HitPredict

Interactor 1: PHF12 (Q5SPL2)
PHD finger protein 12 (PHD factor 1) (Pf1)
Gene: PHF12

Interactor 2: SIN3B (Q62141)
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
Gene: SIN3B

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21041482
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PAH~PHF12_MRG_bd
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1003 Mm			1 1098
+	Hs
		257821 PHF12_HUMAN (1-1003): 0: 1467: 95.92		SIN3B_HUMAN (14-1098): 0: 1304: 86.89
+	Hs
		1300603 PHF12_HUMAN (1-1003): 0: 1467: 95.92		SIN3A_HUMAN (71-357): 1.1e-12: 74.9: 14.49
+	Hs
		257817 PF21A_HUMAN (227-329): 3.63e-17: 88.8: 21.36		SIN3B_HUMAN (14-1098): 0: 1304: 86.89
+	Hs
		257744 KDM5A_HUMAN (41-112): 1.25e-16: 87.6: 25.33		SIN3B_HUMAN (14-1098): 0: 1304: 86.89
+	Hs
		257774 CHD3_HUMAN (161-324): 1.64e-12: 74.1: 14.84		SIN3B_HUMAN (14-1098): 0: 1304: 86.89
+	Hs
		257809 CHD5_HUMAN (261-324): 3.96e-11: 69.5: 29.69		SIN3B_HUMAN (14-1098): 0: 1304: 86.89
+	Ce
		60878 Q18605_CAEEL (1-354): 7.79e-63: 234: 20.11		SIN3_CAEEL (4-156): 7.01e-31: 134: 31.82
+	Dm
		1137187 Q9W410_DROME (790-963): 5.02e-71: 255: 34.98		Q5U0Y0_DROME (134-264): 5.22e-23: 108: 41.79
+	Sp
		143537 YAC5_SCHPO (25-106): 1.37e-22: 103: 32.93		PST2_SCHPO (697-1042): 1.36e-58: 222: 19.83
+	Zm
		29277 A0A1D6JZC0_MAIZE (49-104): 1.71e-14: 80.6: 37.50		A0A1D6MNA1_MAIZE (29-297): 1.58e-50: 197: 29.56
+	Sc
		609142 RCO1_YEAST (31-105): 6.93e-21: 100: 32.00		SIN3_YEAST (31-137): 1.11e-25: 117: 46.79
+	Ce
		60807 LE418_CAEEL (51-114): 3.66e-14: 79.4: 34.38		SIN3_CAEEL (4-156): 7.01e-31: 134: 31.82
+	Hs
		1289744 PF21B_HUMAN (3-223): 9.17e-31: 130: 18.10		SIN3A_HUMAN (71-357): 1.1e-12: 74.9: 14.49
+	Hs
		1029772 TIF1B_HUMAN (23-240): 2.44e-27: 121: 19.03		SIN3A_HUMAN (71-357): 1.1e-12: 74.9: 14.49
+	Dm
		1137172 KDM5_DROME (29-112): 1.41e-15: 84.1: 26.37		Q5U0Y0_DROME (134-264): 5.22e-23: 108: 41.79
+	Mm
		1141048 KDM5B_MOUSE (24-112): 3.96e-19: 95.7: 29.35		SIN3A_MOUSE (71-357): 1.33e-12: 74.5: 14.49
+	Hs
		1018652 CHD3_HUMAN (161-324): 1.64e-12: 74.1: 14.84		SIN3A_HUMAN (71-357): 1.1e-12: 74.9: 14.49
+	Hs
		1059812 CHD4_HUMAN (270-348): 6.56e-12: 72.2: 22.79		SIN3A_HUMAN (71-357): 1.1e-12: 74.9: 14.49