Protein: PSMD6
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)

Gene: PSMD6
Organism: Homo sapiens
Interactions: 231
UniProt ID: Q15008

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005576 - extracellular region
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005838 - proteasome regulatory particle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

130893

PSDE
26S proteasome non-ATPase regulatory subunit 14

9

20

Small-scale

0.972

High

849202

PSMD7
26S proteasome non-ATPase regulatory subunit 7

7

20

High-throughput

0.967

High

198630

PSMD3
26S proteasome non-ATPase regulatory subunit 3

7

16

Small-scale

0.967

High

572957

PRS6A
26S proteasome regulatory subunit 6A

6

20

Small-scale

0.949

High

906832

PRS4
26S proteasome regulatory subunit 4

5

20

Small-scale

0.930

High

121764

PSD11
26S proteasome non-ATPase regulatory subunit 11

5

18

High-throughput

0.929

High

122017

PSD12
26S proteasome non-ATPase regulatory subunit 12

4

20

High-throughput

0.906

High

907033

PRS8
26S proteasome regulatory subunit 8

4

20

High-throughput

0.906

High

1062898

PSD13
26S proteasome non-ATPase regulatory subunit 13

4

20

High-throughput

0.903

High

798666

PRS6B
26S proteasome regulatory subunit 6B

4

20

Small-scale

0.900

High

893553

SEM1
26S proteasome complex subunit SEM1

4

1

Small-scale

0.887

High

730263

PRS7
26S proteasome regulatory subunit 7

3

20

Small-scale

0.855

High

913268

PRS10
26S proteasome regulatory subunit 10B

3

20

Small-scale

0.855

High

1062891

UBQL2
Ubiquilin-2

3

15

High-throughput

0.847

High

227483

PRKN
E3 ubiquitin-protein ligase parkin

3

12

Small-scale

0.827

High

872268

RD23B
UV excision repair protein RAD23 homolog B

3

20

Small-scale

0.827

High

1062897

UBQL1
Ubiquilin-1

2

18

High-throughput

0.815

High

1062850

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

2

5

Small-scale

0.789

High

1062909

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

8

7

Small-scale

0.751

High

1062809

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

17

High-throughput

0.724

High

874099

PSMD4
26S proteasome non-ATPase regulatory subunit 4

5

4

Small-scale

0.716

High

1027653

PSMD2
26S proteasome non-ATPase regulatory subunit 2

4

17

High-throughput

0.706

High

831993

PSB3
Proteasome subunit beta type-3

4

20

High-throughput

0.699

High

276182

PSD10
26S proteasome non-ATPase regulatory subunit 10

4

4

Small-scale

0.694

High

1062814

ADRM1
Proteasomal ubiquitin receptor ADRM1

4

3

High-throughput

0.694

High

923997

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

10

High-throughput

0.691

High

1062864

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.691

High

983128

UBE3A
Ubiquitin-protein ligase E3A

4

9

Small-scale

0.676

High

656116

PSB9
Proteasome subunit beta type-9

3

20

High-throughput

0.667

High

1062821

CCD92
Coiled-coil domain-containing protein 92

3

1

High-throughput

0.667

High

1062849

ZFN2B
AN1-type zinc finger protein 2B

3

5

High-throughput

0.667

High

1062861

PSB7
Proteasome subunit beta type-7

3

20

High-throughput

0.667

High

819804

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

3

High-throughput

0.665

High

637690

PSA2
Proteasome subunit alpha type-2

3

20

Small-scale

0.662

High

870808

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

3

4

High-throughput

0.662

High

1062815

PSMD5
26S proteasome non-ATPase regulatory subunit 5

3

2

Small-scale

0.662

High

637422

PSA1
Proteasome subunit alpha type-1

3

20

High-throughput

0.656

High

893673

PSA6
Proteasome subunit alpha type-6

3

20

Small-scale

0.656

High

475779

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

16

High-throughput

0.647

High

504104

HSP7C
Heat shock cognate 71 kDa protein

3

2

High-throughput

0.633

High

122191

PSMD9
26S proteasome non-ATPase regulatory subunit 9

2

3

High-throughput

0.628

High

1062824

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

5

High-throughput

0.624

High

656717

PSB5
Proteasome subunit beta type-5

2

20

High-throughput

0.621

High

1062862

PSMD1
26S proteasome non-ATPase regulatory subunit 1

2

17

High-throughput

0.621

High

1062867

PAAF1
Proteasomal ATPase-associated factor 1

2

7

High-throughput

0.621

High

397972

ISG15
Ubiquitin-like protein ISG15

1

15

Small-scale

0.618

High

872158

RD23A
UV excision repair protein RAD23 homolog A

1

18

Small-scale

0.618

High

1062819

MIDN
Midnolin

1

1

High-throughput

0.618

High

1062825

DDI2
Protein DDI1 homolog 2

