Protein: B2CL1
Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)

Gene: B2CL1, BCL2L1
Organism: Homo sapiens
Interactions: 205
UniProt ID: Q07817

Gene Ontology (top 5):
GO:0001541 - ovarian follicle development
GO:0001701 - in utero embryonic development
GO:0001836 - release of cytochrome c from mitochondria
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1060198

BAD
Bcl2-associated agonist of cell death

40

8

Small-scale

0.995

High

1060079

BAX
Apoptosis regulator BAX

33

18

Small-scale

0.994

High

1060173

BAK
Bcl-2 homologous antagonist/killer

23

17

Small-scale

0.991

High

219621

B2L11
Bcl-2-like protein 11

23

17

Small-scale

0.990

High

1060168

BECN1
Beclin-1

17

8

Small-scale

0.988

High

413697

P53
Cellular tumor antigen p53

11

9

Small-scale

0.984

High

939616

BID
BH3-interacting domain death agonist

10

10

Small-scale

0.973

High

1060207

BMF
Bcl-2-modifying factor

7

8

Small-scale

0.963

High

1060217

BBC3
Bcl-2-binding component 3, isoforms 1/2

6

7

Small-scale

0.948

High

522078

BCL2
Apoptosis regulator Bcl-2

6

17

Small-scale

0.946

High

1060165

APR
Phorbol-12-myristate-13-acetate-induced protein 1

4

7

Small-scale

0.885

High

241490

PRKN
E3 ubiquitin-protein ligase parkin

3

7

Small-scale

0.876

High

1060155

B2CL1
Bcl-2-like protein 1

3

17

Small-scale

0.861

High

1060164

ASPP2
Apoptosis-stimulating of p53 protein 2

2

3

Small-scale

0.826

High

1060220

NLRP1
NACHT, LRR and PYD domains-containing protein 1

2

2

Small-scale

0.812

High

1060162

BIK
Bcl-2-interacting killer

12

6

Small-scale

0.760

High

161714

APAF
Apoptotic protease-activating factor 1

2

1

Small-scale

0.754

High

126017

HRK
Activator of apoptosis harakiri

7

4

Small-scale

0.746

High

1060156

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

16

Small-scale

0.737

High

1060210

BBC3B
Bcl-2-binding component 3, isoforms 3/4

7

5

Small-scale

0.736

High

640864

VDAC1
Non-selective voltage-gated ion channel VDAC1

5

8

Small-scale

0.726

High

505093

BNIP5
Protein BNIP5

2

2

High-throughput

0.700

High

507172

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

2

High-throughput

0.691

High

1004482

RNF4
E3 ubiquitin-protein ligase RNF4

3

2

High-throughput

0.653

High

991502

DYL1
Dynein light chain 1, cytoplasmic

3

4

Small-scale

0.650

High

1060211

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

2

Small-scale

0.648

High

186255

SIVA
Apoptosis regulatory protein Siva

2

2

Small-scale

0.646

High

839247

MTOR
Serine/threonine-protein kinase mTOR

2

1

Small-scale

0.646

High

1060175

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

3

0

High-throughput

0.638

High

903885

BAP31
B-cell receptor-associated protein 31

2

1

Small-scale

0.634

High

967685

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

11

Small-scale

0.634

High

1060218

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

8

Small-scale

0.624

High

1060213

RAD9A
Cell cycle checkpoint control protein RAD9A

2

2

Small-scale

0.620

High

712850

CASP1
Caspase-1

1

8

Small-scale

0.618

High

936941

CASP9
Caspase-9

1

8

Small-scale

0.618

High

1060232

B2L10
Bcl-2-like protein 10

1

4

Small-scale

0.618

High

692469

G0S2
G0/G1 switch protein 2

2

1

High-throughput

0.606

High

791330

SYUA
Alpha-synuclein

2

1

High-throughput

0.606

High

1060180

GORAB
RAB6-interacting golgin

2

1

High-throughput

0.606

High

1060192

CJ067
Uncharacterized protein C10orf67, mitochondrial

2

1

High-throughput

0.606

High

1060248

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

1

High-throughput

0.606

High

533650

CLUS
Clusterin

2

1

Small-scale

0.606

High

1060203

DYL2
Dynein light chain 2, cytoplasmic

2

4

High-throughput

0.601

High

1060239

WSB2
WD repeat and SOCS box-containing protein 2

2

2

High-throughput

0.601

High

1060167

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

2

2

Small-scale

0.595

High

853661

MK08
