Protein: CHFR
E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196) (RING-type E3 ubiquitin transferase CHFR)

Gene: CHFR
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q96EP1

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

982280

UB2D2
Ubiquitin-conjugating enzyme E2 D2

7

20

Small-scale

0.964

High

906741

UB2D1
Ubiquitin-conjugating enzyme E2 D1

6

20

Small-scale

0.947

High

1389441

CHFR
E3 ubiquitin-protein ligase CHFR

4

19

Small-scale

0.882

High

1381180

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

20

High-throughput

0.861

High

1389445

UB2E2
Ubiquitin-conjugating enzyme E2 E2

3

20

High-throughput

0.861

High

957161

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

20

Small-scale

0.857

High

1331910

DTX3
Probable E3 ubiquitin-protein ligase DTX3

4

0

High-throughput

0.846

High

920181

PLK1
Serine/threonine-protein kinase PLK1

3

3

Small-scale

0.834

High

1127753

HLTF
Helicase-like transcription factor

2

11

Small-scale

0.819

High

957813

UBE2N
Ubiquitin-conjugating enzyme E2 N

2

20

Small-scale

0.800

High

170277

AURKA
Aurora kinase A

2

6

Small-scale

0.754

High

487631

PARP1
Poly [ADP-ribose] polymerase 1

7

14

Small-scale

0.743

High

909370

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

1383918

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1389442

RN125
E3 ubiquitin-protein ligase RNF125

1

16

High-throughput

0.698

High

1389452

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

1126597

GRB14
Growth factor receptor-bound protein 14

1

5

Small-scale

0.648

High

993706

UBC9
SUMO-conjugating enzyme UBC9

1

20

Small-scale

0.647

High

728379

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.618

High

1025497

CDK5
Cyclin-dependent kinase 5

1

6

Small-scale

0.618

High

1132627

KIF22
Kinesin-like protein KIF22

1

7

Small-scale

0.618

High

1389444

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

Small-scale

0.586

High

1371592

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

18

Small-scale

0.584

High

1102361

GRB10
Growth factor receptor-bound protein 10

1

3

Small-scale

0.579

High

1109984

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.578

High

1388692

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

Small-scale

0.578

High

903454

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

12

Small-scale

0.561

High

1086670

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

Small-scale

0.561

High

1368049

HDAC2
Histone deacetylase 2

1

8

Small-scale

0.561

High

1389443

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

2

Small-scale

0.561

High

688103

EF1G
Elongation factor 1-gamma

1

2

High-throughput

0.541

High

1389448

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

20

High-throughput

0.541

High

1389449

RBX2
RING-box protein 2

1

2

High-throughput

0.541

High

1389451

CBLC
E3 ubiquitin-protein ligase CBL-C

1

2

High-throughput

0.541

High

714344

PML
Protein PML

1

17

Small-scale

0.501

High

551195

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.479

High

790083

ZEB1
Zinc finger E-box-binding homeobox 1

1

12

Small-scale

0.479

High

888248

MCM2
DNA replication licensing factor MCM2

1

3

Small-scale

0.479

High

890559

RBP2
E3 SUMO-protein ligase RanBP2

1

5

Small-scale

0.479

High

1045630

TF65
Transcription factor p65

1

4

Small-scale

0.479

High

1086892

CDC20
Cell division cycle protein 20 homolog

1

10

Small-scale

0.479

High

1099754

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

Small-scale

0.479

High

1113962

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1292501

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

12

Small-scale

0.479

High

1389447

RN126
E3 ubiquitin-protein ligase RNF126

1

1

Small-scale

0.479

High

1389446

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

260286

BRD4
Bromodomain-containing protein 4

1

10

High-throughput

0.457

High

567463

TCTP
Translationally-controlled tumor protein

1

1

Small-scale

0.457

High

474891

VIME
Vimentin

1

13

Small-scale

0.437

High

1060904

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

1

Small-scale

0.437

High

323049

WDR47
WD repeat-containing protein 47

1

13

High-throughput

0.417

High

800417

ITAE
Integrin alpha-E

1

2

High-throughput

0.417

High

1389450

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

1

High-throughput

0.417

High

1227238

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.407

High

1280016

CE024
UPF0461 protein C5orf24

2

0

High-throughput

0.328

High


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Last updated: 11Aug2025