HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: TBA1C (Q9BQE3)
Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]
Gene: TUBA1C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	18214993, 24275654
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005525 - GTP binding GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 449
+	Hs
		1120842 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		Q53GA7_HUMAN (1-449): 0: 732: 99.78
+	Hs
		933472 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBA4A_HUMAN (1-448): 0: 724: 96.21
+	Hs
		933229 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBA1B_HUMAN (1-439): 0: 717: 99.09
+	Hs
		1130237 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBA1A_HUMAN (1-439): 0: 715: 99.09
+	Hs
		428247 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		1130537 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB2B_HUMAN (1-440): 0: 697: 40.23
+	Hs
		933841 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		782771 CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74		TBA1B_HUMAN (1-439): 0: 717: 99.09
+	Hs
		428238 LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		933832 LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		201179 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		201419 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		TBB2B_HUMAN (1-440): 0: 697: 40.23