Mitogen-activated protein kinase 8

2

13

Small-scale

0.585

High

443331

CDK1
Cyclin-dependent kinase 1

2

5

Small-scale

0.584

High

929913

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

2

Small-scale

0.584

High

1060247

UBP18
Ubl carboxyl-terminal hydrolase 18

2

2

Small-scale

0.584

High

941744

TM50B
Transmembrane protein 50B

2

0

High-throughput

0.580

High

1060222

ELOV4
Very long chain fatty acid elongase 4

2

0

High-throughput

0.580

High

1060225

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.580

High

1060228

REEP4
Receptor expression-enhancing protein 4

2

0

High-throughput

0.580

High

1060201

RN183
E3 ubiquitin-protein ligase RNF183

1

1

Small-scale

0.578

High

890725

PSN2
Presenilin-2

1

4

Small-scale

0.573

High

230305

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

384404

CRYAA
Alpha-crystallin A chain

1

6

Small-scale

0.561

High

384659

CRYAB
Alpha-crystallin B chain

1

6

Small-scale

0.561

High

567384

TCTP
Translationally-controlled tumor protein

1

1

Small-scale

0.561

High

842737

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

2

Small-scale

0.561

High

1060193

BLID
BH3-like motif-containing cell death inducer

1

1

Small-scale

0.561

High

1060212

PARK7
Parkinson disease protein 7

1

1

Small-scale

0.561

High

1060181

RHBD2
Rhomboid domain-containing protein 2

2

1

High-throughput

0.553

High

1060160

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

1

5

Small-scale

0.552

High

1060174

RTN1
Reticulon-1

1

3

Small-scale

0.552

High

1060234

RTN4
Reticulon-4

1

3

Small-scale

0.552

High

1060236

AVEN
Cell death regulator Aven

1

1

Small-scale

0.552

High

1060244

IKZF3
Zinc finger protein Aiolos

1

1

Small-scale

0.552

High

1060187

GLT10
Polypeptide N-acetylgalactosaminyltransferase 10

2

1

High-throughput

0.549

High

578464

BRAF
Serine/threonine-protein kinase B-raf

1

3

High-throughput

0.549

High

457386

TBB5
Tubulin beta chain

2

0

High-throughput

0.547

High

67164

ZAR1L
Protein ZAR1-like

1

1

High-throughput

0.536

High

1060178

MBRL
Membralin

1

1

High-throughput

0.536

High

1060249

KLH20
Kelch-like protein 20

1

1

High-throughput

0.536

High

1060250

MTCH2
Mitochondrial carrier homolog 2

1

4

High-throughput

0.536

High

1060171

RYR3
Ryanodine receptor 3

1

5

Small-scale

0.523

High

362261

ABL1
Tyrosine-protein kinase ABL1

1

3

Small-scale

0.515

High

786563

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

11

High-throughput

0.515

High

1060226

SPNS1
Protein spinster homolog 1

1

1

Small-scale

0.515

High

1060177

ANO6
Anoctamin-6

1

0

High-throughput

0.513

High

1060215

FUND2
FUN14 domain-containing protein 2

1

0

High-throughput

0.513

High

889972

PSN1
Presenilin-1

1

4

Small-scale

0.508

High

913921

RBM5
RNA-binding protein 5

1

1

High-throughput

0.508

High

952772

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.508

High

1060229

B2L12
Bcl-2-like protein 12

1

2

Small-scale

0.508

High

1060230

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

2

High-throughput

0.508

High

163091

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.501

High

170103

AURKA
Aurora kinase A

1

5

Small-scale

0.501

High

239363

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

5

Small-scale

0.501

High

400708

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

Small-scale

0.501

High

728193

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

Small-scale

0.501

High

853780

MK09
Mitogen-activated protein kinase 9

1

13

Small-scale

0.501

High

879711

MAPK2
MAP kinase-activated protein kinase 2

1

1

Small-scale

0.501

High

891134

GSK3A
Glycogen synthase kinase-3 alpha

1

9

Small-scale

0.501

High

891486

GSK3B
Glycogen synthase kinase-3 beta

1

9

Small-scale

0.501

High

902828

BLK
Tyrosine-protein kinase Blk

1

3

Small-scale

0.501

High

919908

PLK1
Serine/threonine-protein kinase PLK1

1

3

Small-scale

0.501

High

1060159

SEC20
