Protein: MED12
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)

Gene: MED12
Organism: Homo sapiens
Interactions: 179
UniProt ID: Q93074

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001843 - neural tube closure
GO:0003682 - chromatin binding
GO:0003712 - transcription coregulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1372187

MED10
Mediator of RNA polymerase II transcription subunit 10

10

2

Small-scale

0.975

High

1372211

MED13
Mediator of RNA polymerase II transcription subunit 13

6

4

High-throughput

0.945

High

1259054

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

4

4

High-throughput

0.895

High

881579

CDK8
Cyclin-dependent kinase 8

21

13

Small-scale

0.765

High

1372189

CDK19
Cyclin-dependent kinase 19

11

12

Small-scale

0.756

High

1151276

MED1
Mediator of RNA polymerase II transcription subunit 1

10

20

Small-scale

0.755

High

48996

MED19
Mediator of RNA polymerase II transcription subunit 19

9

2

Small-scale

0.754

High

1372198

MED4
Mediator of RNA polymerase II transcription subunit 4

8

3

Small-scale

0.752

High

1372188

MED18
Mediator of RNA polymerase II transcription subunit 18

7

2

Small-scale

0.751

High

1108379

MED21
Mediator of RNA polymerase II transcription subunit 21

7

3

High-throughput

0.749

High

1372206

MED29
Mediator of RNA polymerase II transcription subunit 29

7

2

Small-scale

0.749

High

1372196

MED20
Mediator of RNA polymerase II transcription subunit 20

7

1

High-throughput

0.748

High

239602

MED14
Mediator of RNA polymerase II transcription subunit 14

7

19

Small-scale

0.746

High

1372177

MED30
Mediator of RNA polymerase II transcription subunit 30

7

2

Small-scale

0.745

High

666880

CCNC
Cyclin-C

7

6

Small-scale

0.739

High

287807

MED6
Mediator of RNA polymerase II transcription subunit 6

6

2

High-throughput

0.733

High

1241398

MED27
Mediator of RNA polymerase II transcription subunit 27

6

2

High-throughput

0.733

High

1372204

MED17
Mediator of RNA polymerase II transcription subunit 17

6

2

High-throughput

0.732

High

1372205

MED9
Mediator of RNA polymerase II transcription subunit 9

6

1

Small-scale

0.732

High

1372193

MED28
Mediator of RNA polymerase II transcription subunit 28

6

1

Small-scale

0.732

High

219503

MED7
Mediator of RNA polymerase II transcription subunit 7

5

2

High-throughput

0.722

High

1372221

MED31
Mediator of RNA polymerase II transcription subunit 31

5

2

High-throughput

0.722

High

1372207

MED11
Mediator of RNA polymerase II transcription subunit 11

5

2

High-throughput

0.718

High

1372175

MED8
Mediator of RNA polymerase II transcription subunit 8

5

2

High-throughput

0.714

High

1372181

MED15
Mediator of RNA polymerase II transcription subunit 15

5

15

Small-scale

0.714

High

1372213

MED23
Mediator of RNA polymerase II transcription subunit 23

5

6

Small-scale

0.712

High

282406

MED24
Mediator of RNA polymerase II transcription subunit 24

4

2

High-throughput

0.694

High

336016

MED26
Mediator of RNA polymerase II transcription subunit 26

4

1

Small-scale

0.694

High

1259265

MED25
Mediator of RNA polymerase II transcription subunit 25

4

3

Small-scale

0.694

High

1372219

MED16
Mediator of RNA polymerase II transcription subunit 16

4

2

High-throughput

0.694

High

396661

ESR1
Estrogen receptor

4

20

Small-scale

0.689

High

1149698

MED22
Mediator of RNA polymerase II transcription subunit 22

4

2

High-throughput

0.686

High

543525

VDR
Vitamin D3 receptor

3

20

Small-scale

0.664

High

787889

SRBP1
Sterol regulatory element-binding protein 1

3

16

Small-scale

0.641

High

1372172

FBXW7
F-box/WD repeat-containing protein 7

3

8

Small-scale

0.633

High

1093024

CDC16
Cell division cycle protein 16 homolog

2

6

High-throughput

0.628

High

1233776

CNDH2
Condensin-2 complex subunit H2

2

1

High-throughput

0.628

High

1295667

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

18

High-throughput

0.618

High

520262

ANDR
Androgen receptor

2

20

High-throughput

0.612

High

129310

MEN1
Menin

2

7

High-throughput

0.611

High

854206

KI67
Proliferation marker protein Ki-67

2

12

High-throughput

0.611

High

1369145

KAT2A
Histone acetyltransferase KAT2A

2

20

Small-scale

0.601

High

1366957

ESR2
Estrogen receptor beta

2

20

Small-scale

0.585

High

260267

BRD4
Bromodomain-containing protein 4

2

18

Small-scale

0.584

High

1372212

RCOR1
REST corepressor 1

2

13

High-throughput

0.584

High

873116

SOX9
Transcription factor SOX-9

1

20

Small-scale

0.573

High

533299

THA
Thyroid hormone receptor alpha

2

20

Small-scale

0.571

High

1372178

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

6

Small-scale

0.561

High

1372210

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

2

Small-scale

0.561

High

621930

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.559

High

1372197

NANOG
Homeobox protein NANOG

1

20

Small-scale

