HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: SF3B3 (Q15393)
Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130)
Gene: SF3B3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	21145461, 23951410
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~MMS1_N, CPSF_A~Cullin
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 1217
+	Hs
		1112498 CUL1_HUMAN (6-745): 0: 770: 36.24		SF3B3_HUMAN (1-1217): 0: 1474: 100.00
+	Hs
		1114837 CUL4A_HUMAN (4-745): 0: 770: 26.86		SF3B3_HUMAN (1-1217): 0: 1474: 100.00
+	Hs
		1113171 CUL3_HUMAN (1-745): 0: 763: 26.38		SF3B3_HUMAN (1-1217): 0: 1474: 100.00
+	Mm
		1189314 CUL4A_MOUSE (4-745): 0: 771: 26.73		DDB1_MOUSE (2-1211): 0: 1062: 21.02
+	Hs
		1112511 CUL1_HUMAN (6-745): 0: 770: 36.24		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Hs
		1114848 CUL4A_HUMAN (4-745): 0: 770: 26.86		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Hs
		1115215 CUL4B_HUMAN (4-745): 0: 767: 27.79		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Mm
		58993 CUL4B_MOUSE (4-745): 0: 767: 27.79		DDB1_MOUSE (2-1211): 0: 1062: 21.02
+	Hs
		1113209 CUL3_HUMAN (1-745): 0: 763: 26.38		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	At
		1320290 CUL4_ARATH (4-745): 0: 719: 26.60		DDB1A_ARATH (2-1211): 0: 1039: 20.03
+	At
		235873 CUL4_ARATH (4-745): 0: 719: 26.60		DDB1B_ARATH (1-1211): 0: 1032: 20.10
+	Hs
		1157846 CUL5_HUMAN (7-745): 0: 628: 26.69		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Dm
		1203001 Q5BI50_DROME (4-745): 0: 741: 27.06		DDB1_DROME (2-1211): 0: 948: 19.94
+	Ce
		1164817 CUL4_CAEEL (14-745): 0: 570: 22.09		DDB1_CAEEL (3-1211): 0: 832: 18.50
+	Hs
		1083354 CUL4A_HUMAN (4-745): 0: 770: 26.86		CPSF1_HUMAN (701-1216): 4.43e-121: 410: 15.99
+	Hs
		1083353 CUL3_HUMAN (1-745): 0: 763: 26.38		CPSF1_HUMAN (701-1216): 4.43e-121: 410: 15.99