Protein: UBP53
Ubiquitin carboxyl-terminal hydrolase 53 (EC 3.4.19.12) (Ubiquitin-specific peptidase 53)

Gene: UBP53, USP53
Organism: Homo sapiens
Interactions: 138
UniProt ID: Q70EK8

Gene Ontology (top 5):
GO:0001508 - action potential
GO:0005911 - cell-cell junction
GO:0005923 - bicellular tight junction
GO:0007605 - sensory perception of sound
GO:0010996 - response to auditory stimulus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1258066

NECT2
Nectin-2

1

0

High-throughput

0.663

High

855661

CRK
Adapter molecule crk

4

2

High-throughput

0.642

High

1258065

DDB2
DNA damage-binding protein 2

1

1

Small-scale

0.637

High

508179

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.579

High

855895

CRKL
Crk-like protein

2

2

High-throughput

0.553

High

140974

NOP56
Nucleolar protein 56

1

1

Small-scale

0.553

High

1258064

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

1

Small-scale

0.553

High

987729

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.541

High

882742

EFTU
Elongation factor Tu, mitochondrial

1

0

Small-scale

0.517

High

1258058

RPTOR
Regulatory-associated protein of mTOR

1

0

Small-scale

0.517

High

1258061

COP1
E3 ubiquitin-protein ligase COP1

1

0

High-throughput

0.517

High

1090741

TRAF2
TNF receptor-associated factor 2

1

3

High-throughput

0.494

High

718140

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

1

High-throughput

0.489

High

1258068

RAD50
DNA repair protein RAD50

1

1

High-throughput

0.489

High

764852

CTNB1
Catenin beta-1

1

1

Small-scale

0.479

High

945809

EPIPL
Epiplakin

1

2

Small-scale

0.479

High

1258087

ZO2
Tight junction protein 2

1

1

High-throughput

0.479

High

1258094

PKP3
Plakophilin-3

1

2

Small-scale

0.479

High

437234

K2C8
Keratin, type II cytoskeletal 8

1

0

Small-scale

0.458

High

1258063

PDC6I
Programmed cell death 6-interacting protein

1

0

Small-scale

0.458

High

286384

DAB1
Disabled homolog 1

1

4

High-throughput

0.439

High

144282

ACACB
Acetyl-CoA carboxylase 2

1

4

Small-scale

0.437

High

174772

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

1

Small-scale

0.437

High

193118

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

1

Small-scale

0.437

High

1258070

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

3

Small-scale

0.437

High

425816

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

4

Small-scale

0.437

High

436914

K1C18
Keratin, type I cytoskeletal 18

1

1

Small-scale

0.437

High

485799

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

Small-scale

0.437

High

547158

PYC
Pyruvate carboxylase, mitochondrial

1

4

Small-scale

0.437

High

610735

TCPA
T-complex protein 1 subunit alpha

1

1

Small-scale

0.437

High

730708

1433S
14-3-3 protein sigma

1

9

High-throughput

0.437

High

755742

MCM4
DNA replication licensing factor MCM4

1

1

Small-scale

0.437

High

756245

MCM7
DNA replication licensing factor MCM7

1

1

Small-scale

0.437

High

775561

NU214
Nuclear pore complex protein Nup214

1

1

Small-scale

0.437

High

790061

ZEB1
Zinc finger E-box-binding homeobox 1

1

1

Small-scale

0.437

High

915985

NUP98
Nuclear pore complex protein Nup98-Nup96

1

1

Small-scale

0.437

High

921698

COPB
Coatomer subunit beta

1

1

Small-scale

0.437

High

966515

1433G
14-3-3 protein gamma

1

9

High-throughput

0.437

High

1047599

NOTC2
Neurogenic locus notch homolog protein 2

1

1

Small-scale

0.437

High

1049468

1433F
14-3-3 protein eta

1

9

High-throughput

0.437

High

1094202

ACACA
Acetyl-CoA carboxylase 1

1

4

Small-scale

0.437

High

1125138

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

Small-scale

0.437

High

1143173

PLEC
Plectin

1

2

Small-scale

0.437

High

1258051

DDX46
Probable ATP-dependent RNA helicase DDX46

1

2

Small-scale

0.437

High

1258052

K2C1B
Keratin, type II cytoskeletal 1b

1

2

High-throughput

0.437

High

1258053

DDX42
ATP-dependent RNA helicase DDX42

1

2

Small-scale

0.437

High

1258057

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

1

Small-scale

0.437

High

1258060

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

3

Small-scale

0.437

High

1258062

BICD2
Protein bicaudal D homolog 2

1

3

High-throughput

0.437

High

1258067

SYN2
Synapsin-2

1

1

Small-scale

0.437

High

1258069

BICD1
Protein bicaudal D homolog 1

1

3

High-throughput

0.437

High

1258072

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

Small-scale

0.437

High

1258073

TCHP
Trichoplein keratin filament-binding protein

1

1

Small-scale

0.437

High

1258074

PCGF6
Polycomb group RING finger protein 6

1

1

Small-scale

0.437

High

1258077

DDX24
ATP-dependent RNA helicase DDX24

1

3

Small-scale

0.437

High

1258082

DDX18
ATP-dependent RNA helicase DDX18

1

1

Small-scale

0.437

High

1258084

SLTM
SAFB-like transcription modulator

1

1

Small-scale

0.437

High

1258089

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

1

Small-scale

0.437

High

1258091

NINL
Ninein-like protein

1

4

High-throughput

0.437

High

1258092

ZN281
Zinc finger protein 281

1

1

Small-scale

0.437

High

1070438

Q0IIN1
Keratin 77

1

3

High-throughput

0.407

High

1208546

SMAG2
Protein Smaug homolog 2

2

0

High-throughput

0.316

High

1023564

CYC
Cytochrome c

1

0

Small-scale

0.292

High

870962

IREB2
Iron-responsive element-binding protein 2

1

0

High-throughput

0.282

High

370320

CYTA
Cystatin-A

1

0

High-throughput

0.279

Low

399989

CATA
Catalase

1

0

