Protein: MED22
Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5)

Gene: MED22
Organism: Homo sapiens
Interactions: 78
UniProt ID: Q15528

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0016592 - mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1074730

MED17
Mediator of RNA polymerase II transcription subunit 17

5

1

Small-scale

0.927

High

1074734

MED11
Mediator of RNA polymerase II transcription subunit 11

4

2

Small-scale

0.911

High

1074725

MED18
Mediator of RNA polymerase II transcription subunit 18

6

0

Small-scale

0.902

High

1074727

MED28
Mediator of RNA polymerase II transcription subunit 28

6

0

Small-scale

0.897

High

1074719

MED30
Mediator of RNA polymerase II transcription subunit 30

5

0

Small-scale

0.887

High

270503

MED6
Mediator of RNA polymerase II transcription subunit 6

3

3

High-throughput

0.861

High

1074717

MED8
Mediator of RNA polymerase II transcription subunit 8

3

0

High-throughput

0.816

High

826279

CDK8
Cyclin-dependent kinase 8

9

3

Small-scale

0.752

High

1074726

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.733

High

48670

MED19
Mediator of RNA polymerase II transcription subunit 19

8

0

Small-scale

0.717

High

1074724

MED10
Mediator of RNA polymerase II transcription subunit 10

8

0

Small-scale

0.717

High

624434

CCNC
Cyclin-C

5

1

High-throughput

0.714

High

1074731

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.705

High

1074732

MED29
Mediator of RNA polymerase II transcription subunit 29

6

0

Small-scale

0.702

High

1074728

MED20
Mediator of RNA polymerase II transcription subunit 20

4

1

High-throughput

0.699

High

1074701

MED1
Mediator of RNA polymerase II transcription subunit 1

6

0

Small-scale

0.699

High

1074707

MED27
Mediator of RNA polymerase II transcription subunit 27

5

0

Small-scale

0.691

High

206621

MED7
Mediator of RNA polymerase II transcription subunit 7

5

0

Small-scale

0.689

High

1074715

MED12
Mediator of RNA polymerase II transcription subunit 12

4

2

High-throughput

0.686

High

1037051

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

High-throughput

0.674

High

1074729

MED4
Mediator of RNA polymerase II transcription subunit 4

4

0

High-throughput

0.672

High

225381

MED14
Mediator of RNA polymerase II transcription subunit 14

3

1

High-throughput

0.667

High

313424

MED26
Mediator of RNA polymerase II transcription subunit 26

3

1

High-throughput

0.667

High

1074735

MED13
Mediator of RNA polymerase II transcription subunit 13

3

1

High-throughput

0.662

High

1074709

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

1

High-throughput

0.650

High

1074739

MED31
Mediator of RNA polymerase II transcription subunit 31

3

0

High-throughput

0.646

High

265327

MED24
Mediator of RNA polymerase II transcription subunit 24

3

0

High-throughput

0.638

High

1074738

MED16
Mediator of RNA polymerase II transcription subunit 16

3

0

High-throughput

0.638

High

1074711

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

2

High-throughput

0.611

High

1074720

MED15
Mediator of RNA polymerase II transcription subunit 15

2

1

High-throughput

0.611

High

147245

TXND9
Thioredoxin domain-containing protein 9

2

1

High-throughput

0.606

High

177686

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

1074740

FBX7
F-box only protein 7

2

0

High-throughput

0.592

High

583483

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.585

High

854419

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

0

High-throughput

0.585

High

1074737

MED23
Mediator of RNA polymerase II transcription subunit 23

2

0

High-throughput

0.585

High

244484

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

1074718

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1074722

DCTN5
Dynactin subunit 5

1

1

High-throughput

0.536

High

181418

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.513

High

818077

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

1074710

MED25
Mediator of RNA polymerase II transcription subunit 25

1

0

High-throughput

0.513

High

1074723

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.513

High

1074736

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.513

High

791581

HD
Huntingtin

1

0

High-throughput

0.493

High

893357

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

1074706

THOC7
THO complex subunit 7 homolog

1

0

Small-scale

0.480

High

377343

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

487464

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

631432

BRD2
Bromodomain-containing protein 2

1

1

High-throughput

0.479

High

1074702

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

1074703

SMAD1
Mothers against decapentaplegic homolog 1

1

1

Small-scale

0.479

High

266360

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.458

High

583715

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.458

High

624905

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

676890

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.458

High

738845

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

779473

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

854305

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

913898

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

1018965

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1074708

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1074712

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1074716

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1074721

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

73028

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

3

High-throughput

0.445

High

91298

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1074704

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

831352

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

329031

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

160009

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

0

High-throughput

0.316

High

1074713

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.282

High

126692

DCTN6
Dynactin subunit 6

1

0

High-throughput

0.279

Low

278615

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.279

Low

1074714

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1074733

ARP10
Actin-related protein 10

1

0

High-throughput

0.279

Low

281635

WFS1
Wolframin

1

0

High-throughput

0.268

Low

1074705

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024