HitPredict

Interactor 1: CAND1 (G5ED41)
Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1)
Gene: cand-1

Interactor 2: CUL2 (Q17390)
Cullin-2 (CUL-2)
Gene: cul-2

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.800

Property	Details
Experiments	20659444, 17609115
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cullin~TIP120
Common GO terms	GO:0005634 - nucleus GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1274 Ce			1 791
+	Hs
		1112580 CAND1_HUMAN (2-1263): 0: 768: 36.00		CUL1_HUMAN (24-791): 0: 756: 31.80
+	Hs
		1112901 CAND1_HUMAN (2-1263): 0: 768: 36.00		CUL2_HUMAN (19-791): 0: 755: 42.78
+	Hs
		1115282 CAND1_HUMAN (2-1263): 0: 768: 36.00		CUL4B_HUMAN (2-791): 0: 754: 24.72
+	Mm
		1253432 CAND1_MOUSE (2-1263): 0: 764: 35.84		CUL1_MOUSE (24-791): 0: 756: 31.80
+	Hs
		1114920 CAND1_HUMAN (2-1263): 0: 768: 36.00		CUL4A_HUMAN (18-791): 0: 745: 23.92
+	Hs
		1113580 CAND1_HUMAN (2-1263): 0: 768: 36.00		CUL3_HUMAN (2-791): 0: 734: 24.06
+	Mm
		1253452 CAND2_MOUSE (3-1269): 0: 728: 32.53		CUL1_MOUSE (24-791): 0: 756: 31.80
+	Hs
		273188 CAND2_HUMAN (2-1269): 0: 720: 32.89		CUL1_HUMAN (24-791): 0: 756: 31.80
+	Hs
		273190 CAND2_HUMAN (2-1269): 0: 720: 32.89		CUL4B_HUMAN (2-791): 0: 754: 24.72
+	Ce
		111411 CAND1_CAEEL (1-1274): 0: 759: 100.00		CUL1_CAEEL (18-791): 0: 708: 27.49
+	Hs
		273189 CAND2_HUMAN (2-1269): 0: 720: 32.89		CUL3_HUMAN (2-791): 0: 734: 24.06
+	Ce
		111413 CAND1_CAEEL (1-1274): 0: 759: 100.00		CUL3_CAEEL (13-791): 0: 657: 23.76
+	Dm
		1304391 CAND1_DROME (4-1266): 0: 679: 34.93		Q8IP45_DROME (1-791): 0: 721: 24.19
+	Dm
		1173428 CAND1_DROME (4-1266): 0: 679: 34.93		CUL1_DROME (24-791): 0: 706: 30.01
+	Ce
		111415 CAND1_CAEEL (1-1274): 0: 759: 100.00		CUL6_CAEEL (26-791): 0: 625: 26.77
+	Hs
		1291113 CAND1_HUMAN (2-1263): 0: 768: 36.00		CUL5_HUMAN (25-791): 0: 604: 24.75
+	At
		1318213 CAND1_ARATH (1-1260): 0: 657: 29.67		CUL4_ARATH (3-791): 0: 697: 24.53
+	At
		1318216 CAND1_ARATH (1-1260): 0: 657: 29.67		CUL1_ARATH (21-791): 0: 694: 24.16
+	Ce
		111416 CAND1_CAEEL (1-1274): 0: 759: 100.00		CUL5_CAEEL (26-791): 0: 581: 24.60
+	Sp
		151356 CAND1_SCHPO (4-1263): 9.16e-112: 381: 19.20		CUL1_SCHPO (24-791): 0: 689: 30.15