Interactor 1: NLRC4 (Q3UP24)
NLR family CARD domain-containing protein 4 (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)
Gene: NLRC4

Interactor 2: BIR1E (Q9R016)
Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5)
Gene: Naip5

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.852

The method score is based on:

Property Details
Experiments 23765277, 26449474, 29146805
Identification Methods molecular sieving, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains BIR~NACHT, NACHT~NACHT, NACHT~NLRC4_HD, NACHT~NOD2_WH, NLRC4_HD~NOD2_WH
Common GO terms GO:0005524 - ATP binding
GO:0006915 - apoptotic process
GO:0006954 - inflammatory response
GO:0016045 - detection of bacterium
GO:0032731 - positive regulation of interleukin-1 beta production
and 4 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024