HitPredict

Interactor 1: PAPP1 (Q13219)
Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A)
Gene: PAPPA

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.50	0.464

Property	Details
Experiments	15231748
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1627 Hs			1 467
+	Hs
		1014494 PAPP1_HUMAN (1-1627): 0: 2175: 100.00		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		181884 PAPP1_HUMAN (1-1627): 0: 2175: 100.00		SMAD9_HUMAN (1-467): 0: 564: 54.56
+	Hs
		1106693 PAPP2_HUMAN (97-1616): 0: 1915: 45.66		SMAD4_HUMAN (11-456): 4.55e-151: 443: 31.58
+	Hs
		472294 CFAH_HUMAN (1173-1563): 9.53e-38: 157: 14.13		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		1014583 CSMD1_HUMAN (927-1345): 4.52e-21: 103: 13.84		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		1014530 SVEP1_HUMAN (1212-1620): 6.2e-15: 83.3: 10.50		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		857411 NOTC1_HUMAN (1351-1622): 8.43e-10: 66.4: 11.93		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		181895 SVEP1_HUMAN (1212-1620): 6.2e-15: 83.3: 10.50		SMAD9_HUMAN (1-467): 0: 564: 54.56
+	Hs
		1047555 NOTC2_HUMAN (1353-1622): 5.56e-10: 66.7: 11.91		SMAD1_HUMAN (1-467): 0: 565: 55.53
+	Hs
		181861 NOTC1_HUMAN (1351-1622): 8.43e-10: 66.4: 11.93		SMAD9_HUMAN (1-467): 0: 564: 54.56
+	Hs
		1047535 NOTC2_HUMAN (1353-1622): 5.56e-10: 66.7: 11.91		SMAD4_HUMAN (11-456): 4.55e-151: 443: 31.58