1

18

High-throughput

0.618

High

1062884

UBQL4
Ubiquilin-4

1

20

Small-scale

0.618

High

570536

PTN2
Tyrosine-protein phosphatase non-receptor type 2

2

6

High-throughput

0.611

High

637886

PSA3
Proteasome subunit alpha type-3

2

20

High-throughput

0.611

High

986798

PSME1
Proteasome activator complex subunit 1

2

1

Small-scale

0.611

High

1062812

UBE3C
Ubiquitin-protein ligase E3C

2

11

Small-scale

0.611

High

1062894

PSME2
Proteasome activator complex subunit 2

2

1

Small-scale

0.611

High

1062905

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

6

Small-scale

0.611

High

1062860

CC74B
Coiled-coil domain-containing protein 74B

3

3

High-throughput

0.609

High

832104

PSB2
Proteasome subunit beta type-2

2

20

Small-scale

0.601

High

874944

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.586

High

300311

DKK1
Dickkopf-related protein 1

2

0

High-throughput

0.585

High

1062906

TRAF6
TNF receptor-associated factor 6

2

5

High-throughput

0.584

High

92622

E9PMD8
Proteasome 26S subunit, ATPase 3

1

20

High-throughput

0.575

High

359954

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

1

High-throughput

0.571

High

1062881

GORS2
Golgi reassembly-stacking protein 2

2

1

High-throughput

0.553

High

1062848

DDI1
Protein DDI1 homolog 1

1

14

High-throughput

0.553

High

1062885

ATD3A
ATPase family AAA domain-containing protein 3A

1

9

High-throughput

0.553

High

156291

PSA7
Proteasome subunit alpha type-7

1

20

High-throughput

0.536

High

236930

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

2

High-throughput

0.536

High

270414

KS6A5
Ribosomal protein S6 kinase alpha-5

1

3

High-throughput

0.536

High

314759

PSMG1
Proteasome assembly chaperone 1

1

1

High-throughput

0.536

High

594531

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.536

High

638133

PSA4
Proteasome subunit alpha type-4

1

20

High-throughput

0.536

High

656232

PSA5
Proteasome subunit alpha type-5

1

20

High-throughput

0.536

High

656601

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.536

High

1061377

PSME4
Proteasome activator complex subunit 4

1

1

High-throughput

0.536

High

1062345

CND2
Condensin complex subunit 2

1

2

High-throughput

0.536

High

1062816

MK06
Mitogen-activated protein kinase 6

1

6

High-throughput

0.536

High

1062826

ECM29
Proteasome adapter and scaffold protein ECM29

1

3

High-throughput

0.536

High

1062843

ZFN2A
AN1-type zinc finger protein 2A

1

5

High-throughput

0.536

High

1062863

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.536

High

1062865

SOSB1
SOSS complex subunit B1

1

1

High-throughput

0.536

High

1062866

SLX1
Structure-specific endonuclease subunit SLX1

1

1

High-throughput

0.536

High

1062876

DUS15
Dual specificity protein phosphatase 15

1

1

High-throughput

0.536

High

1062893

AMFR
E3 ubiquitin-protein ligase AMFR

1

2

High-throughput

0.536

High

1062903

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

1

High-throughput

0.536

High

1062911

STK24
Serine/threonine-protein kinase 24

1

4

High-throughput

0.536

High

1062901

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

11

High-throughput

0.515

High

175388

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.513

High

523765

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.513

High

776324

MLH1
DNA mismatch repair protein Mlh1

1

0

High-throughput

0.513

High

791568

HD
Huntingtin

1

0

High-throughput

0.513

High

1047933

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

0

High-throughput

0.513

High

1062813

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

1062851

PSMF1
Proteasome inhibitor PI31 subunit

1

0

High-throughput

0.513

High

1062857

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

0

High-throughput

0.513

High

1062872

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

1062886

ARHGC
Rho guanine nucleotide exchange factor 12

1

0

High-throughput

0.513

High

1062900

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.513

High

1062907

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

316889

KLF8
Krueppel-like factor 8

1

6

High-throughput

0.500

High

1062908

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.493

High

64306

AN36A
Ankyrin repeat domain-containing protein 36A

1

2

High-throughput

0.489

High

380298

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.489

High

452780

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

622676

ERD21
ER lumen protein-retaining receptor 1