0.552

High

123795

MYO1C
Unconventional myosin-Ic

1

4

High-throughput

0.536

High

183496

CASC3
Protein CASC3

1

18

High-throughput

0.536

High

1161349

HIF1A
Hypoxia-inducible factor 1-alpha

1

19

Small-scale

0.536

High

1243761

FXL19
F-box/LRR-repeat protein 19

1

4

High-throughput

0.536

High

1329798

SIR6
NAD-dependent protein deacylase sirtuin-6

1

8

High-throughput

0.536

High

1368851

RBP56
TATA-binding protein-associated factor 2N

1

16

High-throughput

0.536

High

887086

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

High-throughput

0.527

High

517551

GLI3
Transcriptional activator GLI3

1

5

Small-scale

0.527

High

788980

TGFR2
TGF-beta receptor type-2

1

1

Small-scale

0.515

High

284856

TADA3
Transcriptional adapter 3

1

0

High-throughput

0.513

High

351145

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.513

High

951323

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

1326763

CCD82
Coiled-coil domain-containing protein 82

1

0

High-throughput

0.513

High

422790

A4
Amyloid-beta precursor protein

1

5

Small-scale

0.501

High

907326

APLP1
Amyloid beta precursor like protein 1

1

5

Small-scale

0.501

High

1055340

APLP2
Amyloid beta precursor like protein 2

1

5

Small-scale

0.501

High

455837

H10
Histone H1.0

1

0

High-throughput

0.493

High

184888

SPTC1
Serine palmitoyltransferase 1

1

2

High-throughput

0.489

High

506409

OCM2
Oncomodulin-2

1

3

High-throughput

0.489

High

1199015

KLH12
Kelch-like protein 12

1

4

High-throughput

0.489

High

1372186

LZTS2
Leucine zipper putative tumor suppressor 2

1

13

High-throughput

0.489

High

1372192

SHRPN
Sharpin

1

2

High-throughput

0.489

High

141603

DDX3X
ATP-dependent RNA helicase DDX3X

1

8

High-throughput

0.479

High

143170

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

173172

XPO1
Exportin-1

1

7

High-throughput

0.479

High

210081

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

246834

KDM1A
Lysine-specific histone demethylase 1A

1

9

High-throughput

0.479

High

283523

TAD2A
Transcriptional adapter 2-alpha

1

11

High-throughput

0.479

High

372764

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

401253

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

17

High-throughput

0.479

High

443905

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

2

High-throughput

0.479

High

474183

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

537649

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.479

High

598165

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.479

High

608691

DDX5
Probable ATP-dependent RNA helicase DDX5

1

8

High-throughput

0.479

High

621704

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

643009

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

667393

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

680453

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

2

High-throughput

0.479

High

687474

PTBP1
Polypyrimidine tract-binding protein 1

1

9

High-throughput

0.479

High

723038

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.479

High

727911

DNJA1
DnaJ homolog subfamily A member 1

1

2

High-throughput

0.479

High

765773

BMI1
Polycomb complex protein BMI-1

1

13

High-throughput

0.479

High

787767

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.479

High

799366

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

831184

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

846409

MATR3
Matrin-3

1

3

High-throughput

0.479

High

862349

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

897929

CDK9
Cyclin-dependent kinase 9

1

6

High-throughput

0.479

High

905003

MECP2
Methyl-CpG-binding protein 2

1

11

High-throughput

0.479

High

910618

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

4

High-throughput

0.479

High

912098

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.479

High

920167

PLK1
Serine/threonine-protein kinase PLK1

1

6

High-throughput

0.479

High

951798

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

981623

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.479

High

986618

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

8

High-throughput

0.479

High

987146

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

High-throughput

0.479

High

1004927

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

1029895

RUNX1
Runt-related transcription factor 1

1

4

High-throughput

0.479

High

1059916

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

4

High-throughput

0.479

High

1087919

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1088948

TP53B
TP53-binding protein 1

1

14

High-throughput

0.479

High

1109963

HDAC1
Histone deacetylase 1

1

8

High-throughput

0.479

High

1113917

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1120273

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

8

Small-scale

0.479

High

1126499

