Protein: MTMR2
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 (EC 3.1.3.95) (Myotubularin-related protein 2) (Phosphatidylinositol-3-phosphate phosphatase)

Gene: MTMR2
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q13614

Gene Ontology (top 5):
GO:0002091 - negative regulation of receptor internalization
GO:0004438 - phosphatidylinositol-3-phosphate phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005774 - vacuolar membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

331751

MTMR5
Myotubularin-related protein 5

6

16

Small-scale

0.943

High

1112420

MTMRC
Myotubularin-related protein 12

5

18

Small-scale

0.924

High

1112357

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

5

19

High-throughput

0.922

High

1112425

MTMRA
Myotubularin-related protein 10

5

18

High-throughput

0.922

High

1112416

MTMR9
Myotubularin-related protein 9

4

18

High-throughput

0.892

High

1112409

MTMRD
Myotubularin-related protein 13

3

18

High-throughput

0.867

High

62292

MTMRB
Myotubularin-related protein 11

2

17

High-throughput

0.789

High

1112403

MTMR2
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2

2

18

Small-scale

0.754

High

257110

CCD22
Coiled-coil domain-containing protein 22

5

3

High-throughput

0.716

High

1107649

MTM1
Myotubularin

1

19

High-throughput

0.618

High

1091489

DLG1
Disks large homolog 1

2

5

High-throughput

0.584

High

1112421

SPCS
O-phosphoseryl-tRNA(Sec) selenium transferase

2

0

High-throughput

0.559

High

1034228

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

19

High-throughput

0.541

High

1112404

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

15

High-throughput

0.541

High

542769

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

1

High-throughput

0.536

High

626215

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

High-throughput

0.536

High

971496

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.536

High

1112405

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

2

High-throughput

0.536

High

1104781

SNTA1
Alpha-1-syntrophin

1

7

Small-scale

0.527

High

1112413

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.518

High

330445

LC7L3
Luc7-like protein 3

1

0

High-throughput

0.513

High

996687

TBA1B
Tubulin alpha-1B chain

1

0

High-throughput

0.513

High

451153

NFL
Neurofilament light polypeptide

1

3

Small-scale

0.506

High

641592

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

19

High-throughput

0.494

High

706120

S10A2
Protein S100-A2

1

6

High-throughput

0.489

High

167698

LIN7A
Protein lin-7 homolog A

1

6

High-throughput

0.479

High

168686

CSKP
Peripheral plasma membrane protein CASK

1

5

High-throughput

0.479

High

241618

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

272149

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

714098

PML
Protein PML

1

1

High-throughput

0.479

High

1016427

SRSF3
Serine/arginine-rich splicing factor 3

1

1

High-throughput

0.479

High

1045264

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1099066

SRSF5
Serine/arginine-rich splicing factor 5

1

1

High-throughput

0.479

High

1112406

SMU1
WD40 repeat-containing protein SMU1

1

3

High-throughput

0.479

High

1112408

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

1112412

BICD2
Protein bicaudal D homolog 2

1

4

High-throughput

0.479

High

1112415

NUD16
U8 snoRNA-decapping enzyme

1

1

High-throughput

0.479

High

1112417

EYA3
Protein phosphatase EYA3

1

1

High-throughput

0.479

High

1112424

LIN7C
Protein lin-7 homolog C

1

11

High-throughput

0.479

High

1112426

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

475352

RS17
Small ribosomal subunit protein eS17

1

0

High-throughput

0.458

High

686142

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.458

High

693727

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

859596

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.458

High

975678

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

1112410

AROS
Active regulator of SIRT1

1

0

High-throughput

0.458

High

1112414

RL3L
Ribosomal protein uL3-like

1

0

High-throughput

0.458

High

1112427

MRT4
mRNA turnover protein 4 homolog

1

0

High-throughput

0.458

High

1112422

CASS4
Cas scaffolding protein family member 4

1

1

High-throughput

0.457

High

1112423

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

516760

SCHI1
Schwannomin-interacting protein 1

1

1

High-throughput

0.445

High

65607

OTOL1
Otolin-1

1

1

High-throughput

0.437

High

105891

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

710230

EPHA2
Ephrin type-A receptor 2

1

4

High-throughput

0.437

High

1103506

MPP3
MAGUK p55 subfamily member 3

1

5

High-throughput

0.437

High

1112407

MPP7
MAGUK p55 subfamily member 7

1

5

High-throughput

0.437

High

1112411

G45IP
Large ribosomal subunit protein mL64

1

1

High-throughput

0.437

High

287291

RF1M
Peptide chain release factor 1, mitochondrial

1

0

High-throughput

0.279

Low

572358

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

0

High-throughput

0.279

Low

1031895

NC2B
Protein Dr1

1

0

High-throughput

0.279

Low

1112419

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.279

Low

1112418

EBP2
Probable rRNA-processing protein EBP2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025