Vesicle transport protein SEC20

1

1

Small-scale

0.501

High

1060172

MK14
Mitogen-activated protein kinase 14

1

14

Small-scale

0.501

High

1060227

PLK3
Serine/threonine-protein kinase PLK3

1

1

Small-scale

0.501

High

1060189

VRK2
Serine/threonine-protein kinase VRK2

1

3

Small-scale

0.500

High

1060224

ATG5
Autophagy protein 5

1

0

Small-scale

0.493

High

482452

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.486

High

566647

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.486

High

636725

PTN
Pleiotrophin

1

0

High-throughput

0.486

High

880905

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.486

High

1047801

TLE1
Transducin-like enhancer protein 1

1

0

High-throughput

0.486

High

1060182

LARP1
La-related protein 1

1

0

High-throughput

0.486

High

1060188

MET23
Histone-arginine methyltransferase METTL23

1

0

High-throughput

0.486

High

1060191

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.486

High

1060196

PPHLN
Periphilin-1

1

0

High-throughput

0.486

High

1060231

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.486

High

1060184

BOP
Protein Bop

1

6

Small-scale

0.484

High

993521

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.481

High

1060157

VAC14
Protein VAC14 homolog

1

2

High-throughput

0.481

High

1060185

BNIPL
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

1

3

Small-scale

0.481

High

123676

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.479

High

135184

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

2

High-throughput

0.479

High

135596

DNM1L
Dynamin-1-like protein

1

3

Small-scale

0.479

High

159191

ABLM1
Actin-binding LIM protein 1

1

3

High-throughput

0.479

High

193006

CFLAR
CASP8 and FADD-like apoptosis regulator

1

8

Small-scale

0.479

High

209541

SERA
D-3-phosphoglycerate dehydrogenase

1

1

High-throughput

0.479

High

375448

RASK
GTPase KRas

1

6

High-throughput

0.479

High

408831

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

415524

HSPB1
Heat shock protein beta-1

1

6

High-throughput

0.479

High

532539

CH60
60 kDa heat shock protein, mitochondrial

1

7

High-throughput

0.479

High

577727

PLAK
Junction plakoglobin

1

1

High-throughput

0.479

High

690938

1433T
14-3-3 protein theta

1

4

High-throughput

0.479

High

764696

CTNB1
Catenin beta-1

1

1

High-throughput

0.479

High

772491

IRS1
Insulin receptor substrate 1

1

3

Small-scale

0.479

High

852733

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

8

High-throughput

0.479

High

890456

RBP2
E3 SUMO-protein ligase RanBP2

1

3

High-throughput

0.479

High

926962

ATX3
Ataxin-3

1

1

Small-scale

0.479

High

940930

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

941412

CTBP2
C-terminal-binding protein 2

1

1

Small-scale

0.479

High

958251

ARP2
Actin-related protein 2

1

3

High-throughput

0.479

High

989725

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

1

High-throughput

0.479

High

989834

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

1

High-throughput

0.479

High

996918

TBA4A
Tubulin alpha-4A chain

1

1

High-throughput

0.479

High

1008106

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.479

High

1027403

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.479

High

1028743

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

1

High-throughput

0.479

High

1049227

1433F
14-3-3 protein eta

1

4

High-throughput

0.479

High

1060158

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

1060161

TRI32
E3 ubiquitin-protein ligase TRIM32

1

6

Small-scale

0.479

High

1060166

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

1

High-throughput

0.479

High

1060169

CASP8
Caspase-8

1

8

Small-scale

0.479

High

1060199

MOAP1
Modulator of apoptosis 1

1

2

Small-scale

0.479

High

1060216

LFG2
Protein lifeguard 2

1

4

Small-scale

0.479

High

1060221

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

Small-scale

0.479

High

