HitPredict

Interactor 1: MTMR1 (Q13613)
Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95)
Gene: MTMR1

Interactor 2: MTMR9 (Q96QG7)
Myotubularin-related protein 9 (Inactive phosphatidylinositol 3-phosphatase 9)
Gene: MTMR9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	GRAM~Myotub-related, Myotub-related~Myotub-related
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0046856 - phosphatidylinositol dephosphorylation GO:0060304 - regulation of phosphatidylinositol dephosphorylation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 665 Hs			1 549
+	Hs
		1112357 MTMR1_HUMAN (1-665): 0: 969: 100.00		MTMR2_HUMAN (5-539): 0: 714: 36.31
+	Hs
		1112416 MTMR2_HUMAN (33-665): 0: 890: 69.72		MTMR9_HUMAN (1-549): 0: 769: 100.00
+	Hs
		1112403 MTMR2_HUMAN (33-665): 0: 890: 69.72		MTMR2_HUMAN (5-539): 0: 714: 36.31
+	Hs
		1107649 MTMR2_HUMAN (33-665): 0: 890: 69.72		MTM1_HUMAN (13-533): 0: 678: 33.02
+	Hs
		1107648 MTM1_HUMAN (61-636): 0: 819: 59.76		MTM1_HUMAN (13-533): 0: 678: 33.02
+	Hs
		1388923 MTMR8_HUMAN (95-662): 0: 707: 36.24		MTMR9_HUMAN (1-549): 0: 769: 100.00
+	Hs
		1388921 MTMR8_HUMAN (95-662): 0: 707: 36.24		MTMR8_HUMAN (5-542): 0: 698: 34.06
+	Hs
		1112425 MTMR2_HUMAN (33-665): 0: 890: 69.72		MTMRA_HUMAN (25-546): 3.19e-156: 467: 22.11
+	Hs
		1112371 MTMR1_HUMAN (1-665): 0: 969: 100.00		MTMRD_HUMAN (129-497): 3.02e-110: 363: 23.68
+	Hs
		331750 MTMR1_HUMAN (1-665): 0: 969: 100.00		MTMR5_HUMAN (222-497): 9.67e-97: 324: 29.45
+	Hs
		1107674 MTM1_HUMAN (61-636): 0: 819: 59.76		MTMRA_HUMAN (25-546): 3.19e-156: 467: 22.11
+	Hs
		1112420 MTMR2_HUMAN (33-665): 0: 890: 69.72		MTMRC_HUMAN (25-480): 2.38e-124: 383: 22.69
+	Hs
		1112409 MTMR2_HUMAN (33-665): 0: 890: 69.72		MTMRD_HUMAN (129-497): 3.02e-110: 363: 23.68
+	Hs
		62292 MTMR2_HUMAN (33-665): 0: 890: 69.72		MTMRB_HUMAN (18-479): 2.43e-113: 354: 25.14
+	Hs
		331751 MTMR2_HUMAN (33-665): 0: 890: 69.72		MTMR5_HUMAN (222-497): 9.67e-97: 324: 29.45
+	Hs
		1107671 MTM1_HUMAN (61-636): 0: 819: 59.76		MTMRC_HUMAN (25-480): 2.38e-124: 383: 22.69
+	Hs
		62291 MTM1_HUMAN (61-636): 0: 819: 59.76		MTMRB_HUMAN (18-479): 2.43e-113: 354: 25.14
+	Dm
		1269063 Q9VMI9_DROME (101-656): 0: 742: 54.21		Q7KSP6_DROME (122-205): 8.42e-19: 92.8: 28.57