Interactor 1: LRRK2 (Q5S006)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-)
Gene: LRRK2

Interactor 2: LRRK2 (Q5S006)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-)
Gene: LRRK2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.927

The method score is based on:

Property Details
Experiments 20659021, 17623048, 21390248, 27357661, 22952686
Identification Methods enzymatic study, affinity chromatography technology, blue native page, electron microscopy, protein kinase assay, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains COR~COR, COR~Roc, LRR_1~LRR_1, LRR_1~LRR_8, LRR_8~LRR_8, Pkinase~Pkinase, Roc~Roc
Common GO terms GO:0000139 - Golgi membrane
GO:0000287 - magnesium ion binding
GO:0001933 - negative regulation of protein phosphorylation
GO:0001934 - positive regulation of protein phosphorylation
GO:0003779 - actin binding
and 126 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 2527
Mm

1 2527
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Last updated: 15 Jul 2024