HitPredict

Interactor 1: LCP2 (Q60787)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Interactor 2: NCK1 (Q99M51)
SH2/SH3 adapter protein Nck1 (Cytoplasmic protein Nck1) (NCK adapter protein 1) (Nck-1)
Gene: NCK1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15668918
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005911 - cell-cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 533 Mm			1 377
+	Hs
		557674 LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98		NCK1_HUMAN (1-377): 2.9e-97: 295: 98.94
+	Hs
		209043 LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98		NCK2_HUMAN (1-376): 7.37e-90: 277: 68.50
+	Hs
		557750 BLNK_HUMAN (52-520): 3.13e-36: 142: 22.80		NCK1_HUMAN (1-377): 2.9e-97: 295: 98.94
+	Hs
		209129 BLNK_HUMAN (52-520): 3.13e-36: 142: 22.80		NCK2_HUMAN (1-376): 7.37e-90: 277: 68.50
+	Mm
		763395 LCP2_MOUSE (1-533): 2.96e-77: 254: 100.00		FYN_MOUSE (6-130): 3.25e-22: 99.8: 21.26
+	Hs
		655347 LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98		P85A_HUMAN (241-376): 2.35e-22: 100: 19.57
+	Hs
		412165 LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98		FYN_HUMAN (6-130): 3.47e-22: 99.8: 21.26
+	Hs
		442821 LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98		HCK_HUMAN (2-130): 1.23e-21: 98.3: 22.31
+	Hs
		522951 LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98		SRC_HUMAN (6-130): 5.78e-19: 90.1: 21.26
+	Mm
		1141127 LCP2_MOUSE (1-533): 2.96e-77: 254: 100.00		GRB2_MOUSE (3-58): 7.7e-17: 80.6: 28.57
+	Hs
		924534 LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98		GRB2_HUMAN (3-58): 7.33e-17: 80.6: 28.57
+	Mm
		1141385 LCP2_MOUSE (1-533): 2.96e-77: 254: 100.00		GRAP_MOUSE (2-60): 2.91e-13: 70.1: 20.34
+	Hs
		655407 CLNK_HUMAN (302-528): 3.63e-43: 160: 31.22		P85A_HUMAN (241-376): 2.35e-22: 100: 19.57
+	Hs
		924670 CLNK_HUMAN (302-528): 3.63e-43: 160: 31.22		GRB2_HUMAN (3-58): 7.33e-17: 80.6: 28.57
+	Mm
		763411 CLNK_MOUSE (170-528): 4.86e-35: 138: 25.20		FYN_MOUSE (6-130): 3.25e-22: 99.8: 21.26
+	Mm
		536209 CLNK_MOUSE (170-528): 4.86e-35: 138: 25.20		FGR_MOUSE (6-183): 4.16e-22: 99.5: 14.84
+	Hs
		924727 BLNK_HUMAN (52-520): 3.13e-36: 142: 22.80		GRB2_HUMAN (3-58): 7.33e-17: 80.6: 28.57
+	Hs
		1261029 BLNK_HUMAN (52-520): 3.13e-36: 142: 22.80		SH3K1_HUMAN (6-79): 2.48e-14: 76.2: 19.74
+	Hs
		1261030 BLNK_HUMAN (52-520): 3.13e-36: 142: 22.80		VAV3_HUMAN (6-60): 5.05e-14: 75.6: 25.00
+	Mm
		1246941 BLNK_MOUSE (52-520): 1.69e-35: 140: 21.62		SH3K1_MOUSE (58-209): 2.45e-11: 67.4: 18.18