HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: CAND1 (Q86VP6)
Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)
Gene: CAND1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 27542266, 28715492, 29103612, 29499133, 12609982, 18173839, 36423380, 28524877, 37837399, 17439941, 16036220, 12706828, 21778237, 21249194, 22405651, 12504026, 16861300, 12684064, 21169563, 22767593 and 12 others

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Identification Methods affinity chromatography technology, pull down, cross-linking study, anti tag coimmunoprecipitation, tandem affinity purification, coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cullin~HEAT_EZ, Cullin~TIP120
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016567 - protein ubiquitination
and 1 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 776
Hs

1 1230
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Service provided by Combinatics, Japan

Last updated: 11Aug2025