HitPredict

Interactor 1: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Interactor 2: SRS12 (Q8WXF0)
Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)
Gene: SRSF12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	La~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 582 Hs			1 261
+	Hs
		951983 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		963998 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		SRSF2_HUMAN (4-90): 1.12e-22: 94.6: 45.65
+	Hs
		1031352 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		PABP4_HUMAN (2-101): 2.19e-20: 92.1: 18.00
+	Hs
		516541 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		1116542 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		PABP3_HUMAN (2-101): 1.25e-17: 84: 16.00
+	Mm
		985649 LARP7_MOUSE (8-582): 1.3e-120: 370: 79.20		SRSF2_MOUSE (4-90): 1.12e-22: 94.6: 45.65
+	Hs
		1084289 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	Hs
		403370 LA_HUMAN (24-365): 5.96e-44: 163: 18.83		PPIE_HUMAN (10-98): 7.46e-34: 126: 33.71
+	Hs
		266904 PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	At
		285478 LRP6B_ARATH (2-265): 6.42e-54: 194: 21.20		PABP8_ARATH (2-98): 5.72e-18: 84.8: 17.53
+	Sc
		376709 LHP1_YEAST (7-270): 1.34e-45: 163: 22.74		PABP_YEAST (2-98): 1.48e-20: 92.5: 22.68
+	Hs
		403212 LA_HUMAN (24-365): 5.96e-44: 163: 18.83		PABP4_HUMAN (2-101): 2.19e-20: 92.1: 18.00
+	Hs
		516466 PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		952008 LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		516689 PABP3_HUMAN (1-333): 6.27e-42: 162: 10.11		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		516495 PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		516339 PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		516568 LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		516471 PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29		TIAR_HUMAN (4-98): 1.93e-17: 82.5: 16.84