HitPredict

Interactor 1: PSA2 (Q27488)
Proteasome subunit alpha type-2 (Proteasome subunit alpha 2)
Gene: pas-2

Interactor 2: PSA7 (Q95005)
Proteasome subunit alpha type-7 (Proteasome subunit alpha 4)
Gene: pas-4

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	12679813, 14704431, 11559592, 18692475, unassigned701
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N, Proteasome_A_N~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0019773 - proteasome core complex, alpha-subunit complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 231 Ce			1 253
+	Dm
		771303 PSA2_DROME (2-231): 4.04e-109: 314: 60.52		PSA5_DROME (2-237): 5.33e-95: 280: 32.92
+	Hs
		156266 PSA6_HUMAN (2-231): 5.65e-102: 297: 32.77		PSA7_HUMAN (1-234): 5.28e-99: 290: 63.25
+	Dm
		611631 PSA2_DROME (2-231): 4.04e-109: 314: 60.52		PSA71_DROME (2-233): 5.15e-92: 273: 58.62
+	Sp
		293714 PSA2_SCHPO (1-231): 2.13e-104: 303: 53.85		PSA3_SCHPO (1-242): 1.21e-91: 272: 32.79
+	Hs
		656189 PSA6_HUMAN (2-231): 5.65e-102: 297: 32.77		PSA5_HUMAN (2-236): 1.12e-93: 277: 34.17
+	Hs
		638100 PSA6_HUMAN (2-231): 5.65e-102: 297: 32.77		PSA4_HUMAN (1-233): 2.63e-92: 274: 32.49
+	Hs
		893636 PSA6_HUMAN (2-231): 5.65e-102: 297: 32.77		PSA6_HUMAN (1-240): 3.01e-92: 273: 32.11
+	Sc
		619428 PSA2_YEAST (1-231): 1.88e-100: 293: 51.79		PSA5_YEAST (2-248): 4.19e-93: 276: 32.81
+	Hs
		156230 PSA5_HUMAN (3-231): 3.82e-90: 266: 28.57		PSA7_HUMAN (1-234): 5.28e-99: 290: 63.25
+	Sp
		293716 PSA2_SCHPO (1-231): 2.13e-104: 303: 53.85		PSA4_SCHPO (1-252): 1.56e-81: 246: 50.59
+	Dm
		611647 PSA5_DROME (3-231): 4.28e-92: 272: 31.67		PSA71_DROME (2-233): 5.15e-92: 273: 58.62
+	Hv
		1358195 PSA1_HALVD (5-230): 2.37e-90: 268: 34.63		PSA1_HALVD (4-252): 4.72e-93: 275: 36.55
+	Hs
		656149 PSA5_HUMAN (3-231): 3.82e-90: 266: 28.57		PSA5_HUMAN (2-236): 1.12e-93: 277: 34.17
+	Hs
		638067 PSA5_HUMAN (3-231): 3.82e-90: 266: 28.57		PSA4_HUMAN (1-233): 2.63e-92: 274: 32.49
+	Sc
		619476 PSA2_YEAST (1-231): 1.88e-100: 293: 51.79		PSA4_YEAST (1-229): 3.16e-79: 240: 54.70
+	Sp
		1013784 PSA5_SCHPO (3-229): 3.21e-91: 269: 30.38		PSA4_SCHPO (1-252): 1.56e-81: 246: 50.59
+	Hs
		637663 PSA6_HUMAN (2-231): 5.65e-102: 297: 32.77		PSA2_HUMAN (4-186): 1.92e-42: 145: 39.34
+	Hs
		637631 PSA5_HUMAN (3-231): 3.82e-90: 266: 28.57		PSA2_HUMAN (4-186): 1.92e-42: 145: 39.34