HitPredict

Interactor 1: BIK (Q13323)
Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4)
Gene: BIK

Interactor 2: B2CL2 (Q92843)
Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W)
Gene: BCL2L2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

Property	Details
Experiments	30217970, 27107012, 32296183, 25416956, 16697956, 10381646, unassigned1304, 15694340
Identification Methods	two hybrid, unspecified method, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, barcode fusion genetics two hybrid, split luciferase complementation, validated two hybrid, fluorescence polarization spectroscopy, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042981 - regulation of apoptotic process GO:0097136 - Bcl-2 family protein complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 160 Hs			1 193
+	Hs
		522086 BIK_HUMAN (1-160): 3.78e-101: 288: 100.00		BCL2_HUMAN (9-193): 1.76e-61: 192: 35.32
+	Hs
		1060162 BIK_HUMAN (1-160): 3.78e-101: 288: 100.00		B2CL1_HUMAN (6-185): 1.45e-56: 179: 38.96
+	Hs
		1060255 BIK_HUMAN (1-160): 3.78e-101: 288: 100.00		MCL1_HUMAN (19-180): 6.39e-46: 156: 21.82
+	Hs
		1102394 BIK_HUMAN (1-160): 3.78e-101: 288: 100.00		B2LA1_HUMAN (20-152): 1.25e-41: 139: 19.29
+	Hs
		1102457 BIK_HUMAN (1-160): 3.78e-101: 288: 100.00		B2L10_HUMAN (1-180): 1.24e-32: 117: 21.50
+	Hs
		3216 BIK_HUMAN (1-160): 3.78e-101: 288: 100.00		A0A0S2Z3D2_HUMAN (6-82): 6.99e-12: 62.5: 31.75