Protein: DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)

Gene: DYRK2
Organism: Homo sapiens
Interactions: 168
UniProt ID: Q92630

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1157839

DDB1
DNA damage-binding protein 1

3

7

Small-scale

0.875

High

1366134

DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4

1

17

High-throughput

0.780

High

461774

HS90A
Heat shock protein HSP 90-alpha

2

20

Small-scale

0.754

High

1206949

CEP78
Centrosomal protein of 78 kDa

2

3

Small-scale

0.754

High

1104624

IKZF1
DNA-binding protein Ikaros

1

4

High-throughput

0.740

High

1366149

DCAF1
DDB1- and CUL4-associated factor 1

5

14

Small-scale

0.720

High

1366133

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

12

High-throughput

0.715

High

1209461

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

High-throughput

0.692

High

48039

RBM47
RNA-binding protein 47

1

11

High-throughput

0.691

High

63000

POTEF
POTE ankyrin domain family member F

1

10

High-throughput

0.691

High

225318

HTSF1
17S U2 SnRNP complex component HTATSF1

1

20

High-throughput

0.691

High

251634

CCNT1
Cyclin-T1

1

20

High-throughput

0.691

High

284193

SRS10
Serine/arginine-rich splicing factor 10

1

20

High-throughput

0.691

High

531119

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

8

High-throughput

0.691

High

724700

MK04
Mitogen-activated protein kinase 4

1

19

High-throughput

0.691

High

889628

CLK2
Dual specificity protein kinase CLK2

1

17

High-throughput

0.691

High

911646

NCBP2
Nuclear cap-binding protein subunit 2

1

20

High-throughput

0.691

High

1006603

SRPK2
SRSF protein kinase 2

1

19

High-throughput

0.691

High

1083410

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

7

High-throughput

0.691

High

1111823

TRA2A
Transformer-2 protein homolog alpha

1

20

High-throughput

0.691

High

1115866

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

18

High-throughput

0.691

High

1194253

LARP7
La-related protein 7

1

20

High-throughput

0.691

High

1361881

TITIN
Titin

1

9

High-throughput

0.691

High

1366143

G3BP2
Ras GTPase-activating protein-binding protein 2

1

11

High-throughput

0.691

High

1366144

SET1B
Histone-lysine N-methyltransferase SETD1B

1

9

High-throughput

0.691

High

325958

UBR5
E3 ubiquitin-protein ligase UBR5

3

17

Small-scale

0.678

High

274213

ANR17
Ankyrin repeat domain-containing protein 17

1

4

High-throughput

0.618

High

284759

RMXL2
RNA-binding motif protein, X-linked-like-2

1

20

Small-scale

0.618

High

295218

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

18

High-throughput

0.618

High

302595

RNF8
E3 ubiquitin-protein ligase RNF8

1

9

Small-scale

0.618

High

468658

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

613119

EGR1
Early growth response protein 1

1

5

High-throughput

0.618

High

710403

EPHA2
Ephrin type-A receptor 2

1

10

High-throughput

0.618

High

891709

GSK3B
Glycogen synthase kinase-3 beta

1

19

Small-scale

0.618

High

1047674

NOTC2
Neurogenic locus notch homolog protein 2

1

6

High-throughput

0.618

High

1093152

STK4
Serine/threonine-protein kinase 4

1

20

High-throughput

0.618

High

1104854

SNTB2
Beta-2-syntrophin

1

2

High-throughput

0.618

High

1272856

TAOK1
Serine/threonine-protein kinase TAO1

1

10

High-throughput

0.618

High

1366120

RBM14
RNA-binding protein 14

1

20

High-throughput

0.618

High

1366128

TARA
TRIO and F-actin-binding protein

1

20

Small-scale

0.618

High

1366141

TBK1
Serine/threonine-protein kinase TBK1

1

19

Small-scale

0.618

High

1366118

DCAF5
DDB1- and CUL4-associated factor 5

2

18

Small-scale

0.611

High

1366132

XPP3
Xaa-Pro aminopeptidase 3

2

1

Small-scale

0.611

High

422756

A4
Amyloid-beta precursor protein

2

9

High-throughput

0.602

High

643532

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

2

3

Small-scale

0.584

High

211582

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

8

Small-scale

0.578

High

214601

WDR62
WD repeat-containing protein 62

1

13

High-throughput

0.573

High

659273

SP100
Nuclear autoantigen Sp-100

1

16

High-throughput

0.573

High

1366115

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

5

High-throughput

0.573

High

1366123

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.573

High

282478

KTNA1
Katanin p60 ATPase-containing subunit A1

1

13

Small-scale

0.561

High

282947

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

17

Small-scale

0.561

High

1028313

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.561

High

1366111

FBXW7
F-box/WD repeat-containing protein 7

1

19

Small-scale

0.561

