Protein: CFAH
Complement factor H (H factor 1)

Gene: CFAH, CFH
Organism: Homo sapiens
Interactions: 140
UniProt ID: P08603

Gene Ontology (top 5):
GO:0001851 - complement component C3b binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006508 - proteolysis
GO:0006956 - complement activation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369813

CO3
Complement C3

8

17

Small-scale

0.971

High

472297

FHR3
Complement factor H-related protein 3

2

16

High-throughput

0.802

High

472264

CFAH
Complement factor H

2

14

Small-scale

0.768

High

388483

CRP

9

6

Small-scale

0.760

High

132986

MATN2
Matrilin-2

1

14

High-throughput

0.691

High

210690

KLK10
Kallikrein-10

1

13

High-throughput

0.691

High

472268

LYAM1
L-selectin

1

12

Small-scale

0.647

High

472267

BMP1
Bone morphogenetic protein 1

1

10

Small-scale

0.618

High

472308

LRP8
Low-density lipoprotein receptor-related protein 8

1

9

Small-scale

0.618

High

472277

PTX3
Pentraxin-related protein PTX3

2

6

Small-scale

0.611

High

449588

KLK1
Kallikrein-1

1

15

Small-scale

0.575

High

320812

KLH18
Kelch-like protein 18

2

2

High-throughput

0.567

High

387360

APOE
Apolipoprotein E

1

0

Small-scale

0.564

High

389932

ALBU
Albumin

1

2

High-throughput

0.536

High

472270

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

472292

GRB2
Growth factor receptor-bound protein 2

1

8

High-throughput

0.508

High

472266

VDR
Vitamin D3 receptor

1

2

High-throughput

0.494

High

472307

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.494

High

472334

RSPH1
Radial spoke head 1 homolog

1

1

High-throughput

0.494

High

472281

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.489

High

472317

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

2

High-throughput

0.489

High

472339

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

2

High-throughput

0.489

High

472340

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

472348

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

4

High-throughput

0.489

High

472363

PHF11
PHD finger protein 11

1

2

High-throughput

0.489

High

472364

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.489

High

472370

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

137024

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

1

Small-scale

0.479

High

270302

WDR1
WD repeat-containing protein 1

1

1

Small-scale

0.479

High

472273

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

5

Small-scale

0.479

High

472279

LCN1
Lipocalin-1

1

1

Small-scale

0.479

High

472280

PRDX2
Peroxiredoxin-2

1

2

Small-scale

0.479

High

472286

PSB3
Proteasome subunit beta type-3

1

1

Small-scale

0.479

High

472311

PDIA6
Protein disulfide-isomerase A6

1

1

Small-scale

0.479

High

472314

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

1

Small-scale

0.479

High

472333

SYNE2
Nesprin-2

1

5

Small-scale

0.479

High

472342

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

3

Small-scale

0.479

High

472349

GTPB2
GTP-binding protein 2

1

1

Small-scale

0.479

High

472367

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

1

Small-scale

0.479

High

472372

MTCL1
Microtubule cross-linking factor 1

1

3

Small-scale

0.479

High

123561

MYO1C
Unconventional myosin-Ic

1

0

Small-scale

0.458

High

472276

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

472278

PSB6
Proteasome subunit beta type-6

1

0

Small-scale

0.458

High

472296

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

Small-scale

0.458

High

472300

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.458

High

472313

P3H1
Prolyl 3-hydroxylase 1

1

0

Small-scale

0.458

High

472337

UCN3
Urocortin-3

1

0

Small-scale

0.458

High

472352

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

0

Small-scale

0.458

High

472294

SMAD3
Mothers against decapentaplegic homolog 3

1

10

High-throughput

0.439

High

472302

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.439

High

61404

VWA8
von Willebrand factor A domain-containing protein 8

1

2

Small-scale

0.437

High

143383

E2F3
Transcription factor E2F3

1

1

Small-scale

0.437

High

217739

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.437

High

219683

FOXO3
Forkhead box protein O3

1

4

Small-scale

0.437

High

277257

PITX3
Pituitary homeobox 3

1

2

Small-scale

0.437

High

318945

MICA2
[F-actin]-monooxygenase MICAL2

1

5

Small-scale

0.437

High

323928

CMTA2
Calmodulin-binding transcription activator 2

1

1

Small-scale

0.437

High

330403

LC7L3
Luc7-like protein 3

1

1

Small-scale

0.437

High

472265

SPTB1
Spectrin beta chain, erythrocytic

1

4

Small-scale

0.437

High

472269

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

Small-scale

0.437

High

472271

EPHA1
Ephrin type-A receptor 1

1

6

High-throughput

0.437

High

472275

MCM3
DNA replication licensing factor MCM3

1

1

Small-scale

0.437

High

472284

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

2

Small-scale

0.437

High

472295

VIGLN
Vigilin

1

1

Small-scale

0.437

High

472298

DYST
Dystonin

1

5

Small-scale

0.437

High

472301

ZO1
Tight junction protein 1

1

3

Small-scale

0.437

High

472303

FOXO1
Forkhead box protein O1

1

3

High-throughput

0.437

High

472305

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

2

Small-scale

0.437

High

472306

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

6

Small-scale

