HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: GCN1 (Q92616)
Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1)
Gene: GCN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35563538, 37788672
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 2671
+	Hs
		285910 CUL3_HUMAN (1-768): 0: 943: 100.00		SF3B1_HUMAN (1328-2115): 6.76e-60: 230: 14.22
+	Hs
		1113908 CUL3_HUMAN (1-768): 0: 943: 100.00		TNPO1_HUMAN (908-1705): 1.7e-51: 201: 13.59
+	Hs
		134028 CUL3_HUMAN (1-768): 0: 943: 100.00		IPO5_HUMAN (1381-2409): 4.61e-37: 155: 12.18
+	Dm
		1304391 Q8IP45_DROME (17-768): 0: 857: 69.08		CAND1_DROME (1333-2593): 1.84e-54: 212: 13.27
+	Hs
		1113580 CUL3_HUMAN (1-768): 0: 943: 100.00		CAND1_HUMAN (1460-2587): 2.11e-22: 108: 13.92
+	Hs
		717804 CUL3_HUMAN (1-768): 0: 943: 100.00		2AAA_HUMAN (959-1405): 1.35e-19: 97.8: 12.22
+	Hs
		1113356 CUL3_HUMAN (1-768): 0: 943: 100.00		ECM29_HUMAN (1769-2544): 4.54e-09: 64.6: 12.24
+	Hs
		839266 CUL4A_HUMAN (10-768): 0: 801: 38.32		MTOR_HUMAN (824-2632): 3.33e-34: 147: 12.46
+	Hs
		285909 CUL1_HUMAN (18-768): 0: 709: 30.57		SF3B1_HUMAN (1328-2115): 6.76e-60: 230: 14.22
+	Hs
		1114920 CUL4A_HUMAN (10-768): 0: 801: 38.32		CAND1_HUMAN (1460-2587): 2.11e-22: 108: 13.92
+	Hs
		1115282 CUL4B_HUMAN (5-768): 0: 796: 36.77		CAND1_HUMAN (1460-2587): 2.11e-22: 108: 13.92
+	Hs
		717805 CUL4A_HUMAN (10-768): 0: 801: 38.32		2AAA_HUMAN (959-1405): 1.35e-19: 97.8: 12.22
+	Dm
		1173428 CUL1_DROME (29-768): 0: 671: 27.49		CAND1_DROME (1333-2593): 1.84e-54: 212: 13.27
+	Hs
		1114804 CUL4A_HUMAN (10-768): 0: 801: 38.32		CKAP5_HUMAN (1043-1968): 1.06e-09: 66.6: 10.88
+	Hs
		1114885 CUL4A_HUMAN (10-768): 0: 801: 38.32		ECM29_HUMAN (1769-2544): 4.54e-09: 64.6: 12.24
+	Hs
		1112580 CUL1_HUMAN (18-768): 0: 709: 30.57		CAND1_HUMAN (1460-2587): 2.11e-22: 108: 13.92
+	Mm
		1253432 CUL1_MOUSE (17-768): 0: 710: 30.53		CAND1_MOUSE (1460-2587): 3.04e-22: 107: 13.61
+	Hs
		1112901 CUL2_HUMAN (30-768): 0: 673: 26.17		CAND1_HUMAN (1460-2587): 2.11e-22: 108: 13.92
+	Hs
		1291113 CUL5_HUMAN (25-768): 0: 597: 23.77		CAND1_HUMAN (1460-2587): 2.11e-22: 108: 13.92