Protein: PYC
Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)

Gene: PYC, PC
Organism: Homo sapiens
Interactions: 189
UniProt ID: P11498

Gene Ontology (top 5):
GO:0004736 - pyruvate carboxylase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

547083

PYC
Pyruvate carboxylase, mitochondrial

2

16

Small-scale

0.812

High

547196

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

1

High-throughput

0.667

High

547092

3BHS2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

2

2

High-throughput

0.628

High

547226

STRAP
Serine-threonine kinase receptor-associated protein

2

13

High-throughput

0.628

High

425764

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

15

High-throughput

0.618

High

425873

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

19

High-throughput

0.618

High

547136

ACACA
Acetyl-CoA carboxylase 1

1

17

High-throughput

0.618

High

547193

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

16

High-throughput

0.618

High

547206

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

18

High-throughput

0.618

High

547205

ANTR1
Anthrax toxin receptor 1

2

1

High-throughput

0.611

High

349650

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.602

High

369011

ASSY
Argininosuccinate synthase

2

0

High-throughput

0.602

High

240599

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

413083

P53
Cellular tumor antigen p53

2

5

Small-scale

0.584

High

547104

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

547108

MAOX
NADP-dependent malic enzyme

1

2

Small-scale

0.565

High

547085

TSHR
Thyrotropin receptor

2

2

High-throughput

0.558

High

219912

XRCC3
DNA repair protein XRCC3

1

3

High-throughput

0.536

High

410560

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

7

High-throughput

0.536

High

488147

IFIT1
Antiviral innate immune response effector IFIT1

1

4

High-throughput

0.536

High

547093

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.536

High

547115

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.536

High

547117

YBEY
Endoribonuclease YbeY

1

2

High-throughput

0.536

High

547130

SHC2
SHC-transforming protein 2

1

6

High-throughput

0.536

High

547146

EPHA7
Ephrin type-A receptor 7

1

3

High-throughput

0.536

High

547155

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

1

High-throughput

0.536

High

547169

PAF1
RNA polymerase II-associated factor 1 homolog

1

4

High-throughput

0.536

High

547190

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

2

High-throughput

0.536

High

547197

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.536

High

547224

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

289301

FCN3
Ficolin-3

1

0

High-throughput

0.513

High

547106

PTN9
Tyrosine-protein phosphatase non-receptor type 9

1

0

High-throughput

0.513

High

547126

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.513

High

547134

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

547135

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

0

High-throughput

0.513

High

547150

LYRM7
Complex III assembly factor LYRM7

1

0

High-throughput

0.513

High

547173

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.513

High

547211

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

547219

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

547086

AATC
Aspartate aminotransferase, cytoplasmic

1

1

Small-scale

0.501

High

547103

MDHM
Malate dehydrogenase, mitochondrial

1

1

Small-scale

0.501

High

547183

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

547140

SLAF1
Signaling lymphocytic activation molecule

1

6

High-throughput

0.489

High

547162

IGFN1
Immunoglobulin-like and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.489

