HitPredict

Interactor 1: NTRK1 (Q3UFB7)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1)
Gene: NTRK1

Interactor 2: SQSTM (Q64337)
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)
Gene: Sqstm1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	18598672, 21574998, 17389358
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005770 - late endosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 799 Mm			1 442
+	Rn
		139616 NTRK1_RAT (1-799): 0: 630: 96.25		SQSTM_RAT (1-442): 0: 762: 97.06
+	Hs
		384793 NTRK1_HUMAN (1-799): 0: 608: 86.23		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Mm
		546304 NTRK2_MOUSE (12-799): 8.94e-166: 502: 47.02		SQSTM_MOUSE (1-442): 0: 777: 100.00
+	Hs
		1036607 NTRK3_HUMAN (25-799): 1.94e-177: 532: 47.04		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		609276 FGFR3_HUMAN (128-799): 1.34e-175: 526: 25.42		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1036611 NTRK2_HUMAN (12-799): 3.62e-170: 513: 45.69		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		729651 VGFR2_HUMAN (196-790): 2.24e-121: 398: 23.86		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		411378 INSR_HUMAN (496-780): 4.49e-68: 247: 42.28		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		385120 NTRK1_HUMAN (1-799): 0: 608: 86.23		MIB1_HUMAN (105-228): 1.65e-27: 117: 27.69
+	Hs
		434233 RET_HUMAN (265-797): 2.04e-116: 380: 24.46		MIB1_HUMAN (105-228): 1.65e-27: 117: 27.69
+	Hs
		319859 DDR2_HUMAN (502-784): 3.64e-73: 257: 45.22		HERC2_HUMAN (120-197): 1.35e-11: 69: 32.50