0.437

High

472309

TFDP1
Transcription factor Dp-1

1

1

Small-scale

0.437

High

472310

TFDP2
Transcription factor Dp-2

1

1

Small-scale

0.437

High

472312

E2F4
Transcription factor E2F4

1

1

Small-scale

0.437

High

472315

SH319
SH3 domain-containing protein 19

1

4

Small-scale

0.437

High

472316

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

Small-scale

0.437

High

472319

ANR12
Ankyrin repeat domain-containing protein 12

1

5

Small-scale

0.437

High

472320

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

2

Small-scale

0.437

High

472321

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

1

Small-scale

0.437

High

472322

BRAP
BRCA1-associated protein

1

2

Small-scale

0.437

High

472323

MGAP
MAX gene-associated protein

1

1

Small-scale

0.437

High

472324

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

1

Small-scale

0.437

High

472325

NALCN
Sodium leak channel NALCN

1

3

Small-scale

0.437

High

472330

ARH40
Rho guanine nucleotide exchange factor 40

1

1

Small-scale

0.437

High

472335

S39A7
Zinc transporter SLC39A7

1

1

Small-scale

0.437

High

472344

CC136
Coiled-coil domain-containing protein 136

1

3

Small-scale

0.437

High

472357

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

Small-scale

0.437

High

472358

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

1

Small-scale

0.437

High

472359

RAI14
Ankycorbin

1

10

Small-scale

0.437

High

472361

SEPT9
Septin-9

1

1

Small-scale

0.437

High

472362

PUF60
Poly(U)-binding-splicing factor PUF60

1

3

Small-scale

0.437

High

472365

F184B
Protein FAM184B

1

3

Small-scale

0.437

High

472366

G3BP2
Ras GTPase-activating protein-binding protein 2

1

1

Small-scale

0.437

High

472369

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

1

Small-scale

0.437

High

472371

LC7L2
Putative RNA-binding protein Luc7-like 2

1

1

Small-scale

0.437

High

472373

ASB1
Ankyrin repeat and SOCS box protein 1

1

2

Small-scale

0.437

High

431496

AP2A
Transcription factor AP-2-alpha

1

3

High-throughput

0.417

High

472336

AP2C
Transcription factor AP-2 gamma

1

3

High-throughput

0.417

High

472343

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

472272

MUTA
Methylmalonyl-CoA mutase, mitochondrial

1

0

High-throughput

0.279

Low

472289

STX17
Syntaxin-17

1

0

High-throughput

0.279

Low

472329

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.279

Low

472350

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

472354

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.279

Low

472299

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.251

Low

472346

YTDC1
YTH domain-containing protein 1

1

0

High-throughput

0.251

Low

66113

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

Small-scale

0.249

Low

73987

MYO9A
Unconventional myosin-IXa

1

0

Small-scale

0.249

Low

136587

MANBA
Beta-mannosidase

1

0

Small-scale

0.249

Low

276558

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

Small-scale

0.249

Low

298568

RAD17
Cell cycle checkpoint protein RAD17

1

0

Small-scale

0.249

Low

442547

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.249

Low

472274

LORI
Loricrin

1

0

Small-scale

0.249

Low

472282

MCM5
DNA replication licensing factor MCM5

1

0

Small-scale

0.249

Low

472283

T2FA
General transcription factor IIF subunit 1

1

0

Small-scale

0.249

Low

472285

SRP09
Signal recognition particle 9 kDa protein

1

0

Small-scale

0.249

Low

472287

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.249

Low

472288

PGTB2
Geranylgeranyl transferase type-2 subunit beta

1

0

Small-scale

0.249

Low

472290

TMM33
Transmembrane protein 33

1

0

Small-scale

0.249

Low

472291

PSME3
Proteasome activator complex subunit 3

1

0

Small-scale

0.249

Low

472293

MAP1A
Microtubule-associated protein 1A

1

0

Small-scale

0.249

Low

472304

TF3C1
General transcription factor 3C polypeptide 1

1

0

Small-scale

0.249

Low

472318

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

Small-scale

0.249

Low

472326

INT1
Integrator complex subunit 1

1

0

Small-scale

0.249

Low

472327

SEN2
tRNA-splicing endonuclease subunit Sen2

1

0

Small-scale

0.249

Low

472328

CI043
Uncharacterized protein C9orf43

1

0

Small-scale

0.249

Low

472331

CATIN
Splicing factor Cactin

1

0

Small-scale

0.249

Low

472332

SEN15
tRNA-splicing endonuclease subunit Sen15

1

0

Small-scale

0.249

Low

472338

TF3C6
General transcription factor 3C polypeptide 6

1

0

Small-scale

0.249

Low

472341

SYNM
Asparaginyl-tRNA synthetase

1

0

Small-scale

0.249

Low

472345

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

1

0

Small-scale

0.249

Low

472347

WRIP1
ATPase WRNIP1

1

0

Small-scale

0.249

Low

472351

STEEP
STING ER exit protein

1

0

Small-scale

0.249

Low

472353

NCK5L
Nck-associated protein 5-like

1

0

Small-scale

0.249

Low

472355

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

Small-scale

0.249

Low

472356

SPS2L
SPATS2-like protein

1

0

Small-scale

0.249

Low

472360

SLAI2
SLAIN motif-containing protein 2

1

0

Small-scale

0.249

Low

472368

SMC3
Structural maintenance of chromosomes protein 3

1

0

Small-scale

0.249

Low

472374

TF3C5
General transcription factor 3C polypeptide 5

1

0

Small-scale

0.249

Low

472375

FHOD1
FH1/FH2 domain-containing protein 1

1

0

Small-scale

0.249

Low

261060

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025