HitPredict

Interactor 1: UBE2U (Q5VVX9)
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)
Gene: UBE2U

Interactor 2: TRIM5 (Q9C035)
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)
Gene: TRIM5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0000209 - protein polyubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 321 Hs			1 493
+	Hs
		536873 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21
+	Hs
		1138878 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI68_HUMAN (1-492): 1.14e-120: 363: 32.68
+	Hs
		1138916 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI34_HUMAN (1-493): 9.36e-114: 346: 55.75
+	Hs
		135028 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI38_HUMAN (1-491): 1.02e-110: 337: 31.65
+	Hs
		1138931 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI35_HUMAN (2-491): 7.11e-93: 292: 21.40
+	Hs
		1138919 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI15_HUMAN (2-488): 1.83e-91: 288: 22.89
+	Hs
		1318719 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRIM5_HUMAN (1-493): 3.88e-147: 432: 100.00
+	Hs
		1336390 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI39_HUMAN (6-492): 6.9e-127: 381: 27.48
+	Hs
		537142 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21
+	Hs
		536779 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21
+	Mm
		919925 UB2D2_MOUSE (4-153): 8.78e-76: 230: 34.67		TRI17_MOUSE (2-492): 9.71e-112: 340: 27.60
+	Hs
		135045 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI38_HUMAN (1-491): 1.02e-110: 337: 31.65
+	Hs
		135019 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		TRI38_HUMAN (1-491): 1.02e-110: 337: 31.65
+	Hs
		1377469 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI17_HUMAN (2-492): 1.67e-104: 322: 26.80
+	Hs
		1285831 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI43_HUMAN (1-480): 2.81e-101: 313: 24.74
+	Hs
		1354526 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI10_HUMAN (1-490): 6.71e-101: 313: 24.60
+	Hs
		1204911 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI50_HUMAN (5-481): 4.35e-98: 306: 24.74
+	Hs
		1313765 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI62_HUMAN (8-488): 7.8e-95: 297: 23.22
+	Hs
		1357712 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI35_HUMAN (2-491): 7.11e-93: 292: 21.40
+	Hs
		1318532 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI31_HUMAN (1-269): 5.66e-40: 150: 31.25