HitPredict

Interactor 1: MTMR8 (Q96EF0)
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8 (EC 3.1.3.95) (Myotubularin-related protein 8) (Phosphatidylinositol-3-phosphate phosphatase)
Gene: MTMR8

Interactor 2: MTMR9 (Q96QG7)
Myotubularin-related protein 9 (Inactive phosphatidylinositol 3-phosphatase 9)
Gene: MTMR9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.977

Property	Details
Experiments	16189514, 27880917, 27432908, 25659891, 28514442, 29892012, 33961781, 22647598, 31515488, unassigned3799
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Myotub-related~Myotub-related
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010507 - negative regulation of autophagy GO:0032991 - protein-containing complex GO:0046856 - phosphatidylinositol dephosphorylation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 704 Hs			1 549
+	Hs
		1388921 MTMR8_HUMAN (1-704): 0: 1076: 100.00		MTMR8_HUMAN (5-542): 0: 698: 34.06
+	Hs
		1388925 MTMR8_HUMAN (1-704): 0: 1076: 100.00		MTMR7_HUMAN (5-519): 0: 658: 36.60
+	Hs
		1400893 MTMR6_HUMAN (1-543): 0: 744: 61.28		MTMR9_HUMAN (1-549): 0: 769: 100.00
+	Hs
		1400892 MTMR7_HUMAN (1-611): 0: 738: 54.72		MTMR9_HUMAN (1-549): 0: 769: 100.00
+	Hs
		1112416 MTMR2_HUMAN (2-541): 0: 732: 37.89		MTMR9_HUMAN (1-549): 0: 769: 100.00
+	Hs
		1112403 MTMR2_HUMAN (2-541): 0: 732: 37.89		MTMR2_HUMAN (5-539): 0: 714: 36.31
+	Hs
		1112357 MTMR2_HUMAN (2-541): 0: 732: 37.89		MTMR1_HUMAN (5-539): 0: 712: 35.53
+	Hs
		1490432 MTMR6_HUMAN (1-543): 0: 744: 61.28		MTMR6_HUMAN (5-543): 0: 685: 34.12
+	Hs
		1107649 MTMR2_HUMAN (2-541): 0: 732: 37.89		MTM1_HUMAN (13-533): 0: 678: 33.02
+	Hs
		1490429 MTMR6_HUMAN (1-543): 0: 744: 61.28		MTMR7_HUMAN (5-519): 0: 658: 36.60
+	Hs
		1490428 MTMR7_HUMAN (1-611): 0: 738: 54.72		MTMR7_HUMAN (5-519): 0: 658: 36.60
+	Hs
		1452436 MTMR7_HUMAN (1-611): 0: 738: 54.72		MTMR4_HUMAN (21-531): 0: 578: 28.47
+	Hs
		1112425 MTMR2_HUMAN (2-541): 0: 732: 37.89		MTMRA_HUMAN (25-546): 3.19e-156: 467: 22.11
+	Hs
		1112420 MTMR2_HUMAN (2-541): 0: 732: 37.89		MTMRC_HUMAN (25-480): 2.38e-124: 383: 22.69
+	Hs
		1112409 MTMR2_HUMAN (2-541): 0: 732: 37.89		MTMRD_HUMAN (129-497): 3.02e-110: 363: 23.68
+	Hs
		62292 MTMR2_HUMAN (2-541): 0: 732: 37.89		MTMRB_HUMAN (18-479): 2.43e-113: 354: 25.14
+	Hs
		331751 MTMR2_HUMAN (2-541): 0: 732: 37.89		MTMR5_HUMAN (222-497): 9.67e-97: 324: 29.45
+	Dm
		1344959 Q9W1Q6_DROME (1-572): 0: 736: 51.65		Q8SZY7_DROME (1-155): 5.64e-38: 149: 47.88