Protein: PAPP1
Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A)

Gene: PAPP1, PAPPA
Organism: Homo sapiens
Interactions: 14
UniProt ID: Q13219

Gene Ontology (top 5):
GO:0004222 - metalloendopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006508 - proteolysis
GO:0007166 - cell surface receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

567847

PRG2
Bone marrow proteoglycan

3

16

Small-scale

0.662

High

366347

PLMN
Plasminogen

1

14

Small-scale

0.647

High

1014494

SMAD3
Mothers against decapentaplegic homolog 3

1

11

High-throughput

0.508

High

914823

STC1
Stanniocalcin-1

1

1

Small-scale

0.501

High

1098514

CBP
CREB-binding protein

1

7

Small-scale

0.481

High

1098511

PLEC
Plectin

1

4

High-throughput

0.470

High

181884

SMAD9
Mothers against decapentaplegic homolog 9

1

11

High-throughput

0.464

High

555475

SKIL
Ski-like protein

1

1

High-throughput

0.464

High

1098512

SMAD2
Mothers against decapentaplegic homolog 2

1

11

High-throughput

0.464

High

379244

IGHG1
Immunoglobulin heavy constant gamma 1

1

6

High-throughput

0.445

High

379512

IGHM
Immunoglobulin heavy constant mu

1

5

High-throughput

0.445

High

1098515

KLH20
Kelch-like protein 20

1

2

Small-scale

0.439

High

1098513

MCAF1
Activating transcription factor 7-interacting protein 1

1

4

High-throughput

0.417

High

591630

H2AX
Histone H2AX

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025