HitPredict

Interactor 1: MYPC2 (Q14324)
Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)
Gene: MYBPC2

Interactor 2: COCA1 (Q99715)
Collagen alpha-1(XII) chain
Gene: COL12A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	23414517
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	fn3~fn3, I-set~fn3
Common GO terms	GO:0007155 - cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1141 Hs			1 3063
+	Hs
		1125796 MYPC2_HUMAN (1-1141): 0: 696: 100.00		TITIN_HUMAN (1747-1951): 6.9e-09: 64.3: 8.33
+	Hs
		658833 NRCAM_HUMAN (529-1140): 4.66e-45: 180: 12.71		PTPRB_HUMAN (10-1752): 3.85e-94: 344: 14.33
+	Hs
		658820 CNTN1_HUMAN (3-727): 1.67e-34: 145: 9.56		PTPRB_HUMAN (10-1752): 3.85e-94: 344: 14.33
+	Mm
		1250401 DSCAM_MOUSE (430-1140): 1.52e-42: 172: 12.20		SDK2_MOUSE (1380-2614): 1.67e-85: 316: 11.80
+	Hs
		658822 PTPRS_HUMAN (503-867): 1.21e-14: 81.5: 12.01		PTPRB_HUMAN (10-1752): 3.85e-94: 344: 14.33
+	Mm
		98424 E9QPR7_MOUSE (12-740): 2.69e-19: 96.8: 10.98		SDK2_MOUSE (1380-2614): 1.67e-85: 316: 11.80
+	Mm
		1250400 SDK2_MOUSE (523-1036): 1.3e-18: 94.4: 12.73		SDK2_MOUSE (1380-2614): 1.67e-85: 316: 11.80
+	Dm
		1070145 DSCA1_DROME (545-1140): 1.78e-41: 169: 11.97		DSCA1_DROME (11-741): 3.71e-49: 196: 11.82
+	Mm
		1190058 SDK1_MOUSE (15-905): 1.64e-17: 91: 11.84		SDK1_MOUSE (1472-2706): 1.57e-65: 250: 11.56
+	Dm
		1069272 Q0E8G9_DROME (526-1140): 3.35e-40: 164: 12.83		Q0E8G9_DROME (1-643): 1.11e-29: 132: 10.16
+	Dm
		122136 M9PHS6_DROME (526-1140): 4.03e-40: 164: 12.83		M9PHS6_DROME (1-643): 1.22e-29: 132: 10.16
+	Dm
		1269033 Q7KSE9_DROME (8-845): 1.29e-45: 182: 13.62		Q7KSE9_DROME (8-458): 5.82e-15: 84.3: 11.63
+	Dm
		1472863 Q9VEJ5_DROME (8-845): 1.55e-45: 182: 13.62		Q9VEJ5_DROME (8-458): 7.68e-15: 84: 11.63
+	Hs
		522657 PTPRS_HUMAN (503-867): 1.21e-14: 81.5: 12.01		PTPRF_HUMAN (3-737): 6.72e-45: 182: 10.75
+	Hs
		522574 PTPRF_HUMAN (1045-1139): 6.44e-14: 79.2: 27.55		PTPRF_HUMAN (3-737): 6.72e-45: 182: 10.75
+	Hs
		658881 PTPRS_HUMAN (503-867): 1.21e-14: 81.5: 12.01		PTPRD_HUMAN (8-620): 9.6e-40: 166: 10.61
+	Hs
		1133324 MYPC3_HUMAN (1-639): 8.95e-38: 156: 12.15		TITIN_HUMAN (1747-1951): 6.9e-09: 64.3: 8.33
+	Hs
		1102694 PTPRS_HUMAN (503-867): 1.21e-14: 81.5: 12.01		PTPRS_HUMAN (1-583): 2.14e-29: 131: 13.67
+	Dm
		1485316 DSCL_DROME (829-1140): 2.86e-17: 89.9: 14.46		DSCL_DROME (8-453): 1.12e-18: 96.7: 11.33
+	Hs
		928840 MYOM2_HUMAN (77-540): 1.75e-20: 100: 15.08		TITIN_HUMAN (1747-1951): 6.9e-09: 64.3: 8.33