Protein: PTPRB
Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)

Gene: PTPRB
Organism: Homo sapiens
Interactions: 59
UniProt ID: P23467

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001649 - osteoblast differentiation
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 - plasma membrane
GO:0006470 - protein dephosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

362778

EGFR
Epidermal growth factor receptor

4

20

Small-scale

0.885

High

533830

GHR
Growth hormone receptor

2

17

Small-scale

0.802

High

658820

CNTN1
Contactin-1

2

19

Small-scale

0.778

High

658826

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

20

Small-scale

0.740

High

658806

MK03
Mitogen-activated protein kinase 3

2

12

Small-scale

0.712

High

658819

TIE2
Angiopoietin-1 receptor

2

19

Small-scale

0.712

High

658822

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

20

High-throughput

0.691

High

658833

NRCAM
Neuronal cell adhesion molecule

1

17

Small-scale

0.647

High

609952

VGFR1
Vascular endothelial growth factor receptor 1

1

17

Small-scale

0.618

High

658805

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

20

High-throughput

0.618

High

658817

RAB13
Ras-related protein Rab-13

1

5

High-throughput

0.618

High

658837

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.618

High

480704

LEG1
Galectin-1

2

20

Small-scale

0.611

High

193500

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

5

High-throughput

0.575

High

410623

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.575

High

411368

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.575

High

439641

INSR
Insulin receptor

1

20

High-throughput

0.575

High

439950

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.575

High

471988

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.575

High

484056

PGFRB
Platelet-derived growth factor receptor beta

1

19

High-throughput

0.575

High

619205

EPOR
Erythropoietin receptor

1

20

High-throughput

0.575

High

651152

CBL
E3 ubiquitin-protein ligase CBL

1

11

High-throughput

0.575

High

658808

MK01
Mitogen-activated protein kinase 1

1

12

Small-scale

0.575

High

658811

CSK
Tyrosine-protein kinase CSK

1

20

High-throughput

0.575

High

658812

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.575

High

658843

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.575

High

658809

CADH5
Cadherin-5

1

20

Small-scale

0.561

High

658818

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

2

High-throughput

0.553

High

658804

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

20

Small-scale

0.545

High

658838

DDX21
Nucleolar RNA helicase 2

1

7

High-throughput

0.536

High

658832

MADD
MAP kinase-activating death domain protein

1

1

High-throughput

0.515

High

658840

RRBP1
Ribosome-binding protein 1

1

12

High-throughput

0.515

High

658842

COR1C
Coronin-1C

1

9

High-throughput

0.514

High

208182

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.513

High

658813

RBM34
RNA-binding protein 34

1

8

High-throughput

0.489

High

658824

GLYR1
Cytokine-like nuclear factor N-PAC

1

1

High-throughput

0.489

High

658827

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

4

High-throughput

0.489

High

658836

DDX31
ATP-dependent DNA helicase DDX31

1

7

High-throughput

0.489

High

658839

RBM28
RNA-binding protein 28

1

5

High-throughput

0.489

High

585435

VEGFA
Vascular endothelial growth factor A, long form

1

4

Small-scale

0.479

High

618215

CADH2
Cadherin-2

1

20

High-throughput

0.445

High

643411

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

2

High-throughput

0.445

High

658810

CTNB1
Catenin beta-1

1

20

High-throughput

0.445

High

658814

WASP
Actin nucleation-promoting factor WAS

1

9

High-throughput

0.445

High

658815

NSF
Vesicle-fusing ATPase

1

10

High-throughput

0.445

High

658816

PAXI
Paxillin

1

18

High-throughput

0.445

High

658821

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

8

High-throughput

0.445

High

658823

GAB1
GRB2-associated-binding protein 1

1

6

High-throughput

0.445

High

658828

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

658831

NUDC2
NudC domain-containing protein 2

1

3

High-throughput

0.437

High

658835

RABE2
Rab GTPase-binding effector protein 2

1

7

High-throughput

0.437

High

658841

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.437

High

658844

RL26L
Ribosomal protein uL24-like

1

2

High-throughput

0.437

High

658807

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.407

High

658834

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

2

High-throughput

0.407

High

658825

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.279

Low

658829

BRX1
Ribosome biogenesis protein BRX1 homolog

1

0

High-throughput

0.279

Low

658830

NOC3L
Nucleolar complex protein 3 homolog

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025