High

1143451

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.554

High

1245680

LARP1
La-related protein 1

1

20

High-throughput

0.554

High

1366109

KIFA3
Kinesin-associated protein 3

1

18

High-throughput

0.554

High

1366127

NDEL1
Nuclear distribution protein nudE-like 1

1

20

High-throughput

0.554

High

1366137

BCLF1
Bcl-2-associated transcription factor 1

1

18

High-throughput

0.554

High

1366145

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.554

High

1366148

KIF3A
Kinesin-like protein KIF3A

1

8

High-throughput

0.554

High

1366151

RA54B
DNA repair and recombination protein RAD54B

1

8

High-throughput

0.541

High

162951

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.537

High

130780

TAF4
Transcription initiation factor TFIID subunit 4

1

4

High-throughput

0.536

High

391387

FRIL
Ferritin light chain

1

3

High-throughput

0.536

High

423813

APOD
Apolipoprotein D

1

1

High-throughput

0.536

High

866773

CAZA2
F-actin-capping protein subunit alpha-2

1

3

High-throughput

0.536

High

965125

WDR5
WD repeat-containing protein 5

1

13

High-throughput

0.536

High

992892

RACK1
Small ribosomal subunit protein RACK1

1

16

High-throughput

0.536

High

1025731

PURA
Transcriptional activator protein Pur-alpha

1

5

High-throughput

0.536

High

1066731

NCBP1
Nuclear cap-binding protein subunit 1

1

2

High-throughput

0.536

High

1145502

RBBP5
Retinoblastoma-binding protein 5

1

15

High-throughput

0.536

High

1149784

TAF5
Transcription initiation factor TFIID subunit 5

1

13

High-throughput

0.536

High

1241279

TAF2
Transcription initiation factor TFIID subunit 2

1

3

High-throughput

0.536

High

1248049

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

2

High-throughput

0.536

High

1250024

WDR82
WD repeat-containing protein 82

1

19

High-throughput

0.536

High

1259127

LARP4
La-related protein 4

1

20

High-throughput

0.536

High

1271470

DHX30
ATP-dependent RNA helicase DHX30

1

8

High-throughput

0.536

High

1271763

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.536

High

1290623

ZCH18
Zinc finger CCCH domain-containing protein 18

1

19

High-throughput

0.536

High

1324444

CLASR
CLK4-associating serine/arginine rich protein

1

7

High-throughput

0.536

High

1351921

RBCC1
RB1-inducible coiled-coil protein 1

1

20

High-throughput

0.536

High

1352123

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

15

High-throughput

0.536

High

1363285

DDX1
ATP-dependent RNA helicase DDX1

1

15

High-throughput

0.536

High

1366126

SRRT
Serrate RNA effector molecule homolog

1

2

High-throughput

0.536

High

1366131

MOV10
Helicase MOV-10

1

7

High-throughput

0.536

High

1366135

DBLOH
Diablo IAP-binding mitochondrial protein

1

1

High-throughput

0.536

High

1366136

NDE1
Nuclear distribution protein nudE homolog 1

1

20

High-throughput

0.536

High

1366139

CXXC1
CXXC-type zinc finger protein 1

1

8

High-throughput

0.536

High

1366140

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

15

High-throughput

0.536

High

1366152

CFA20
Cilia- and flagella-associated protein 20

1

1

High-throughput

0.536

High

1366130

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

0

High-throughput

0.530

High

67489

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.513

High

329782

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

High-throughput

0.513

High

892056

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.513

High

1136476

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

1241452

XRRA1
X-ray radiation resistance-associated protein 1

1

0

High-throughput

0.513

High

1366125

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.513

High

530155

TAU
Microtubule-associated protein tau

1

16

Small-scale

0.501

High

906724

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

6

Small-scale

0.501

High

1095915

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

6

Small-scale

0.501

High

1102218

ATM
Serine-protein kinase ATM

1

5

Small-scale

0.501

High

1011850

RT05
Small ribosomal subunit protein uS5m

1

3

High-throughput

0.489

High

1366142

PNMA2
Paraneoplastic antigen Ma2

1

3

High-throughput

0.489

High

1366147

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

2

High-throughput

0.489

High

123154

DX39A
ATP-dependent RNA helicase DDX39A

1

15

High-throughput

0.479

High

164160

KIF3C
Kinesin-like protein KIF3C

1

8

High-throughput

0.479

High

176616

KIF3B
Kinesin-like protein KIF3B

1

8

High-throughput

0.479

High

213214

CP110
Centriolar coiled-coil protein of 110 kDa

1

2

Small-scale

0.479

High

414324

P53
