HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: CHFR (Q96EP1)
E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196) (RING-type E3 ubiquitin transferase CHFR)
Gene: CHFR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	19182791
Identification Methods	affinity chromatography technology, enzymatic study, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 664
+	Hs
		1368049 HDAC2_HUMAN (1-478): 0: 666: 85.92		CHFR_HUMAN (1-664): 0: 900: 100.00
+	Hs
		765757 HDAC2_HUMAN (1-478): 0: 666: 85.92		BMI1_HUMAN (287-438): 6.69e-39: 148: 19.62
+	Hs
		1110049 HDAC1_HUMAN (1-482): 0: 668: 100.00		PCGF6_HUMAN (279-410): 8.06e-36: 140: 22.46
+	Hs
		1368098 HDAC2_HUMAN (1-478): 0: 666: 85.92		PCGF6_HUMAN (279-410): 8.06e-36: 140: 22.46
+	Hs
		1055800 HDAC1_HUMAN (1-482): 0: 668: 100.00		RING1_HUMAN (268-455): 1.82e-34: 137: 17.14
+	Hs
		1110019 HDAC1_HUMAN (1-482): 0: 668: 100.00		RING2_HUMAN (274-441): 3.04e-32: 129: 15.39
+	Hs
		1368077 HDAC2_HUMAN (1-478): 0: 666: 85.92		RING2_HUMAN (274-441): 3.04e-32: 129: 15.39
+	Mm
		1000037 HDAC2_MOUSE (1-478): 0: 664: 85.71		RING2_MOUSE (274-441): 3.01e-32: 129: 15.39