High-throughput

0.279

Low

423670

ARGI1
Arginase-1

1

0

High-throughput

0.279

Low

552997

PIP
Prolactin-inducible protein

1

0

High-throughput

0.279

Low

671814

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.279

Low

729578

CASPE
Caspase-14

1

0

High-throughput

0.279

Low

905428

HCFC1
Host cell factor 1

1

0

High-throughput

0.279

Low

954843

PSA6
Proteasome subunit alpha type-6

1

0

High-throughput

0.279

Low

960153

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.279

Low

1036755

DSG1
Desmoglein-1

1

0

High-throughput

0.279

Low

1062250

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.279

Low

1118226

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.279

Low

1125354

FLNC
Filamin-C

1

0

High-throughput

0.279

Low

1258079

YAE1
Protein YAE1 homolog

1

0

High-throughput

0.279

Low

1258086

CPNE7
Copine-7

1

0

High-throughput

0.279

Low

96704

E9PAV9
G patch domain-containing protein 4

1

0

Small-scale

0.249

Low

158838

AP3D1
AP-3 complex subunit delta-1

1

0

Small-scale

0.249

Low

175715

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

Small-scale

0.249

Low

274173

ANR17
Ankyrin repeat domain-containing protein 17

1

0

Small-scale

0.249

Low

336978

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.249

Low

343181

RAB3D
Ras-related protein Rab-3D

1

0

Small-scale

0.249

Low

362052

AATM
Aspartate aminotransferase, mitochondrial

1

0

Small-scale

0.249

Low

374704

RASH
GTPase HRas

1

0

High-throughput

0.249

Low

460574

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

0

Small-scale

0.249

Low

485222

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

Small-scale

0.249

Low

539550

PYGB
Glycogen phosphorylase, brain form

1

0

Small-scale

0.249

Low

547632

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

Small-scale

0.249

Low

559397

XRCC5
X-ray repair cross-complementing protein 5

1

0

Small-scale

0.249

Low

569115

T2FB
General transcription factor IIF subunit 2

1

0

Small-scale

0.249

Low

598120

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

0

Small-scale

0.249

Low

624083

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

Small-scale

0.249

Low

643903

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.249

Low

664981

ERD21
ER lumen protein-retaining receptor 1

1

0

Small-scale

0.249

Low

766649

PHB1
Prohibitin 1

1

0

Small-scale

0.249

Low

770010

RFC1
Replication factor C subunit 1

1

0

Small-scale

0.249

Low

854129

KI67
Proliferation marker protein Ki-67

1

0

Small-scale

0.249

Low

859330

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.249

Low

881218

FAS
Fatty acid synthase

1

0

High-throughput

0.249

Low

913346

MSH6
DNA mismatch repair protein Msh6

1

0

Small-scale

0.249

Low

932895

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

Small-scale

0.249

Low

969637

RS15A
Small ribosomal subunit protein uS8

1

0

Small-scale

0.249

Low

979022

RS6
Small ribosomal subunit protein eS6

1

0

Small-scale

0.249

Low

981869

RL23
Large ribosomal subunit protein uL14

1

0

Small-scale

0.249

Low

1004354

NOP14
Nucleolar protein 14

1

0

Small-scale

0.249

Low

1024392

S25A3
Solute carrier family 25 member 3

1

0

Small-scale

0.249

Low

1032186

EXOSX
Exosome complex component 10

1

0

Small-scale

0.249

Low

1050695

DYN1
Dynamin-1

1

0

Small-scale

0.249

Low

1105980

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

Small-scale

0.249

Low

1117579

NOG2
Nucleolar GTP-binding protein 2

1

0

Small-scale

0.249

Low

1123948

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

Small-scale

0.249

Low

1124357

ELOA1
Elongin-A

1

0

Small-scale

0.249

Low

1129329

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

0

Small-scale

0.249

Low

1141720

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low

1155484

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

Small-scale

0.249

Low

1208772

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

Small-scale

0.249

Low

1210462

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

Small-scale

0.249

Low

1220936

FBX31
F-box only protein 31

1

0

Small-scale

0.249

Low

1243112

ALKB5
RNA demethylase ALKBH5

1

0

Small-scale

0.249

Low

1258054

INLR1
Interferon lambda receptor 1

1

0

Small-scale

0.249

Low

1258055

CREG2
Protein CREG2

1

0

Small-scale

0.249

Low

1258056

SUGP2
SURP and G-patch domain-containing protein 2

1

0

Small-scale

0.249

Low

1258059

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

Small-scale

0.249

Low

1258071

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

Small-scale

0.249

Low

1258075

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.249

Low

1258076

GTPB4
GTP-binding protein 4

1

0

Small-scale

0.249

Low

1258078

SYF1
Pre-mRNA-splicing factor SYF1

1

0

Small-scale

0.249

Low

1258080

HELLS
Lymphoid-specific helicase

1

0

Small-scale

0.249

Low

1258081

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

0

Small-scale

0.249

Low

1258083

RBM28
RNA-binding protein 28

1

0

Small-scale

0.249

Low

1258085

TMOD2
Tropomodulin-2

1

0

Small-scale

0.249

Low

1258088

BAZ1B
Tyrosine-protein kinase BAZ1B

1

0

Small-scale

0.249

Low

1258090

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

Small-scale

0.249

Low

1258093

NOC2L
Nucleolar complex protein 2 homolog

1

0

Small-scale

0.249

Low

66997

AXA2L
Putative annexin A2-like protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025