Cellular tumor antigen p53

1

12

High-throughput

0.479

High

428887

RLA0
Large ribosomal subunit protein uL10

1

4

Small-scale

0.479

High

447273

NPM
Nucleophosmin

1

5

Small-scale

0.479

High

481345

HMGB1
High mobility group protein B1

1

17

High-throughput

0.479

High

535364

BIP
Endoplasmic reticulum chaperone BiP

1

12

Small-scale

0.479

High

537625

HSP7C
Heat shock cognate 71 kDa protein

1

9

Small-scale

0.479

High

539217

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

3

Small-scale

0.479

High

570941

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.479

High

586808

RS2
Small ribosomal subunit protein uS5

1

3

Small-scale

0.479

High

600886

HSP76
Heat shock 70 kDa protein 6

1

9

Small-scale

0.479

High

608679

DDX5
Probable ATP-dependent RNA helicase DDX5

1

8

High-throughput

0.479

High

612721

RL7
Large ribosomal subunit protein uL30

1

3

Small-scale

0.479

High

686315

RL13
Large ribosomal subunit protein eL13

1

4

High-throughput

0.479

High

696094

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

Small-scale

0.479

High

730806

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

785334

RL4
Large ribosomal subunit protein uL4

1

3

Small-scale

0.479

High

788123

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

Small-scale

0.479

High

859007

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.479

High

961072

MGN
Protein mago nashi homolog

1

2

High-throughput

0.479

High

964695

DCAF7
DDB1- and CUL4-associated factor 7

1

20

Small-scale

0.479

High

970009

RS16
Small ribosomal subunit protein uS9

1

3

High-throughput

0.479

High

971845

1433E
14-3-3 protein epsilon

1

14

High-throughput

0.479

High

975838

RL7A
Large ribosomal subunit protein eL8

1

3

Small-scale

0.479

High

991384

SUMO1
Small ubiquitin-related modifier 1

1

7

High-throughput

0.479

High

993681

UBC9
SUMO-conjugating enzyme UBC9

1

12

High-throughput

0.479

High

995454

TPM4
Tropomyosin alpha-4 chain

1

14

High-throughput

0.479

High

1006156

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

7

High-throughput

0.479

High

1008265

PRKDC
DNA-dependent protein kinase catalytic subunit

1

4

High-throughput

0.479

High

1010765

SSBP2
Single-stranded DNA-binding protein 2

1

4

Small-scale

0.479

High

1027634

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

16

Small-scale

0.479

High

1039972

AKA12
A-kinase anchor protein 12

1

20

High-throughput

0.479

High

1057830

RL18
Large ribosomal subunit protein eL18

1

2

Small-scale

0.479

High

1191452

GRDN
Girdin

1

20

High-throughput

0.479

High

1213519

UBAP2
Ubiquitin-associated protein 2

1

8

High-throughput

0.479

High

1251397

GGYF2
GRB10-interacting GYF protein 2

1

20

High-throughput

0.479

High

1323110

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

High-throughput

0.479

High

1327637

NKAP
NF-kappa-B-activating protein

1

2

High-throughput

0.479

High

1366110

RENT1
Regulator of nonsense transcripts 1

1

6

High-throughput

0.479

High

1366113

MGN2
Protein mago nashi homolog 2

1

2

High-throughput

0.479

High

1366114

MOAP1
Modulator of apoptosis 1

1

3

Small-scale

0.479

High

1366117

FUBP3
Far upstream element-binding protein 3

1

15

High-throughput

0.479

High

1366122

TBA1C
Tubulin alpha-1C chain

1

15

Small-scale

0.479

High

1366124

KIFC1
Kinesin-like protein KIFC1

1

6

High-throughput

0.479

High

1366129

SAV1
Protein salvador homolog 1

1

14

High-throughput

0.479

High

1366150

YTHD2
YTH domain-containing family protein 2

1

9

High-throughput

0.479

High

1366146

CHSP1
Calcium-regulated heat-stable protein 1

1

0

Small-scale

0.464

High

902537

RT29
Small ribosomal subunit protein mS29

1

0

Small-scale

0.458

High

1094068

RM28
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.458

High

1179341

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.458

High

1366116

LTV1
Protein LTV1 homolog

1

0

High-throughput

0.458

High

1366138

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.458

High

576127

CX6B1
Cytochrome c oxidase subunit 6B1

1

1

High-throughput

0.437

High

1024420

S25A3
Solute carrier family 25 member 3

1

15

Small-scale

0.437

High

1348671

SHKB1
SH3KBP1-binding protein 1

1

8

High-throughput

0.437

High

1163596

RTN1
Reticulon-1

2

0

High-throughput

0.328

High

1366121

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.299

High

155611

NEMP1
Nuclear envelope integral membrane protein 1

1

0

High-throughput

0.249

Low

1366112

RM24
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.249

Low

1366119

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025