CAPR1
Caprin-1

1

7

High-throughput

0.479

High

1129679

MDC1
Mediator of DNA damage checkpoint protein 1

1

20

High-throughput

0.479

High

1133582

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1134505

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

7

High-throughput

0.479

High

1134672

NUMA1
Nuclear mitotic apparatus protein 1

1

10

High-throughput

0.479

High

1134809

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

20

High-throughput

0.479

High

1151368

TRIP4
Activating signal cointegrator 1

1

1

High-throughput

0.479

High

1212013

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

6

High-throughput

0.479

High

1235667

NIPBL
Nipped-B-like protein

1

15

High-throughput

0.479

High

1257799

ACD11
Acyl-CoA dehydrogenase family member 11

1

1

High-throughput

0.479

High

1336810

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

14

Small-scale

0.479

High

1338310

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1338881

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1372173

WBP2
WW domain-binding protein 2

1

2

High-throughput

0.479

High

1372174

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

15

High-throughput

0.479

High

1372180

QKI
KH domain-containing RNA-binding protein QKI

1

4

High-throughput

0.479

High

1372185

EPAS1
Endothelial PAS domain-containing protein 1

1

19

Small-scale

0.479

High

1372199

DDX21
Nucleolar RNA helicase 2

1

9

High-throughput

0.479

High

1372200

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.479

High

1372202

SMC4
Structural maintenance of chromosomes protein 4

1

4

High-throughput

0.479

High

1372209

HECW2
E3 ubiquitin-protein ligase HECW2

1

8

High-throughput

0.479

High

1372214

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

High-throughput

0.479

High

1372215

PRP19
Pre-mRNA-processing factor 19

1

13

High-throughput

0.479

High

1372217

RUVB1
RuvB-like 1

1

4

High-throughput

0.479

High

1372218

TR150
Thyroid hormone receptor-associated protein 3

1

10

High-throughput

0.479

High

1372222

PKP3
Plakophilin-3

1

12

High-throughput

0.479

High

283617

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

564164

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.458

High

716927

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

876961

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.458

High

959892

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.458

High

969660

RS15A
Small ribosomal subunit protein uS8

1

0

High-throughput

0.458

High

976126

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

1372179

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1372190

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.458

High

1372195

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1372220

NOP58
Nucleolar protein 58

1

0

High-throughput

0.458

High

1372224

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

65432

A6NG10
WW domain binding protein 2

1

1

High-throughput

0.445

High

96943

E9PGW7
Mediator of RNA polymerase II transcription subunit 22

1

2

High-throughput

0.445

High

253973

LPXN
Leupaxin

1

10

High-throughput

0.445

High

844848

EAA1
Excitatory amino acid transporter 1

1

2

High-throughput

0.445

High

845095

EAA3
Excitatory amino acid transporter 3

1

2

High-throughput

0.445

High

1372182

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1372183

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.445

High

1372201

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

3

High-throughput

0.445

High

1372223

TRRAP
Transformation/transcription domain-associated protein

1

7

Small-scale

0.445

High

1372184

LYST
Lysosomal-trafficking regulator

1

10

Small-scale

0.439

High

347223

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.437

High

412393

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.437

High

1254932

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1372176

DDX27
Probable ATP-dependent RNA helicase DDX27

1

8

High-throughput

0.437

High

1372194

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1372216

G3BP2
Ras GTPase-activating protein-binding protein 2

1

5

High-throughput

0.437

High

1372203

S39A9
Zinc transporter ZIP9

1

0

High-throughput

0.426

High

76431

B4DUB1
cyclin-dependent kinase

1

12

High-throughput

0.407

High

95751

E5RFK5
Cyclin-C

1

6

High-throughput

0.407

High

1270841

SV2A
Synaptic vesicle glycoprotein 2A

1

2

High-throughput

0.407

High

1372191

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

1

High-throughput

0.407

High

1372208

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

3

High-throughput

0.407

High

1209037

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.279

Low

876103

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.249

Low

1010960

BAT1
b(0,+)-type amino acid transporter 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025