Protein: ARHG4
Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1)

Gene: ARHG4, ARHGEF4
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q9NR80

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0019904 - protein domain specific binding
GO:0030032 - lamellipodium assembly
GO:0032587 - ruffle membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

988741

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.800

High

955644

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.778

High

962529

RHOA
Transforming protein RhoA

2

20

Small-scale

0.778

High

668725

APC
Adenomatous polyposis coli protein

4

8

Small-scale

0.703

High

66460

ASB14
Ankyrin repeat and SOCS box protein 14

1

5

High-throughput

0.691

High

966917

1433G
14-3-3 protein gamma

3

20

High-throughput

0.650

High

1049821

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

366442

FA12
Coagulation factor XII

1

2

High-throughput

0.618

High

1315859

AN13A
Ankyrin repeat domain-containing protein 13A

1

5

High-throughput

0.618

High

414690

P53
Cellular tumor antigen p53

1

3

High-throughput

0.618

High

1398886

SPT13
Spermatogenesis-associated protein 13

1

16

Small-scale

0.618

High

691465

1433T
14-3-3 protein theta

2

20

High-throughput

0.611

High

972040

1433E
14-3-3 protein epsilon

2

4

High-throughput

0.611

High

990776

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

269390

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

1154938

NEDD8
Ubiquitin-like protein NEDD8

1

1

Small-scale

0.575

High

1448061

SLAI2
SLAIN motif-containing protein 2

2

1

High-throughput

0.571

High

941277

IF6
Eukaryotic translation initiation factor 6

2

0

High-throughput

0.547

High

1339194

NUP35
Nucleoporin NUP35

2

0

High-throughput

0.547

High

296833

ST1C4
Sulfotransferase 1C4

1

1

High-throughput

0.536

High

1429758

BTBD1
BTB/POZ domain-containing protein 1

1

6

High-throughput

0.536

High

1247294

WDR74
WD repeat-containing protein 74

2

5

High-throughput

0.521

High

1393961

FUBP3
Far upstream element-binding protein 3

2

4

High-throughput

0.521

High

1448059

RBM22
Pre-mRNA-splicing factor RBM22

2

3

High-throughput

0.521

High

459850

PMGE
Bisphosphoglycerate mutase

1

0

High-throughput

0.513

High

1434750

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

320297

TMCC1
Transmembrane and coiled-coil domains protein 1

1

0

High-throughput

0.493

High

1177099

INF2
Inverted formin-2

1

1

High-throughput

0.489

High

299394

FLOT1
Flotillin-1

1

8

High-throughput

0.479

High

321673

PRP6
Pre-mRNA-processing factor 6

1

1

High-throughput

0.479

High

483229

CLCA
Clathrin light chain A

1

4

High-throughput

0.479

High

656248

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

4

High-throughput

0.479

High

730277

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

920298

PLK1
Serine/threonine-protein kinase PLK1

1

6

High-throughput

0.479

High

973096

RS29
Small ribosomal subunit protein uS14

1

1

High-throughput

0.479

High

974060

RUXF
Small nuclear ribonucleoprotein F

1

3

High-throughput

0.479

High

1024203

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

1121892

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

16

High-throughput

0.479

High

1130196

SMC1A
Structural maintenance of chromosomes protein 1A

1

3

High-throughput

0.479

High

1143279

PLEC
Plectin

1

12

High-throughput

0.479

High

1356406

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

4

High-throughput

0.479

High

1448062

TPX2
Targeting protein for Xklp2

1

4

High-throughput

0.479

High

1448064

SMC3
Structural maintenance of chromosomes protein 3

1

3

High-throughput

0.479

High

1023625

CYC
Cytochrome c

1

0

High-throughput

0.458

High

161091

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

6

Small-scale

0.457

High

1448057

DISC1
Disrupted in schizophrenia 1 protein

1

7

High-throughput

0.457

High

1448058

EXOC1
Exocyst complex component 1

1

3

High-throughput

0.457

High

533775

CLUS
Clusterin

1

0

High-throughput

0.438

High

895663

SERPH
Serpin H1

1

4

High-throughput

0.437

High

1434926

CCD86
Coiled-coil domain-containing protein 86

1

1

High-throughput

0.437

High

1448060

MIC19
MICOS complex subunit MIC19

1

2

High-throughput

0.437

High

380159

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.417

High

1059977

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

6

Small-scale

0.408

High

1153601

MLF2
Myeloid leukemia factor 2

2

0

High-throughput

0.298

High

1168583

KNOP1
Lysine-rich nucleolar protein 1

2

0

High-throughput

0.298

High

1407713

EBP2
Probable rRNA-processing protein EBP2

2

0

High-throughput

0.298

High

1325842

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1448063

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.279

Low

352251

MBD3
Methyl-CpG-binding domain protein 3

1

0

High-throughput

0.249

Low

1206903

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.249

Low

1245423

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

0

High-throughput

0.249

Low

1420464

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025