HitPredict

Interactor 1: AAPK1 (Q13131)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: PRKAA1

Interactor 2: SIK3 (Q9Y2K2)
Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)
Gene: SIK3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16306228
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AdenylateSensor~Pkinase, AMPK_alpha_AID~Pkinase, Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0006468 - protein phosphorylation GO:0050321 - tau-protein kinase activity and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 559 Hs			1 1321
+	Hs
		692053 AAPK1_HUMAN (1-559): 0: 590: 100.00		MARK3_HUMAN (1-706): 5.66e-155: 487: 31.29
+	Hs
		1095454 AAPK1_HUMAN (1-559): 0: 590: 100.00		SIK2_HUMAN (50-831): 2.4e-151: 482: 34.92
+	Hs
		1095399 AAPK1_HUMAN (1-559): 0: 590: 100.00		MARK2_HUMAN (15-704): 8.01e-144: 458: 30.93
+	Hs
		1095439 AAPK1_HUMAN (1-559): 0: 590: 100.00		MARK4_HUMAN (1-716): 1.71e-142: 453: 30.76
+	Hs
		943644 AAPK1_HUMAN (1-559): 0: 590: 100.00		SIK1_HUMAN (50-800): 7.05e-138: 442: 32.42
+	Hs
		1095466 AAPK1_HUMAN (1-559): 0: 590: 100.00		SNRK_HUMAN (52-427): 1.21e-137: 441: 38.85
+	Hs
		930687 AAPK1_HUMAN (1-559): 0: 590: 100.00		AAPK2_HUMAN (52-597): 1.39e-138: 436: 30.13
+	Hs
		930663 AAPK2_HUMAN (13-559): 0: 532: 75.41		AAPK2_HUMAN (52-597): 1.39e-138: 436: 30.13
+	Hs
		1095471 AAPK1_HUMAN (1-559): 0: 590: 100.00		MARK1_HUMAN (41-382): 1.93e-105: 354: 55.43
+	At
		1182685 KIN10_ARATH (26-454): 3.69e-162: 473: 50.35		KIN10_ARATH (51-436): 1.3e-148: 461: 38.52
+	Hs
		692086 MARK2_HUMAN (10-545): 4.73e-148: 446: 29.46		MARK3_HUMAN (1-706): 5.66e-155: 487: 31.29
+	At
		1020112 KIN10_ARATH (26-454): 3.69e-162: 473: 50.35		KIN11_ARATH (65-419): 1.54e-144: 450: 41.29
+	At
		1057378 KIN10_ARATH (26-454): 3.69e-162: 473: 50.35		CDPK1_ARATH (2-504): 5.92e-143: 450: 23.40
+	Rn
		148075 MARK2_RAT (3-543): 9.22e-149: 446: 29.95		MARK2_RAT (15-704): 4.97e-148: 467: 31.59
+	Hs
		1270457 MARK2_HUMAN (10-545): 4.73e-148: 446: 29.46		MARK2_HUMAN (15-704): 8.01e-144: 458: 30.93
+	At
		1180623 CIPK3_ARATH (16-498): 4.83e-153: 447: 31.89		CIPK3_ARATH (55-470): 3.49e-146: 452: 32.16
+	Zm
		45244 A0A1D6QH07_MAIZE (15-510): 7.85e-153: 447: 28.93		A0A1D6QH07_MAIZE (54-464): 6.58e-146: 452: 30.51
+	Hs
		275429 MARK2_HUMAN (10-545): 4.73e-148: 446: 29.46		O75271_HUMAN (1-436): 1.19e-138: 433: 42.56
+	Hs
		1095405 AAPK1_HUMAN (1-559): 0: 590: 100.00		BRSK2_HUMAN (63-398): 9.47e-78: 275: 43.49