1

1

High-throughput

0.489

High

1062811

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

1062823

TMM31
Transmembrane protein 31

1

1

High-throughput

0.489

High

1062837

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.489

High

1062854

CC74A
Coiled-coil domain-containing protein 74A

1

3

High-throughput

0.489

High

1062880

ANKZ1
tRNA endonuclease ANKZF1

1

1

High-throughput

0.489

High

117005

SGK1
Serine/threonine-protein kinase Sgk1

1

3

High-throughput

0.479

High

255793

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

294841

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

295805

ST17B
Serine/threonine-protein kinase 17B

1

2

High-throughput

0.479

High

298525

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

304831

MFN2
Mitofusin-2

1

1

High-throughput

0.479

High

322648

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

326645

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.479

High

329727

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

386752

P53
Cellular tumor antigen p53

1

3

Small-scale

0.479

High

388452

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.479

High

487444

ANDR
Androgen receptor

1

8

High-throughput

0.479

High

488719

ARAF
Serine/threonine-protein kinase A-Raf

1

1

High-throughput

0.479

High

552754

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

569743

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

651234

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

656465

PSB4
Proteasome subunit beta type-4

1

20

High-throughput

0.479

High

684732

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

718504

NOS2
Nitric oxide synthase, inducible

1

1

High-throughput

0.479

High

720495

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

741870

TAGL2
Transgelin-2

1

1

High-throughput

0.479

High

749509

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

779432

CCNF
Cyclin-F

1

9

High-throughput

0.479

High

807728

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

808620

YAP1
Transcriptional coactivator YAP1

1

6

High-throughput

0.479

High

868188

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

896092

UBC12
NEDD8-conjugating enzyme Ubc12

1

4

High-throughput

0.479

High

898321

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

908561

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

940916

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

943791

CCNA1
Cyclin-A1

1

5

High-throughput

0.479

High

998723

EP300
Histone acetyltransferase p300

1

7

High-throughput

0.479

High

1018961

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

1035752

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1041600

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1050195

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.479

High

1052977

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

5

Small-scale

0.479

High

1054320

RBM39
RNA-binding protein 39

1

2

High-throughput

0.479

High

1061402

CUL7
Cullin-7

1

3

High-throughput

0.479

High

1062817

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1062818

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

1062820

AKIR2
Akirin-2

1

1

Small-scale

0.479

High

1062828

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1062832

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.479

High

1062834

SEML
Putative protein SEM1, isoform 2

1

1

High-throughput

0.479

High

1062838

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.479

High

1062839

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.479

High

1062840

TAXB1
Tax1-binding protein 1

1

1

High-throughput

0.479

High

1062846

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

1062852

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

1062853

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

1062859

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

1

Small-scale

0.479

High

1062870

CP250
Centrosome-associated protein CEP250

1

1

High-throughput

0.479

High

1062874

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

6

Small-scale

0.479

High

1062877

VP33B
Vacuolar protein sorting-associated protein 33B

1

3

High-throughput

0.479

High

1062879

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1062883

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1062887

PD1L1
Programmed cell death 1 ligand 1

1

2

High-throughput

0.479

High

1062888

HDAC6
Histone deacetylase 6

1

3

High-throughput

0.479

High

1062890

