Protein: FGD1
FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3)

Gene: FGD1
Organism: Homo sapiens
Interactions: 41
UniProt ID: P98174

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1023019

SPD2A
SH3 and PX domain-containing protein 2A

4

15

High-throughput

0.881

High

955059

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.778

High

1023029

OSBL8
Oxysterol-binding protein-related protein 8

1

1

High-throughput

0.691

High

1023021

WDR74
WD repeat-containing protein 74

2

10

High-throughput

0.659

High

1023022

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

12

High-throughput

0.621

High

375408

RASK
GTPase KRas

1

18

High-throughput

0.618

High

440027

LCK
Tyrosine-protein kinase Lck

1

17

High-throughput

0.618

High

648482

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

974981

ARF6
ADP-ribosylation factor 6

1

6

High-throughput

0.618

High

1023038

FBW1A
F-box/WD repeat-containing protein 1A

1

4

Small-scale

0.618

High

904599

MECP2
Methyl-CpG-binding protein 2

2

8

High-throughput

0.571

High

1023023

PABP2
Polyadenylate-binding protein 2

2

9

High-throughput

0.571

High

1023026

DAZP1
DAZ-associated protein 1

2

11

High-throughput

0.571

High

1023024

AROS
Active regulator of SIRT1

2

0

High-throughput

0.547

High

1023015

STX3
Syntaxin-3

1

3

High-throughput

0.536

High

1023020

FXL19
F-box/LRR-repeat protein 19

1

2

High-throughput

0.536

High

1023025

MILK2
MICAL-like protein 2

1

14

High-throughput

0.536

High

1013043

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

2

2

High-throughput

0.521

High

1014070

CBX1
Chromobox protein homolog 1

2

3

High-throughput

0.521

High

1023018

HP1B3
Heterochromatin protein 1-binding protein 3

2

2

High-throughput

0.521

High

1023035

CWC15
Spliceosome-associated protein CWC15 homolog

2

1

High-throughput

0.521

High

612603

RL7
Large ribosomal subunit protein uL30

1

2

High-throughput

0.515

High

85206

B7Z9C6
SH3 and PX domain-containing protein 2A

1

15

High-throughput

0.514

High

140505

PITM1
Membrane-associated phosphatidylinositol transfer protein 1

1

0

High-throughput

0.513

High

1023033

INT7
Integrator complex subunit 7

1

0

High-throughput

0.513

High

48603

ESYT2
Extended synaptotagmin-2

1

3

High-throughput

0.479

High

424389

HMGN1
Non-histone chromosomal protein HMG-14

1

3

High-throughput

0.479

High

1004030

CXAR
Coxsackievirus and adenovirus receptor

1

4

High-throughput

0.479

High

1023016

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1023036

XPO7
Exportin-7

1

9

High-throughput

0.479

High

1023037

SMC3
Structural maintenance of chromosomes protein 3

1

6

High-throughput

0.479

High

116440

H7BXI1
Extended synaptotagmin-2

1

7

High-throughput

0.445

High

1023017

AINX
Alpha-internexin

1

20

High-throughput

0.437

High

1023027

RBM15
RNA-binding protein 15

1

8

High-throughput

0.437

High

1023028

SF3B5
Splicing factor 3B subunit 5

1

2

High-throughput

0.437

High

1023031

CCD86
Coiled-coil domain-containing protein 86

1

3

High-throughput

0.437

High

1023034

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

4

High-throughput

0.437

High

1023032

SLX9
Ribosome biogenesis protein SLX9 homolog

2

0

High-throughput

0.298

High

800208

VKGC
Vitamin K-dependent gamma-carboxylase

1

0

High-throughput

0.279

Low

1023014

TAP2
Antigen peptide transporter 2

1

0

High-throughput

0.279

Low

1023030

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025