High

547189

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

547202

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

1

High-throughput

0.489

High

547102

MDHC
Malate dehydrogenase, cytoplasmic

1

2

Small-scale

0.484

High

547131

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.484

High

125185

LEG9
Galectin-9

1

6

High-throughput

0.479

High

131696

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

10

Small-scale

0.479

High

159486

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

2

High-throughput

0.479

High

315056

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

317784

LTN1
E3 ubiquitin-protein ligase listerin

1

3

High-throughput

0.479

High

325662

UBR5
E3 ubiquitin-protein ligase UBR5

1

13

Small-scale

0.479

High

362670

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.479

High

400199

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

411262

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

415307

HSPB1
Heat shock protein beta-1

1

2

Small-scale

0.479

High

446594

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

507470

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.479

High

536384

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

547087

ARF4
ADP-ribosylation factor 4

1

11

High-throughput

0.479

High

547094

1433T
14-3-3 protein theta

1

6

High-throughput

0.479

High

547096

PML
Protein PML

1

10

High-throughput

0.479

High

547098

HSP74
Heat shock 70 kDa protein 4

1

12

Small-scale

0.479

High

547100

TRI23
E3 ubiquitin-protein ligase TRIM23

1

16

High-throughput

0.479

High

547105

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

547107

YAP1
Transcriptional coactivator YAP1

1

17

High-throughput

0.479

High

547110

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

High-throughput

0.479

High

547111

ARL4D
ADP-ribosylation factor-like protein 4D

1

18

High-throughput

0.479

High

547114

CDK7
Cyclin-dependent kinase 7

1

7

High-throughput

0.479

High

547116

ATX3
Ataxin-3

1

2

High-throughput

0.479

High

547118

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

2

High-throughput

0.479

High

547119

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

Small-scale

0.479

High

547122

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

Small-scale

0.479

High

547123

ARF3
ADP-ribosylation factor 3

1

11

High-throughput

0.479

High

547125

RBX1
E3 ubiquitin-protein ligase RBX1

1

6

High-throughput

0.479

High

547127

DYLT1
Dynein light chain Tctex-type 1

1

3

High-throughput

0.479

High

547128

SSBP2
Single-stranded DNA-binding protein 2

1

2

Small-scale

0.479

High

547129

ARF5
ADP-ribosylation factor 5

1

11

High-throughput

0.479

High

547132

VIGLN
Vigilin

1

2

High-throughput

0.479

High

547138

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

3

High-throughput

0.479

High

547141

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

547142

HDAC1
Histone deacetylase 1

1

11

High-throughput

0.479

High

547143

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

547144

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

547147

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

547148

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

547149

DCAF6
DDB1- and CUL4-associated factor 6

1

16

High-throughput

0.479

High

547152

DCA15
DDB1- and CUL4-associated factor 15

1

4

High-throughput

0.479

High

547153

ZN746
Zinc finger protein 746

1

4

High-throughput

0.479

High

547156

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

547157

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

547160

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

12

High-throughput

0.479

High

547161

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

547163

HOOK3
Protein Hook homolog 3

1

8

High-throughput

0.479

High

547165

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

547168

WDTC1
WD and tetratricopeptide repeats protein 1

1

18

High-throughput

0.479

High

547170

ARL10
ADP-ribosylation factor-like protein 10

1

18

High-throughput

0.479

High

547171

KDF1
Keratinocyte differentiation factor 1

1

1

High-throughput

0.479

High

547178

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

547181

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

High-throughput

0.479

High

547182

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

547184

FBXW7
F-box/WD repeat-containing protein 7

1

15

High-throughput

0.479

High

547185

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

547186

FBXW5
F-box/WD repeat-containing protein 5

1

2

High-throughput

0.479

High

547194

RUFY1
RUN and FYVE domain-containing protein 1

1

4

High-throughput

0.479

High

547195

NECD
Necdin

1

3

High-throughput

0.479

High

547201

ATG5
Autophagy protein 5

1

2

High-throughput

0.479

High

547203

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

547208

BRD7
Bromodomain-containing protein 7

1

3

High-throughput

0.479

High

547209

ANLN
Anillin

1

2

High-throughput

0.479

High

547210

SAR1A
Small COPII coat GTPase SAR1A

1

20

High-throughput

0.479

High

547214

HECW2
E3 ubiquitin-protein ligase HECW2

1

12

High-throughput

0.479

High

547217

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

547218

TES
Testin

1

1

High-throughput

0.479

High

547220

HOOK1
Protein Hook homolog 1

1

8

High-throughput

0.479

High

547221

RCOR1
REST corepressor 1

1

5

High-throughput

0.479

High

547223

FBW1A
F-box/WD repeat-containing protein 1A

1

14

High-throughput

0.479

High

547225

KLK5
Kallikrein-5

1

2

High-throughput

0.479

High

547227

ARL5A
ADP-ribosylation factor-like protein 5A

1

20

High-throughput

0.479

High

547228

SAR1B
Small COPII coat GTPase SAR1B

1

20

High-throughput

0.479

High

547145

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

547172

DTWD2
tRNA-uridine aminocarboxypropyltransferase 2

1

0

High-throughput

0.458

High

547176

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.458

High

295561

CIB2
Calcium and integrin-binding family member 2

1

2

High-throughput

0.445

High

457194

TBB5
Tubulin beta chain

1

3

High-throughput

0.445

High

528953

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

547088

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

8

High-throughput

0.445

High

547097

1433S
14-3-3 protein sigma

1

7

High-throughput

0.445

High

547113

ERF
ETS domain-containing transcription factor ERF

1

2

High-throughput

0.445

High

547137

IFT88
Intraflagellar transport protein 88 homolog

1

3

High-throughput

0.445

High

547151

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.445

High

547174

DNJB8
DnaJ homolog subfamily B member 8

1

6

High-throughput

0.445

High

547204

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.445

High

547216

DNJB9
DnaJ homolog subfamily B member 9

1

4

High-throughput

0.445

High

547222

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

547229

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

15

High-throughput

0.445

High

105207

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

239692

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

246411

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.437

High

316736

MTA2
Metastasis-associated protein MTA2

1

5

High-throughput

0.437

High

352896

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

371030

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

378946

PIGR
Polymeric immunoglobulin receptor

1

4

Small-scale

0.437

High

543405

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

5

High-throughput

0.437

High

547084

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

547095

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

547099

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

547101

CEAM6
Cell adhesion molecule CEACAM6

1

5

High-throughput

0.437

High

547109

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

547112

TSP3
Thrombospondin-3

1

1

High-throughput

0.437

High

547124

H4
Histone H4

1

5

High-throughput

0.437

High

547139

TIF1B
Transcription intermediary factor 1-beta

1

12

High-throughput

0.437

High

547158

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

4

Small-scale

0.437

High

547159

DET1
DET1 homolog

1

4

High-throughput

0.437

High

547166

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.437

High

547177

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.437

High

547187

PF21A
PHD finger protein 21A

1

6

High-throughput

0.437

High

547198

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

547200

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.437

High

547212

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

547154

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

547207

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.426

High

547215

UXT
Protein UXT

1

0

Small-scale

0.426

High

330026

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

346756

CER1
Cerberus

1

1

High-throughput

0.407

High

466858

ACM4
Muscarinic acetylcholine receptor M4

1

1

High-throughput

0.407

High

547089

KLK2
Kallikrein-2

1

5

High-throughput

0.407

High

547091

GRAH
Granzyme H

1

6

High-throughput

0.407

High

547120

GMFB
Glia maturation factor beta

1

1

High-throughput

0.407

High

547188

ESPB1
Epididymal sperm-binding protein 1

1

2

High-throughput

0.407

High

547199

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

547133

DEF5
Defensin alpha 5

3

0

High-throughput

0.345

High

547191

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

73767

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

0

High-throughput

0.279

Low

547090

TRYB2
Tryptase beta-2

1

0

High-throughput

0.279

Low

547121

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.279

Low

547164

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

547175

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

547213

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

136798

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.249

Low

458255

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.249

Low

547167

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

547180

DNS2B
Deoxyribonuclease-2-beta

1

0

High-throughput

0.249

Low

342499

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.232

Low

547179

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.232

Low

547192

FACOS
FANCD2 opposite strand protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025