3

High-throughput

0.489

High

584643

CRNN
Cornulin

1

11

High-throughput

0.489

High

226488

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

233209

NUPR1
Nuclear protein 1

1

6

High-throughput

0.479

High

243913

BRD4
Bromodomain-containing protein 4

1

14

High-throughput

0.479

High

373659

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

500990

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.479

High

584542

CCND1
G1/S-specific cyclin-D1

1

1

Small-scale

0.479

High

584546

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

584549

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

584555

PML
Protein PML

1

10

High-throughput

0.479

High

584573

RD23B
UV excision repair protein RAD23 homolog B

1

4

Small-scale

0.479

High

584574

TERA
Transitional endoplasmic reticulum ATPase

1

3

Small-scale

0.479

High

584575

ANM2
Protein arginine N-methyltransferase 2

1

6

High-throughput

0.479

High

584576

MLF1
Myeloid leukemia factor 1

1

1

High-throughput

0.479

High

584583

VIGLN
Vigilin

1

14

High-throughput

0.479

High

584590

TP53B
TP53-binding protein 1

1

3

High-throughput

0.479

High

584591

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

7

High-throughput

0.479

High

584597

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

584598

BRD3
Bromodomain-containing protein 3

1

17

High-throughput

0.479

High

584600

PCBP1
Poly(rC)-binding protein 1

1

15

High-throughput

0.479

High

584601

TAF7
Transcription initiation factor TFIID subunit 7

1

1

Small-scale

0.479

High

584602

MLF2
Myeloid leukemia factor 2

1

1

High-throughput

0.479

High

584603

SMAD2
Mothers against decapentaplegic homolog 2

1

14

High-throughput

0.479

High

584606

BRDT
Bromodomain testis-specific protein

1

20

High-throughput

0.479

High

584613

MCAF1
Activating transcription factor 7-interacting protein 1

1

6

Small-scale

0.479

High

584619

SIR6
NAD-dependent protein deacylase sirtuin-6

1

8

High-throughput

0.479

High

584629

ZBT10
Zinc finger and BTB domain-containing protein 10

1

3

Small-scale

0.479

High

584640

ANLN
Anillin

1

5

High-throughput

0.479

High

584641

CDK12
Cyclin-dependent kinase 12

1

7

High-throughput

0.479

High

584644

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

584647

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

High-throughput

0.479

High

584648

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

4

High-throughput

0.479

High

584587

GOGA2
Golgin subfamily A member 2

1

2

High-throughput

0.464

High

73114

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

0

High-throughput

0.458

High

584560

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.458

High

584578

CSN2
COP9 signalosome complex subunit 2

1

0

Small-scale

0.458

High

584632

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

Small-scale

0.458

High

584636

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

584642

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

72276

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

2

High-throughput

0.437

High

322171

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

High-throughput

0.437

High

360614

SPTA1
Spectrin alpha chain, erythrocytic 1

1

3

Small-scale

0.437

High

584614

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

584625

GCN1
Stalled ribosome sensor GCN1

1

12

High-throughput

0.437

High

584635

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.437

High

584646

HECD1
E3 ubiquitin-protein ligase HECTD1

1

20

High-throughput

0.437

High

66375

A2ML1
Alpha-2-macroglobulin-like protein 1

1

2

High-throughput

0.407

High

584588

FGL1
Fibrinogen-like protein 1

3

0

High-throughput

0.347

High

584650

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

2

0

High-throughput

0.328

High

584622

CEP76
Centrosomal protein of 76 kDa

2

0

High-throughput

0.316

High

584621

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.299

High

152999

IMPA2
Inositol monophosphatase 2

1

0

High-throughput

0.279

Low

259827

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.279

Low

572109

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.279

Low

584537

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.279

Low

584604

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.279

Low

584608

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.279

Low

584611

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

584617

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

584623

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

584624

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

584631

GSDMA
Gasdermin-A

1

0

High-throughput

0.279

Low

584645

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.279

Low

500928

MCF2
Proto-oncogene DBL

1

0

Small-scale

0.261

Low

584610

MSD2
Myb/SANT-like DNA-binding domain-containing protein 2

1

0

High-throughput

0.251

Low

584607

EFHC2
EF-hand domain-containing family member C2

1

0

High-throughput

0.238

Low

584630

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024