HitPredict

Interactor 1: CDN2D (Q60773)
Cyclin-dependent kinase 4 inhibitor D (p19-INK4d)
Gene: Cdkn2d

Interactor 2: CDK6 (Q64261)
Cyclin-dependent kinase 6 (EC 2.7.11.22) (CR2 protein kinase) (CRK2) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
Gene: CDK6

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	7739548
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Pkinase, Ank_2~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 166 Mm			1 326
+	Hs
		877470 CDN2D_HUMAN (1-166): 1.48e-53: 168: 86.75		CDK6_HUMAN (1-326): 4.61e-144: 410: 96.32
+	Hs
		790967 CDN2C_HUMAN (9-163): 6.87e-46: 149: 43.95		CDK6_HUMAN (1-326): 4.61e-144: 410: 96.32
+	Mm
		673235 CDN2D_MOUSE (1-166): 4.49e-55: 172: 100.00		CDK4_MOUSE (12-300): 5.54e-126: 364: 69.52
+	Hs
		515390 CDN2D_HUMAN (1-166): 1.48e-53: 168: 86.75		CDK4_HUMAN (9-300): 4.5e-126: 364: 70.51
+	Mm
		673234 CDN2C_MOUSE (9-163): 7.76e-47: 151: 42.68		CDK4_MOUSE (12-300): 5.54e-126: 364: 69.52
+	Hs
		625621 RAI14_HUMAN (1-100): 2.37e-23: 97.3: 23.08		CDK2_HUMAN (10-311): 4.32e-147: 417: 47.39
+	Hs
		515365 CDN2C_HUMAN (9-163): 6.87e-46: 149: 43.95		CDK4_HUMAN (9-300): 4.5e-126: 364: 70.51
+	Hs
		790922 CDN2B_HUMAN (12-126): 2.37e-25: 96.3: 52.59		CDK6_HUMAN (1-326): 4.61e-144: 410: 96.32
+	Hs
		790748 CDN2A_HUMAN (9-126): 2.69e-23: 91.3: 51.26		CDK6_HUMAN (1-326): 4.61e-144: 410: 96.32
+	Hs
		276137 PSD10_HUMAN (48-165): 2.8e-35: 124: 21.67		CDK4_HUMAN (9-300): 4.5e-126: 364: 70.51
+	Mm
		673242 PSD10_MOUSE (48-165): 2.77e-35: 124: 21.67		CDK4_MOUSE (12-300): 5.54e-126: 364: 69.52
+	Mm
		673230 CDN2B_MOUSE (12-126): 7.61e-26: 97.1: 52.59		CDK4_MOUSE (12-300): 5.54e-126: 364: 69.52
+	Hs
		515364 CDN2B_HUMAN (12-126): 2.37e-25: 96.3: 52.59		CDK4_HUMAN (9-300): 4.5e-126: 364: 70.51
+	Hs
		515363 CDN2A_HUMAN (9-126): 2.69e-23: 91.3: 51.26		CDK4_HUMAN (9-300): 4.5e-126: 364: 70.51
+	Mm
		673228 CDN2A_MOUSE (18-126): 3.04e-21: 86.7: 49.09		CDK4_MOUSE (12-300): 5.54e-126: 364: 69.52
+	Hs
		515476 ANR52_HUMAN (12-158): 1.87e-12: 65.9: 36.67		CDK4_HUMAN (9-300): 4.5e-126: 364: 70.51
+	Hs
		960304 MIB1_HUMAN (11-114): 7.85e-16: 75.6: 20.55		CDK5_HUMAN (11-303): 3.4e-116: 339: 45.64