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1062892

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.479

High

1062895

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

High-throughput

0.479

High

1062896

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

1062899

HDAC5
Histone deacetylase 5

1

3

High-throughput

0.479

High

1062904

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

2

High-throughput

0.479

High

202639

TXNL1
Thioredoxin-like protein 1

1

0

High-throughput

0.458

High

323764

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

617554

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

678622

METK2
S-adenosylmethionine synthase isoform type-2

1

0

High-throughput

0.458

High

724437

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

0

Small-scale

0.458

High

830282

CASP4
Caspase-4

1

0

High-throughput

0.458

High

847804

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

944613

ELF3
ETS-related transcription factor Elf-3

1

0

High-throughput

0.458

High

1062830

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.458

High

1062831

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.458

High

1062841

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

1062855

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1062868

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

Small-scale

0.458

High

1062875

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1062882

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.458

High

1062871

KLF16
Krueppel-like factor 16

1

6

High-throughput

0.457

High

706

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

17

High-throughput

0.445

High

108945

H0YKT8
Proteasome subunit beta

1

20

High-throughput

0.445

High

170657

AXIN1
Axin-1

1

2

Small-scale

0.445

High

402026

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

497037

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

529134

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

1062810

ABRX2
BRISC complex subunit Abraxas 2

1

2

Small-scale

0.445

High

1062829

PKHA7
Pleckstrin homology domain-containing family A member 7

1

9

High-throughput

0.445

High

1062873

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

100776

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

239581

EIF1B
Eukaryotic translation initiation factor 1b

1

2

High-throughput

0.437

High

265136

MAF
Transcription factor Maf

1

3

Small-scale

0.437

High

354450

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.437

High

384862

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

488226

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.437

High

1044339

PTC1
Protein patched homolog 1

1

1

Small-scale

0.437

High

1053562

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

1062822

EMC4
ER membrane protein complex subunit 4

1

1

High-throughput

0.437

High

1062833

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.437

High

1062835

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.437

High

1062836

MEPCE
7SK snRNA methylphosphate capping enzyme

1

2

High-throughput

0.437

High

1062842

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.437

High

1062847

FBX25
F-box only protein 25

1

2

High-throughput

0.437

High

1062858

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.437

High

1062878

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1062889

ST17A
Serine/threonine-protein kinase 17A

1

2

High-throughput

0.437

High

1062902

RNF11
RING finger protein 11

1

4

Small-scale

0.437

High

831338

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

1062844

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.407

High

1062856

CKLF7
CKLF-like MARVEL transmembrane domain-containing protein 7

2

0

High-throughput

0.316

High

1062827

C102B
Coiled-coil domain-containing protein 102B

1

0

High-throughput

0.279

Low

1062845

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.279

Low

1062869

PSMG3
Proteasome assembly chaperone 3

1

0

High-throughput

0.279

Low

1062910

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

High-throughput

0.279

Low

283144

ZFAN5
AN1-type zinc finger protein 5

1

0

Small-scale

0.269

Low

329158

F107A
Actin-associated protein FAM107A

1

0

Small-scale

0.251

Low

489052

H14
Histone H1.4

1

0

High-throughput

0.249

Low

671069

ATPD
ATP synthase subunit delta, mitochondrial

1

0

High-throughput

0.249

Low

883824

TMM33
Transmembrane protein 33

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024