1060223

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

3

High-throughput

0.479

High

1060240

BFAR
Bifunctional apoptosis regulator

1

5

Small-scale

0.479

High

1060242

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1060183

Q7KZS0
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.470

High

1060176

EDRF1
Erythroid differentiation-related factor 1

1

1

High-throughput

0.464

High

127942

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.458

High

133739

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

169524

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

High-throughput

0.458

High

336412

SVIL
Supervillin

1

0

High-throughput

0.458

High

479804

GSTP1
Glutathione S-transferase P

1

0

High-throughput

0.458

High

658131

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

697507

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.458

High

716836

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

773166

MYH10
Myosin-10

1

0

High-throughput

0.458

High

867068

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

969585

RS15A
Small ribosomal subunit protein uS8

1

0

High-throughput

0.458

High

981261

RAB1A
Ras-related protein Rab-1A

1

0

High-throughput

0.458

High

983131

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.458

High

986010

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.458

High

996118

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.458

High

1023531

CYC
Cytochrome c

1

0

Small-scale

0.458

High

1030441

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

1041498

KMT2A
Histone-lysine N-methyltransferase 2A

1

0

Small-scale

0.458

High

1060170

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

1060200

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.458

High

1060205

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

Small-scale

0.458

High

1060214

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.458

High

1060219

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

Small-scale

0.458

High

1060235

MID51
Mitochondrial dynamics protein MIEF1

1

0

Small-scale

0.458

High

1060243

C8AP2
CASP8-associated protein 2

1

0

Small-scale

0.458

High

1060246

MYO5B
Unconventional myosin-Vb

1

0

High-throughput

0.458

High

193559

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

4

Small-scale

0.445

High

908102

KS6A3
Ribosomal protein S6 kinase alpha-3

1

4

High-throughput

0.445

High

299167

FLOT1
Flotillin-1

1

1

High-throughput

0.437

High

521661

H14
Histone H1.4

1

1

High-throughput

0.437

High

1060194

RN152
E3 ubiquitin-protein ligase RNF152

1

6

Small-scale

0.437

High

1060202

GIMA5
GTPase IMAP family member 5

1

5

Small-scale

0.437

High

1060163

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

1060209

ZN830
Zinc finger protein 830

1

0

High-throughput

0.426

High

1060233

DLRB1
Dynein light chain roadblock-type 1

1

0

Small-scale

0.426

High

1060237

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

652641

GNLY
Granulysin

2

0

High-throughput

0.316

High

1060186

RIC3
Protein RIC-3

2

0

High-throughput

0.316

High

1060195

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.316

High

1060204

PLPR2
Phospholipid phosphatase-related protein type 2

1

0

High-throughput

0.279

Low

1060206

TM101
Transmembrane protein 101

1

0

High-throughput

0.279

Low

1060190

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.265

Low

1060208

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.265

Low

1060241

ZN219
Zinc finger protein 219

1

0

High-throughput

0.265

Low

1060245

ZHX1
Zinc fingers and homeoboxes protein 1

1

0

High-throughput

0.265

Low

1060238

TMOD3
Tropomodulin-3

1

0

High-throughput

0.249

Low

330136

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

1060179

TCAL5
Transcription elongation factor A protein-like 5

1

0

High-throughput

0.232

Low

1060197

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025