HitPredict

Interactor 1: UBC18 (Q21633)
Ubiquitin-conjugating enzyme E2 ubc-18 (EC 2.3.2.23)
Gene: ubc-18

Interactor 2: Q9XUS3 (Q9XUS3)
E3 ubiquitin-protein ligase parkin (EC 2.3.2.31)
Gene: pdr-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.50 1.00 0.713

The method score is based on:

Property Details
Experiments 16204351
Identification Methods two hybrid, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains IBR~UQ_con, UQ_con~zf-RING_14
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008340 - determination of adult lifespan
GO:0016567 - protein ubiquitination
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 153
Ce

1 386
+ Ce
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sc
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024