HitPredict

Interactor 1: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Interactor 2: DDX1 (Q92499)
ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB)
Gene: DDX1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	36950384
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:1990904 - ribonucleoprotein complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 763 Hs			1 740
+	Hs
		692104 MARK3_HUMAN (105-757): 1.34e-122: 386: 17.44		DDX1_HUMAN (1-740): 0: 571: 100.00
+	Hs
		1363285 DYRK2_HUMAN (46-549): 2.32e-120: 376: 33.53		DDX1_HUMAN (1-740): 0: 571: 100.00
+	Hs
		667954 CDK2_HUMAN (156-421): 2.08e-118: 360: 26.76		DDX1_HUMAN (1-740): 0: 571: 100.00
+	Hs
		141475 DYR1A_HUMAN (1-763): 0: 620: 100.00		DDX3X_HUMAN (1-380): 1.78e-41: 163: 13.47
+	Hs
		193105 DYR1A_HUMAN (1-763): 0: 620: 100.00		DDX3Y_HUMAN (1-380): 7e-41: 161: 13.97
+	Hs
		1115873 DYR1A_HUMAN (1-763): 0: 620: 100.00		DDX17_HUMAN (1-381): 6.43e-36: 147: 11.71
+	Hs
		608591 DYR1A_HUMAN (1-763): 0: 620: 100.00		DDX5_HUMAN (1-381): 9.96e-35: 142: 11.45
+	Hs
		807410 DYR1A_HUMAN (1-763): 0: 620: 100.00		IF4A3_HUMAN (3-72): 3.94e-11: 67.8: 30.00
+	Hs
		141327 CDK2_HUMAN (156-421): 2.08e-118: 360: 26.76		DDX3X_HUMAN (1-380): 1.78e-41: 163: 13.47
+	Hs
		608679 DYRK2_HUMAN (46-549): 2.32e-120: 376: 33.53		DDX5_HUMAN (1-381): 9.96e-35: 142: 11.45
+	Hs
		608465 AKT1_HUMAN (38-466): 1.32e-119: 369: 19.42		DDX5_HUMAN (1-381): 9.96e-35: 142: 11.45
+	At
		1182962 KSG7_ARATH (127-524): 8.35e-120: 366: 25.78		RH14_ARATH (3-380): 1.05e-34: 142: 14.76
+	Hs
		667960 CDK2_HUMAN (156-421): 2.08e-118: 360: 26.76		DDX17_HUMAN (1-381): 6.43e-36: 147: 11.71
+	Hs
		608456 CDK2_HUMAN (156-421): 2.08e-118: 360: 26.76		DDX5_HUMAN (1-381): 9.96e-35: 142: 11.45
+	At
		663854 CDKA1_ARATH (156-482): 1.21e-122: 371: 26.65		IF4A1_ARATH (2-103): 7.99e-18: 88.4: 20.59
+	Hs
		667599 CDK2_HUMAN (156-421): 2.08e-118: 360: 26.76		IF4A3_HUMAN (3-72): 3.94e-11: 67.8: 30.00
+	Zm
		21045 A0AAJ8WYD0_MAIZE (156-483): 1.97e-118: 359: 25.37		A0A1D6HQ89_MAIZE (1-71): 3e-11: 68.2: 29.58